The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

King, Alexa; Notaro, Nicole M

doi:10.1113/jp283784

Cited by 2 publications

(2 citation statements)

References 5 publications

(38 reference statements)

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“…The study found that a high-carbohydrate diet increased the expression of SREBP-1c and ChREBP, two transcription factors that promote the expression of adipogenic genes, including those for FAS, ACC and lipoprotein 1, which are essential for DNL. 4,18 DNL promoted steatosis and exacerbated oxidative stress by increasing lipid synthesis. Consistent with these findings, the present study showed that diets with different levels of carbohydrate affect hepatic lipid synthesis.…”

Section: Papermentioning

confidence: 97%

“…Studies have shown that a high carbohydrate diet increased the expression of sterol regulatory element binding protein 1c (SREBP-1c) and carbohydrate regulatory element binding protein (ChREBP), two transcription factors crucial for de novo lipogenesis (DNL). 18 This upregulation of triacylglycerol (TG) production from carbohydrates via DNL further promotes hepatic steatosis. In contrast, the ketogenic diet (KD) has recently grown in popularity as a high-fat diet that restricts carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

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Effects of short-term carbohydrate deprivation on glycolipid metabolism and hepatic lipid accumulation in mice

Gao,

Zhang,

Fan

et al. 2024

Food Funct.

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Section: Papermentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Effects of short-term carbohydrate deprivation on glycolipid metabolism and hepatic lipid accumulation in mice

Gao,

Zhang,

Fan

et al. 2024

Food Funct.

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Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue

Song,

Zheng,

Zhao

et al. 2023

Clin Proteom

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Background Metabolic associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, and it is also a high-risk factor for the development of other metabolic diseases. Shenling Baizhu powder (SLP) is a traditional Chinese herbal formula with good clinical efficacy against MAFLD. However, its molecular mechanism for the treatment of MAFLD is still not fully understood. This study used quantitative proteomics analysis to reveal the SLP action mechanism in the treatment of MAFLD by discovering the effect of SLP on protein expression in the liver tissue of MAFLD rats. Materials and methods Q-Orbitrap LC–MS/MS was used to identify the incoming blood compounds of SLP. The 18 SD male rats were randomly divided into 3 groups (n = 6): control group, HFD group and SLP group. The HFD group and SLP group were established as MAFLD rat models by feeding them a high-fat diet for 4 weeks. Afterwards, the SLP group was treated with SLP (10.89 g/kg/d) for 3 weeks. Biochemical parameters and liver pathological status were measured. Rat liver tissue was analyzed using DIA-based quantitative proteomics and the DEPs were validated by western blotting analysis. Results A total of 18 active compounds of SLP were identified and isolated to enter the bloodstream. Comparison of DEPs between control group vs. HFD group and HFD group vs. SLP group revealed that SLP restored the expression of 113 DEPs. SLP catalyzes oxidoreductase activity and binding activity on mitochondria and endoplasmic reticulum to promote lipid oxidative catabolism, maintain oxoacid metabolic homeostasis in vivo and mitigate oxidative stress-induced hepatocyte injury. And 52 signaling pathways including PPAR signaling, arachidonic acid metabolism and glycine, serine and threonine metabolism were enriched by KEGG. PPI topology analysis showed that Cyp4a2, Agxt2, Fabp1, Pck1, Acsm3, Aldh1a1, Got1 and Hmgcs2 were the core DEPs. The western blotting analysis verified that SLP was able to reverse the increase in Fabp1 and Hmgcs2 and the decrease in Pck1 induced by HFD, and the results were consistent proteomic data. Conclusion SLP ameliorates hepatic steatosis to exert therapeutic effects on MAFLD by inhibiting the expression of lipid synthesis genes and inhibiting lipid peroxidation in mitochondria. This study provides a new idea and basis for the study of SLP in the treatment of MAFLD and provides an experimental basis for the clinical application of SLP.

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The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

Abstract: support-information-section).

Cited by 2 publications

References 5 publications

Effects of short-term carbohydrate deprivation on glycolipid metabolism and hepatic lipid accumulation in mice

Effects of short-term carbohydrate deprivation on glycolipid metabolism and hepatic lipid accumulation in mice

Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue

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