Progesterone vaginal gel vs. intramuscular progesterone in oil for luteal support in IVF: a large, prospective trial

Silverberg, Kaylen M.; Vaughn, T.C.; Hansard, L.J.; Burger, Natalie Z.; Minter, T.

doi:10.1016/j.fertnstert.2010.07.080

Cited by 2 publications

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“…A Cochrane meta-analysis concluded that ongoing pregnancy rates and live birth rates were higher with intramuscular progesterone compared with intravaginal progesterone. 11 However, more recent studies have resulted in conflicting conclusions [12][13][14][15] even considering 2 independent prospective trials conducted in the same institution. 13,14 There is currently no biological plausibility that either intravaginal or intramuscular routes of progesterone administration would be superior to one another.…”

Section: Introductionmentioning

confidence: 99%

Embryo Transfer Catheter Contamination With Intravaginal Progesterone Preparations in a Simulated Embryo Transfer Model Impairs Mouse Embryo Development: Are There Implications for Human Embryo Transfer Technique?

Ying

Mayer

et al. 2014

Reprod. Sci.

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Section: Introductionmentioning

confidence: 99%

Embryo Transfer Catheter Contamination With Intravaginal Progesterone Preparations in a Simulated Embryo Transfer Model Impairs Mouse Embryo Development: Are There Implications for Human Embryo Transfer Technique?

Ying

Mayer

et al. 2014

Reprod. Sci.

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Luteal phase support for assisted reproduction cycles

Linden¹,

Buckingham

Farquhar

et al. 2015

Cochrane Database of Systematic Reviews

251

149

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BackgroundProgesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic gonadotropin (hCG), which is produced by the corpus luteum. This occurs in the luteal phase of the menstrual cycle. In assisted reproduction techniques (ART) the progesterone or hCG levels, or both, are low and the natural process is insufficient, so the luteal phase is supported with either progesterone, hCG or gonadotropin releasing hormone (GnRH) agonists. Luteal phase support improves implantation rate and thus pregnancy rates but the ideal method is still unclear. This is an update of a Cochrane Review published in 2004 (Daya 2004). ObjectivesTo determine the relative effectiveness and safety of methods of luteal phase support in subfertile women undergoing assisted reproductive technology. Search methodsWe searched the Cochrane Menstrual Disorders and Subfertility Group (MDSG) Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, CINAHL, Database of Abstracts of Reviews of Effects (DARE), LILACS, conference abstracts on the ISI Web of Knowledge, OpenSigle for grey literature from Europe, and ongoing clinical trials registered online. The final search was in February 2011. Selection criteriaRandomised controlled trials of luteal phase support in ART investigating progesterone, hCG or GnRH agonist supplementation in in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycles. Quasi-randomised trials and trials using frozen transfers or donor oocyte cycles were excluded. Data collection and analysisWe extracted data per women and three review authors independently assessed risk of bias. We contacted the original authors when data were missing or the risk of bias was unclear. We entered all data in six different comparisons. We calculated the Peto odds ratio (Peto OR) for each comparison.

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Progesterone vaginal gel vs. intramuscular progesterone in oil for luteal support in IVF: a large, prospective trial

Cited by 2 publications

References 0 publications

Embryo Transfer Catheter Contamination With Intravaginal Progesterone Preparations in a Simulated Embryo Transfer Model Impairs Mouse Embryo Development: Are There Implications for Human Embryo Transfer Technique?

Embryo Transfer Catheter Contamination With Intravaginal Progesterone Preparations in a Simulated Embryo Transfer Model Impairs Mouse Embryo Development: Are There Implications for Human Embryo Transfer Technique?

Luteal phase support for assisted reproduction cycles

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