Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis

Schatz, Frederick; Krikun, Graciela; Caze, Rebeca; Rahman, Mizanur; Lockwood, Charles J.

doi:10.1016/s0039-128x(03)00139-9

Cited by 43 publications

(34 citation statements)

References 105 publications

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“…BV density was significantly increased in biopsies with an atrophic or regressed endometrial histology, however, this correlated to fewer bleeding days when compared with other histological appearances, suggesting that vessel integrity and function, not density, is important in bleeding (Hickey et al 1999). Levels of vascular endothelial growth factor (VEGF) and tissue factor (TF) are also altered in the endometrium of women using Norplant (Runic et al 1997, 2000, Schatz et al 2003, and in particular TF was increased in the bleeding sites when compared with non-bleeding sites and may contribute to aberrant angiogenesis . Therefore, compromises in the vasculature and overall tissue integrity could play an important role in breakthrough bleeding (BTB).…”

Section: Introductionmentioning

confidence: 99%

The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women

Morison¹,

Zhang²,

Kaitu’u-Lino³

et al. 2007

Reproduction

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Breakthrough bleeding (BTB), a major side effect of long-acting progestogen (p)-only contraceptives in women, is the main reason for discontinuation of their use. To understand the mechanisms of BTB, a mouse model of endometrial breakdown and repair was adapted to evaluate the effects of long-term progestogens on the endometrium. Appropriately prepared mice received either an etonogestrel (ENG)-or levonorgestrel (LNG)-releasing subdermal implant. Forty eight hours after decidualization was induced in one uterine horn the majority of tissues were highly decidualized, designated 0 day (0d). Uteri were collected subsequently at 5-day intervals (to 45d) and both decidualized and non-decidualized horns were analysed for morphological changes, leukocyte infiltration and matrix metalloproteinase expression (MMP). In decidualized horns, large blood vessels (BV) developed and disturbance of tissue integrity was observed at 5d with substantial stromal breakdown by 10d, progressing until 25d when re-epithelialization was initiated. By 45d, the tissue was restored to its pre-decidualized state but with considerable tortuosity of the luminal epithelium. Tissue remodelling was not apparent in the non-decidualized horns before 35d, when hyperproliferation of the luminal epithelium resulted in tortuosity. Changes in morphology were similar with the two progestogens, but occurred more rapidly with LNG. Apart from macrophages, few leukocytes were present in non-decidualized horns but large infiltrates of neutrophils and uterine natural killer cells (uNK) were associated with tissue breakdown in decidualized tissue, many of these cells were MMP9-positive. MMP7 was primarily associated with tissue repair. Therefore, this model mimics some of the changes observed in endometria of women using p-only contraceptives and provides an opportunity for functional studies.

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Section: Introductionmentioning

confidence: 99%

The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women

Morison¹,

Zhang²,

Kaitu’u-Lino³

et al. 2007

Reproduction

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“…Progesteron has got both thrombotic and antithrombotic effects. It upregulates TF expression 58 and also induces the production of cytokines such as IL-4, which upregulates protein S, which inhibits coagulation. Progesteron dydrogesterone inhibits production of TNF-á (prothrombotic), but increases the levels of IL-4 (antithrombotic) and slight IL-6 (prothrombotic) 59 .…”

Section: Discussionmentioning

confidence: 99%

Role of Low Molecular Weight Heparin (LMWH) in the Treatment of Recurrent Missed Abortion

Begum

Ehsan²,

Ehsan³

et al. 2016

Bangladesh J Obstet Gynaecol

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Introduction:Recurrent pregnancy loss (RPL) is a common and frustrating obstetric problem affecting 0.5% -5% women in different population 1,2 . Approximately 15-20% of clinically recognized pregnancies are generally subjected to spontaneous abortion, mostly during first trimester 3 . Most of these abortions are early missed abortions. Missed abortion may be either embryonic (preclinical) or fetal miscarriage. Embryonic miscarriage is defined as an embryo with crown rump length of more than or equal to 5cm without cardiac activity, fetal miscarriage is defined as a fetus of 7-20 weeks size with negative cardiac activity 4 .Genetic factors including chromosomal disorders, single gene defects, and multifactorial factors account for 3.5-5% of the causes of recurrent missed abortion 5 . There is a big volume of literature describing that cytogenetic abnormality is detected in 31% of early missed abortion 6,7 . Other studies showed that foetal chromosomal abnormalities account for about 50% of first trimester and near 30% of second trimester pregnancy losses 8,9 . Studies revealed that maternal insertional translocation associated with recurrent missed abortion 10-15 .

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“…Таким образом, тканевая ги-поксия индуцирует экспрессию СЭФР в эндометрии [32]. СЭФР, известный также как «фактор сосудистой прони-цаемости» или васкулотропин, является одним из важ-нейших факторов регуляции ангиогенеза [33]. В эндоте-лии больших и малых сосудов обнаружены высокоаффин-ные рецепторы СЭФР, что подтверждает гипотезу о сосу-дистом эндотелии как основной мишени действия данно-го регуляторного пептида.…”

Section: таблица 1 уровень гормонов гипофиза и эстрадиола в перифериunclassified

Endothelial dysfunction markers in abnormal uterine bleeding in pubertal girls born with intrauterine growth retardation

Башмакова¹,

Melkozerova²,

Dankova³

et al. 2015

Ross. vestn. akush.-ginekol.

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Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis

Cited by 43 publications

References 105 publications

The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women

The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women

Role of Low Molecular Weight Heparin (LMWH) in the Treatment of Recurrent Missed Abortion

Endothelial dysfunction markers in abnormal uterine bleeding in pubertal girls born with intrauterine growth retardation

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