Progesterone in saliva.

Read, G F; Walker, R F; Riad-Fahmy, D

doi:10.1093/clinchem/32.10.1997a

Cited by 3 publications

(2 citation statements)

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“…The first RIAs for saliva applications were in-house developments for the analysis of steroid hormones, based either on in-house antibodies and tracers [66,67] or adaptations of commercial plasma RIAs for the saliva matrix [68][69][70]. RIAs meanwhile have been replaced by ELISA and other nonradioactive LBAs.…”

Section: Review Gröschlmentioning

confidence: 99%

Saliva: A Reliable Sample Matrix in Bioanalytics

Gröschl¹

2017

Bioanalysis

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Saliva is gaining increasing attention as a bioanalytical sample matrix. Mostly because of the easy and noninvasive collection, it is not only beneficial in endocrinological and behavioral science, but also in pediatrics. Saliva also has the advantage of being the only body fluid which can be collected even during physical exercise, for example, during sportive activities, and there are physiological characteristics that make it superior to serum/plasma or urine for specific scientific questions. This review provides an insight into the physiology of saliva formation, explaining how certain compounds enter this bodily fluid, and gives advice for collection, storage and analytical methods. Finally, it presents a number of reliable and proven applications for saliva analysis from scientific fields including endocrinology, sports medicine, forensics and immunology.

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Section: Review Gröschlmentioning

confidence: 99%

Saliva: A Reliable Sample Matrix in Bioanalytics

Gröschl¹

2017

Bioanalysis

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“…Preliminary studies of pulsatile progesterone patterns among the Lese of Zaire indicate that the suppression of luteal progesterone profiles that occurs during periods of weight loss may also be primarily a function of diminished activity of luteinized granulosa cells. Mid-Age Older (18)(19)(20)(21)(22) Years) (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) Years) (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) "Arithmetic mean (SE) or geometric mean (range of mean ? SE) for pulsatile progesterone characteristics calculated from serial samples collected at 15-minute intervals for 8 hours on days classified as either midluteal (ML, 5 to 10 days before menstrual onset) or late-Meal (LL, 2 to 4 days before menstrual onset).…”

Section: Pulsatile Progesterone Patternsmentioning

confidence: 99%

Measurements of Salivary Progesterone^a

Ellison

1993

Annals of the New York Academy of Sciences

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Human salivary steroids: Methodological considerations and applications in physical anthropology

Ellison

1988

Am. J. Phys. Anthropol.

136

111

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The measurement of steroid hormones in saliva presents a number of attractive opportunities to physical anthropologists and human biologists in areas including reproductive ecology, growth and development, behavioral physiology, and nutrition. Among the key advantages of salivary steroid assays, as opposed to plasma or urinary assays, are the noninvasive and nondisruptive nature of sample collection. Significant disadvantages exist as well, stemming from the increased level of assay sensitivity required and the need for carefully controlled sample collection. Methodological aspects of research design, sample collection and handling, and data analysis and interpretation in the use of salivary steroid assays are discussed in detail, with special attention given to commonly overlooked but potentially crucial considerations. A review of potential applications within physical anthropology includes the use of testosterone assays in studies of male reproductive function and aggressive behavior; the use of adrenal androgen assays in studies of human growth and maturation; the use of cortisol assays in studies of stress physiology and limbic system arousal; and the use of ovarian steroids in studies of female reproductive function.Steroids, as a class of biologically active molecules, are among the most potent and pervasive regulators of vertebrate physiology. They help to regulate basic energy metabolism, both catabolic mobilization of energy and anabolic accumulation of tissue; they serve as primary regulators of adolescent growth and reproductive maturation; they directly determine primary and secondary sex characters; they are crucial in the regulation of adult reproductive function; and they help regulate mineral and electrolyte balance. They are also implicated in the control of libido, aggression, maternal behavior, stress, learning, personality development, and psychopathology. Along with primary sites of production in the gonads and adrenals, and sites of peripheral conversion throughout the body, including skin, muscles, adipose tissue, kidneys, lungs, and liver, they appear also to be synthesized directly in the brain (Le Goascogne et al., 1987). As a group, steroids readily permeate the blood-brain barrier and thus provide one of the primary links between systemic physiology and the central nervous system. It is little wonder, then, that steroids have been the object of intense scientific interest, that several primary research journals restrict themselves exclusively to the chemistry and biology of steroids, or that research reports focusing on steroid physiology are found in journals from fields as diverse as nutrition, psychology, neuroscience, anthropology, social deviance, and child development.The great proliferation of research into steroid physiology dates from the development of reliable assay methods in the 1960s. Berson and Yallow's Nobel Prizewinning technique of radioimmunoassay allowed accurate measurement of circulating steroids in serum and urine. Later outgrowths of this technique all...

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Progesterone in saliva.

Cited by 3 publications

References 0 publications

Saliva: A Reliable Sample Matrix in Bioanalytics

Saliva: A Reliable Sample Matrix in Bioanalytics

Measurements of Salivary Progesterone^a

Human salivary steroids: Methodological considerations and applications in physical anthropology

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Progesterone in saliva.

Cited by 3 publications

References 0 publications

Saliva: A Reliable Sample Matrix in Bioanalytics

Saliva: A Reliable Sample Matrix in Bioanalytics

Measurements of Salivary Progesteronea

Human salivary steroids: Methodological considerations and applications in physical anthropology

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Measurements of Salivary Progesterone^a