The history of thought concerning the hypothalamus and its functions

Brooks, Chandler McC.

doi:10.1016/0361-9230(88)90075-5

Cited by 41 publications

(12 citation statements)

References 7 publications

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“…ASIC1a expression in the amygdala (Coryell et al 2007;Wemmie et al 2003), coupled to the present findings in the SIH and FPT models, may suggest that ASIC1a in the amygdala plays some role in modulating autonomic outflow to other brain areas implicated in the control of autonomic responses to stressful stimuli (Brooks 1988;DiMicco et al 2006;Dimicco and Zaretsky 2007). The therapeutic implications of the present findings suggest that ASIC inhibition may have some clinical relevance since autonomic responses are considered associated features of anxiety disorders (DSM-IV-TR 2000).…”

Section: Discussionmentioning

confidence: 50%

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models

et al. 2008

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Section: Discussionmentioning

confidence: 50%

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models

et al. 2008

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“…At the turn of the 20th century, there was limited knowledge of the function of this part of the brain surrounding the third ventricle based primarily on various pathological and clinical observations (180). Since then, extensive experimental evidence indicates that the hypothalamus contains the control systems that are critically involved in a wide range of homeostatic and rheostatic regulatory processes (29,185,235). Among these are the control of water balance, food ingestion and energy metabolism, body temperature and neuroendocrine secretion, and regulation of reproduction and various emotional states (76).…”

Section: Central Regions Involved In the Regulation Of Energy Homeostmentioning

confidence: 99%

Immortalized neurons for the study of hypothalamic function

Dalvi

Nazarians-Armavil

Tung

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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The hypothalamus is a vital part of the central nervous system: it harbors control systems implicated in regulation of a wide range of homeostatic processes, including energy balance and reproduction. Structurally, the hypothalamus is a complex neuroendocrine tissue composed of a multitude of unique neuronal cell types that express a number of neuromodulators, including hormones, classical neurotransmitters, and specific neuropeptides that play a critical role in mediating hypothalamic function. However, neuropeptide and receptor gene expression, second messenger activation, and electrophysiological and secretory properties of these hypothalamic neurons are not yet fully defined, primarily because the heterogeneity and complex neuronal architecture of the neuroendocrine hypothalamus make such studies challenging to perform in vivo. To circumvent this problem, our research group recently generated embryonic- and adult-derived hypothalamic neuronal cell models by utilizing the novel molecular techniques of ciliary neurotrophic factor-induced neurogenesis and SV40 T antigen transfer to primary hypothalamic neuronal cell cultures. Significant research with these cell lines has demonstrated their value as a potential tool for use in molecular genetic analysis of hypothalamic neuronal function. Insights gained from hypothalamic immortalized cells used in conjunction with in vivo models will enhance our understanding of hypothalamic functions such as neurogenesis, neuronal plasticity, glucose sensing, energy homeostasis, circadian rhythms, and reproduction. This review discusses the generation and use of hypothalamic cell models to study mechanisms underlying the function of individual hypothalamic neurons and to gain a more complete understanding of the overall physiology of the hypothalamus.

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“…There are multiple neurotransmitters and neuromodulators in hypothalamus (Brooks, 1988). Investigation of the extracellular levels of neurotransmitters and neuromodulators in hypothalamus provides valuable insights into the pathophysiological events that occur during I/R.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis

Zhang

et al. 2010

Journal of Neuroscience Methods

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The history of thought concerning the hypothalamus and its functions

Cited by 41 publications

References 7 publications

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models

Immortalized neurons for the study of hypothalamic function

Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis

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