Proflex, schizokinesis and the internal universe

Wh, Gantt

doi:10.1007/bf02699341

Cited by 3 publications

(2 citation statements)

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“…Early papers by Gantt defined several types of principles that govern conditioned behavior. Proflex is the formation of new neuronal pathways that are responsible for conditioned behavior [134]. Autokinesis is the development within the central nervous system of new behaviors that are different from the originally conditioned behavior and are not dependent on the external presentation of the original stimulus, thus these new behaviors arise from changes in the internal universe of the subject [135].…”

Section: Drug Conditioning: Proto-cognitive Aspects Of Physiological ...mentioning

confidence: 99%

“…The conditioning of paralyzed dogs, the removal of the organ that was stimulated in the initial conditioning, and the removal of the periphery nerves involved in the original stimulations all showed that the central nervous system was where the conditioned state was stored [134]. What is not known is how much of the internal state passes through the CNS.…”

Section: Drug Conditioning: Proto-cognitive Aspects Of Physiological ...mentioning

confidence: 99%

See 1 more Smart Citation

Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine

Mathews¹,

Chang²,

Devlin³

et al. 2022

Preprint

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Many aspects of health and disease are modeled using the abstraction of a “pathway” – a set of protein or other subcellular activities with specified functional linkages between them. This metaphor is a paradigmatic case of a deterministic, mechanistic framework that focuses biomedical intervention strategies on altering the members of this network or the up/down-regulation links between them – rewiring the molecular hardware. However, protein pathways and transcriptional networks share important properties with neural networks and related dynamical systems, which implies that they can exhibit interesting and unexpected capabilities such as trainability (memory) and information processing in a context-sensitive manner. Specifically, they may be amenable to manipulation via their history of stimuli (equivalent to experiences, in behavioral science). If true, this would enable a new class of biomedical interventions that targets aspects of the dynamic physiological “software” implemented by pathways and gene-regulatory networks. Here, we propose an expanded view of pathways from the perspective of basal cognition. We review clinical and laboratory data supporting the idea that a broader understanding of pathways (and how they process contextual information across scales) is a limiting factor for progress in many areas of physiology and neurobiology. We argue that a fuller understanding of the functionality and tractability of pathways must go beyond a focus on the mechanistic details of their structure, to encompass their physiological history and embedding within higher levels of organization in the organism, with numerous implications for data science addressing health and disease. Exploiting tools and concepts from behavioral and cognitive sciences is not just a philosophical stance on biochemical processes; at stake is a new roadmap for overcoming the limitations of today’s pharmacological strategies and for the inference of future therapeutic interventions impacting a wide range of disease states.

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Section: Drug Conditioning: Proto-cognitive Aspects Of Physiological ...mentioning

confidence: 99%

Section: Drug Conditioning: Proto-cognitive Aspects Of Physiological ...mentioning

confidence: 99%