“…NGX6b can bind to the cell membrane via an intracellular region with ezrin and inhibit the cell proliferation, cell invasion, and metastasis of nasopharyngeal carcinoma through the EGF receptor signaling pathway (12,13). NGX6b can also inhibit the invasion of colon cancer cells by inhibiting the Wnt/-catenin signaling pathway (4,5,14). The isoform NGX6a was recently found to be expressed in various organs, mainly in epithelial cells and neuronal cells in the brain, nasopharynx, and lung, whereas NGX6b is expressed in the brain, heart, kidney, nasopharynx, and lung, and the expression levels of NGX6a are much higher than are those of NGX6b (3).…”