Progestins and oral contraceptive-induced lipoprotein changes: A prospective study

Lipson, Amy R.; Stoy, Diane B.; LaRosa, John C.; Muesing, Richard A.; Cleary, Patricia A.; Miller, Vincent; Gilbert, Peter R.; Stadel, Bruce V.

doi:10.1016/0010-7824(86)90065-x

Cited by 58 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with earlier studies of monophasic formulations, the change in total cholesterol seems to be lower in the present investigation (18)(19)(20)(21)(22). A study including the same two formulations as tested here, revealed similar increases in total cholesterol (9.5% and 4.9% after six months) and triglycerides (28% and 49%) and no significant difference between the formulations could be detected thus confirming the findings presented in this study (23).…”

Section: Discussioncontrasting

confidence: 91%

Effect of norethisterone and levonorgestrel in low‐dose multiphasic oral contraceptives on serum lipids

Wiik

Nordby²,

Paulsen³

1993

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

In a parallel, multicenter study in Norway and Finland involving a total of 196 healthy women (mean age 22.4 years, range 18-30), the effects on serum lipids and lipoproteins of two multiphasic oral contraceptives containing ethinyl estradiol (EE) but different progestins were examined. One formulation contained EE 35 micrograms and norethisterone (NET) 0.5 mg on days 1-7 and days 17-21 and elevated NET 1.0 mg during the midphase (days 8-16). The other formulation contained EE 30 micrograms on days 1-6 and days 12-21 and 40 micrograms on days 7-11 and phased levonorgestrel (LGN): 50 micrograms (days 1-6), 75 micrograms (days 7-11) and 125 micrograms (days 12-21). Both formulations induced significant elevation of total cholesterol (6.7 and 4.1%), Apo B (8.1 and 7.0%) as well as HDL (6.4 and 3.7%) for the EE/NET and EE/LGN formulation respectively. Mean serum levels of triglycerides were significantly elevated (58 and 47%). However, all mean serum lipid and lipoprotein values remained within the normal range, and no change in the calculated cholesterol ratio (HDL/total cholesterol) nor lipoprotein ratio (HDL/(HDL+LDL)) was observed. No significant difference between the formulations could be detected with respect to the effect on serum lipids and lipoproteins measured. The change in total cholesterol was smaller than reported in many studies of monophasic preparations. Taken together, these data suggest that only small alterations in lipid metabolism are elicited by these oral contraceptives.

show abstract

Section: Discussioncontrasting

confidence: 91%

Effect of norethisterone and levonorgestrel in low‐dose multiphasic oral contraceptives on serum lipids

Wiik

Nordby²,

Paulsen³

1993

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Low levels of HDL cholesterol apparently increase the risk of coronary heart disease in women and high levels decrease the risk (30)(31)(32). In general, EE raises and progestogens with androgenic properties (1 9-nortestosterone derivatives) lower HDL cholesterol levels (5,8,33). Elevations of both HDL and HDL-2 were seen in women on Marvelon@ and of HDL-2 with Mercilon@ at six months; the trend continued at 12 months, although not significantly.…”

Section: Discussionmentioning

confidence: 94%

Oral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone

Åkerlund

Almström

Högstedt

et al. 1994

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

The effect of two oral contraceptive (OC) pills, both containing 150 micrograms of desogestrel, but with 20 (Mercilon) or 30 micrograms (Marvelon/Desolett) of ethinyl estradiol on plasma levels of lipids, lipoproteins and sex hormone binding globulin (SHBG), total and free testosterone were compared in a double-blind, randomized, two-center study in a total of 60 women over one year. A significant rise with Marvelon but not with Mercilon was seen in total cholesterol, HDL cholesterol, HDL-3 and apolipoprotein B, whereas LDL cholesterol decreased with Mercilon only. These effects resulted in significant differences between the two groups in the magnitude of responses in all these parameters except HDL-3. HDL-2, apolipoprotein A-1 and total phospholipids were elevated with both pills after treatment and with no difference in the degree of response between groups. The HDL/LDL cholesterol ratio tended to increase in both groups and that of apolipoproteins A-1/B in the women on Mercilon. Total triglycerides increased in both groups, but more in the women on Marvelon. Total testosterone decreased, particularly in the Marvelon group, whereas the two pills caused a similar increase in SHBG and decrease in free testosterone. It is concluded that the direction of changes in plasma lipids and lipoproteins with both these pills may as a whole be interpreted as beneficial, and that the differences in effect on LDL cholesterol and apolipoprotein B may suggest a slightly advantageous effect of Mercilon in this aspect. However, the clinical significance of these changes is uncertain. The results indicate a lack of androgenicity of both pills.

show abstract

“…This effect may represent incomplete compensation for the increase in SV, or a direct effect of oestrogen on the resistance vessels; however, this theory remains controversial. whereas the opposite is true of progestins, and overall the combined OCP may increase LDL [18][19][20]. The female sex hormones also play a role in determining arterial compliance and some studies have reported fluctuations in AIx and arterial elasticity depending on the phase of the menstrual cycle [22][23][24], although the data are inconsistent [25,26].…”

Section: Discussionmentioning

confidence: 95%

Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: The ENIGMA Study

Hickson

Miles

McDonnell

et al. 2011

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

Progestins and oral contraceptive-induced lipoprotein changes: A prospective study

Cited by 58 publications

References 28 publications

Effect of norethisterone and levonorgestrel in low‐dose multiphasic oral contraceptives on serum lipids

Effect of norethisterone and levonorgestrel in low‐dose multiphasic oral contraceptives on serum lipids

Oral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone

Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: The ENIGMA Study

Contact Info

Product

Resources

About