Profound Elevation in LDL Cholesterol Level Following a Ketogenic Diet: A Case Series

Crosier, Rebecca; McPherson, Ruth

doi:10.1016/j.cjco.2022.05.001

Cited by 7 publications

(12 citation statements)

References 8 publications

(14 reference statements)

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“…This follows previous work on the KD, insulin sensitivity and hepatic steatosis (Luukkonen et al, 2020;Tendler et al, 2007). However, the KD has also been shown to have negative effects on other aspects of cardiometabolic health (Crosier & McPherson, 2022). Jani et al (2022) demonstrated that rats fed a KD gained significant weight and fat pad mass, and while not examined in this study, previous work shows that the high saturated fat content of a KD results in increased low density lipoproteins (Crosier & McPherson, 2022).…”

Section: Clinical Implications Of the Kdsupporting

confidence: 82%

“…Jani et al. (2022) demonstrated that rats fed a KD gained significant weight and fat pad mass, and while not examined in this study, previous work shows that the high saturated fat content of a KD results in increased low density lipoproteins (Crosier & McPherson, 2022). Additionally, the specific KD used by Jani et al.…”

Section: Introductionmentioning

confidence: 63%

“…However, the KD has also been shown to have negative effects on other aspects of cardiometabolic health (Crosier & McPherson, 2022). Jani et al (2022) demonstrated that rats fed a KD gained significant weight and fat pad mass, and while not examined in this study, previous work shows that the high saturated fat content of a KD results in increased low density lipoproteins (Crosier & McPherson, 2022). Additionally, the specific KD used by Jani et al (2022) did not contain any carbohydrates, which may not be easily translated to clinical practice, and would be difficult to adhere to long term.…”

Section: Clinical Implications Of the Kdmentioning

confidence: 99%

“…This follows previous work on the KD, insulin sensitivity and hepatic steatosis (Luukkonen et al., 2020; Tendler et al., 2007). However, the KD has also been shown to have negative effects on other aspects of cardiometabolic health (Crosier & McPherson, 2022). Jani et al.…”

Section: Introductionmentioning

confidence: 99%

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The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

King

Notaro

2022

The Journal of Physiology

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Section: Clinical Implications Of the Kdsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 63%

Section: Clinical Implications Of the Kdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

King

Notaro

2022

The Journal of Physiology

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“…Intriguingly, a ketogenic diet can be the source of hypercholesterolemia. [3] Because little is known about the association between cholesterol and cardiac repolarization, we recorded action potentials on induced pluripotent stem cell-derived cardiomyocytes from a patient with congenital LQTS type 2 (p.A561P mutation in the KCNH2 gene) challenged with cholesterol. Impressively, cholesterol induced a 4-fold prolongation of action potential duration compared to baseline condition (P = 0.01, Fig.…”

mentioning

confidence: 99%

Long QT: Time to cut cholesterol?

Li¹,

Charpentier²,

Maguy³

2023

IJC Heart & Vasculature

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Ketogenic Diets Hold Therapeutic Potential Against Periodontal Inflammation

Karmakar,

Shivaprasad,

Arangaraju

et al. 2024

Curr Oral Health Rep

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Purpose of Review Periodontitis, one of the most prevalent diseases in the world, is caused by the accumulation of dysbiotic microbial biofilm on the teeth leading to chronic inflammation of the tissues surrounding the teeth. Type 2 diabetes mellitus (T2DM), obesity, chronic stress, and smoking are some of the risk factors for the disease. A high-carbohydrate diet also increases the risk of periodontal inflammation. Modifying diet and nutrition could serve as a preventive and therapeutic tool to target multiple risk factors simultaneously. Recent Findings Emerging evidence shows that the ketogenic diet induces hormetic stress and switches on various cell-protective anti-inflammatory and antioxidant mechanisms. The ketogenic diet also improves mitochondrial function, DNA repair, and autophagy. The diet can effectively treat periodontitis risk factors such as T2DM and obesity. By restricting carbohydrates, the diet improves glycaemic control in T2DM patients and can effectively produce fat loss and reduce BMI (body-mass index) in obese patients. Poor long-term compliance and high cost are the drawbacks of the diet and the potential of the diet to increase cardiovascular disease risk needs further investigation. Summary Taken together, ketogenic diets, through various mechanisms reduce inflammation, mitigate oxidative stress, improve metabolic health, and can be used as a therapeutic tool to treat periodontal inflammation. Since robust scientific evidence for the ketogenic diet is currently scarce, future research should study the diet's efficacy, effectiveness, and safety in managing periodontal inflammation.

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Profound Elevation in LDL Cholesterol Level Following a Ketogenic Diet: A Case Series

Cited by 7 publications

References 8 publications

The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

Long QT: Time to cut cholesterol?

Ketogenic Diets Hold Therapeutic Potential Against Periodontal Inflammation

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