Progesterone and abnormal uterine bleeding/menstrual disorders

Jewson, Michaela; Purohit, Prashant; Lumsden, Mary Ann

doi:10.1016/j.bpobgyn.2020.05.004

Cited by 39 publications

(36 citation statements)

References 34 publications

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“…Estrogen and progesterone play a key role in the establishment and continuation of pregnancy and the entire delivery process. P is the main biologically active progestin secreted by the ovary that binds to specific receptors in target tissues such as the endometrium and myometrium to maintain placental function [ 18 ]. It is also able to reduce the sensitivity of the uterine muscle to contraction to avoid abnormal uterine contractions during pregnancy [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion

Zhao¹,

Zhang

Lou³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Currently, medication abortion is widely used in clinical practice in China. The aim of this study was to investigate the effect of mifepristone with misoprostol treatment on the efficacy of patients with missed abortion (MA) and the safety of this drug regimen. 95 patients with MA treated in our hospital from February 2019 to April 2021 were collected as the subjects of this study, and the patients were divided into the control and the research groups according to different treatment modalities. Among them, 46 cases in the control group were treated by diethylstilbestrol combined with oxytocin and 49 cases in the research group were treated by mifepristone combined with misoprostol, and both groups underwent curettage after medication. The rates of complete abortion, time of embryo expulsion, time of operation, intraoperative bleeding, time of postoperative vaginal bleeding, amount of vaginal bleeding, rate of one-time curettage, the levels of serum estradiol (E2), progesterone (P), β-chorionic gonadotropin (β-hCG), and interleukin-18 (IL-18), and the incidence of adverse effects in the two groups were examined and compared. Alanine transaminase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and serum creatinine (Scr) were used as indicators to evaluate the safety of the drug. The results showed that the rates of complete abortion and one-time curettage were significantly higher in the study group than in the control group, while the time of embryo expulsion, operation time, intraoperative bleeding, postoperative vaginal bleeding time, and vaginal bleeding were significantly lower than in the control group. The serum E2, P, and β-hCG levels before curettage in both groups were significantly higher, and IL-18 levels were significantly lower than those at the time of admission, with E2, P, and β-hCG levels increasing more and IL-18 levels decreasing more in the research group. After drug treatment, no abnormal changes in liver and kidney functions were observed in both groups, and the incidence of adverse reactions was at a similar and lower level in both groups. This shows that mifepristone with misoprostol is a safer and more effective drug regimen for the treatment of MA, which can regulate the levels of serum sex hormones and inflammatory factors in the body, promote the shedding of placental tissue, and create conditions for improving the rate of curettage.

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Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion

Zhao¹,

Zhang

Lou³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, after understanding it, we can prevent the disease or carry out the symptomatic treatment. In the study of Jewson et al (25), progesterone was involved in the regulation of abnormal uterine bleeding, and the regulation of PRA and PRB receptors played A role, and their increase in the body would lead to endometrial hyperplasia, which may deteriorate into endometrial cancer. Hormones and sex issues are very important in married life (26,27).…”

Section: Comparison Of Vegf Expression Levels Between the Two Groups ...mentioning

confidence: 99%

Effect of Tiaojingzhixue Fang on the expression of sex hormone and endometrial tissue mRNA in perimenopausal patients with abnormal uterine bleeding

Guan¹,

Xue

Chu

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to investigate the effect of Tiaojingzhixue decoction on the expression of sex hormone and endometrial mRNA in perimenopausal patients with abnormal uterine bleeding. For this purpose, 84 patients with perimenopausal abnormal uterine bleeding who were treated in our hospital from January 2018 to January 2019 were divided into study group and control group, the control group was treated with mifepristone for six months, the clinical efficacy, time of symptom relief and disappearance, endometrial thickness, menstrual volume, adverse events, expression of sex hormone (ER), Progesterone receptor (PR), Lutropin (LH), Follicle-stimulating hormone (FSH), Estradiol (e2) and Vascular endothelial growth factor in endometrial tissue were compared between the two groups. The results showed that the clinical efficacy of the study group (97.61%) was significantly higher than the control group (80.95%) (P<0.05). There was no significant difference in endometrial thickness between the two groups before treatment, but after treatment for 1 month, 3 months and 6 months, endometrial thickness was thinner in the study group (P<0.05). There was no significant difference in menstrual volume between the two groups before treatment (P <0.05), but it was lower in the study group (P <0.05). The incidence of adverse reactions in the study group was 11.90% lower than in the control group (26.19%). The expression levels of ER, PR, LH, FSH and E2 were almost the same before treatment and there was no significant difference between the two groups (P>0.05), but they were lower in the study group after treatment (P<0.05). Before treatment, there was no significant difference in the level of VEGF between the two groups (P>0.05); after treatment, the level of Vegf in the study group was lower than the control group (P<0.05). After treatment, the level of Vegf in both groups was significantly higher than before treatment (P<0.05). In general, Tiaojingzhixue decoction can decrease the level of sex hormone and increase the expression of VEGF in patients with perimenopausal abnormal uterine bleeding.

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“…Тому у жінок з ановуляторними циклами відмічають тільки естрогенну стимуляцію ендометрія. Це призводить до постійної проліферації ендометрія, що проявляється у вигляді періодичних проривних кровотеч [1,14].…”

Section: етіопатогенезunclassified

Аномальна Маткова Кровотеча: Сучасний Аналіз Етіопатогенезу, Діагностики Та Лікування

Ситнiк¹

2021

UMJ

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Комунальне некомерційне підприємство «Міська клінічна лікарня № 1» Одеської міської ради, Одеса, Україна Анотація. У статті представлений сучасний аналіз етіопатогенезу аномальної маткової кровотечі, огляд наукових досліджень, що охоплюють симптоматику, методи діагностики та рекомендації щодо вибору тактики і лікування аномальної маткової кровотечі. Ключові слова: аномальна маткова кровотеча, гістероскопія, гістеректомія, фактори ризику, поліп ендометрія, аденоміоз, лейоміома, гіперплазія ендометрія, коагулопатія, овуляторна дисфункція.

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Progesterone and abnormal uterine bleeding/menstrual disorders

Cited by 39 publications

References 34 publications

Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion

Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion

Effect of Tiaojingzhixue Fang on the expression of sex hormone and endometrial tissue mRNA in perimenopausal patients with abnormal uterine bleeding

Аномальна Маткова Кровотеча: Сучасний Аналіз Етіопатогенезу, Діагностики Та Лікування

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