Progenitor‐cell‐enriched micrografts as a novel option for the management of androgenetic alopecia

Abstract

Regenerative medicine is a multidisciplinary field that combines engineering and life science principles to promote regeneration, potentially restoring the physiological condition in diseased tissues. Specifically, the developments of complex grafts enhance the intrinsic regenerative capacity of the host by altering its environment.Autologous micrografts obtained through Rigenera ® micrografting technology are able to promote derma and bone regeneration. Androgenetic alopecia (AGA) leads to

A Novel Autologous Micrografts Technology in Combination with Negative Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in Chronic/Refractory Ulcer

“…In vitro studies have shown that mechanically obtained micrografts are enriched with mesenchymal progenitor cells, growth factors, and extracellular matrix components [19,23]. The technology has been successfully applied in different clinical contexts: dentistry field [13], dermatology for androgenetic alopecia [9,24], traumatology for chondropathy [14], osteonecrosis [15], and cardiology field for cardiac ischemia [16]. Our present result demonstrated that micrografts helped a severe intractable wound to generate qualified granulation tissue.…”

Short-Term Efficacy of Autologous Cellular Micrografts in Male and Female Androgenetic Alopecia: A Retrospective Cohort Study

“…20 More recently, Ruiz et al studied the efficacy of ACM at 4, 6 and 12 months, among 100 AGA and showed significant increase in hair density (+33.3/cm 2 ) and percentage of thick hair (+5.6%) at 2 months. 21 …”

Evaluation of Bone Regeneration in Rat Calvaria Using Bone Autologous Micrografts and Xenografts: Histological and Histomorphometric Analysis

“…To date, the Rigenera® micrografting technology has demonstrated its efficacy in different clinical setting. It is widely used with dermal tissue sample for the treatment of complex wounds, such as dehiscences, chronic ulcers, and burns [ 17 , 18 , 19 , 20 , 21 , 22 ]; for dermatological applications, such as hypertrophic scars [ 23 ]; and for the management of androgenetic alopecia [ 24 , 25 ]; with cartilage samples for the management of chondropathy [ 26 , 27 ]; and with bone samples for the treatment of the osteonecrosis of the femoral head [ 28 ].…”