Profiling and characterization of microRNAs responding to sodium butyrate treatment in A549 cells

Xiao, Xiaoqiang; Cao, Yihan; Chen, Haoyu

doi:10.1002/jcb.26547

Cited by 27 publications

(19 citation statements)

References 28 publications

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“…Several in vivo and in vitro studies have reported that SCFAs, mainly butyrate, exert anticancer effects, such as suppressing cell growth, migration and invasion, on colon cancer (3,4). Recently, sodium butyrate treatment was shown to upregulate miR-3935 expression, which prohibited the proliferation and migration of A549 cells (5). However, despite studies on the roles of SCFAs in the colon, the anticancer effects of SCFAs, especially propionate, on lung cancer are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

et al. 2019

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Short-chain fatty acids (SCFAs; butyrate, propionate and acetate) are metabolites derived from the gut microbiota via dietary fiber fermentation. In colon cancer, treatment with SCFAs, mainly butyrate and propionate, suppresses cell proliferation, migration and invasion. Furthermore, although sodium butyrate is known to induce cell apoptosis in lung cancer, the anticancer effects of sodium propionate (SP) on lung cancer are not well understood. In the present study, SP treatment induced cell cycle arrest, especially in the G2/M phase, and cell apoptosis in the H1299 and H1703 lung cancer cell lines. As determined by reverse transcription-quantitative PCR and western blotting, Survivin and p21 expression levels were significantly affected by SP treatment, suggesting that SP treatment suppressed cell proliferation in these lung cancer cell lines. Thus, it was proposed that the SP-mediated regulation of Survivin and p21 in lung cancer may be applicable to lung cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

et al. 2019

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“…Interestingly, circulating levels of miR-29a have also been proposed as a biomarker for cancer progression in colorectal cancer [61]. Unfortunately little is known about miR-3935, although it has been found to be down-regulated in some neurodegenerative disorders [62], and up-regulated expression reduced proliferation and migration in A549 cells [23] .…”

Section: Discussionmentioning

confidence: 99%

An <i>In Silico</i> Study: Can the Modulation of miRNA Expression through a Diet that Promotes the Production of Butyrate and Consumption of Genistein and Quercetin, Impact Cancer?

Jun¹,

Bishop²

2018

JFNR

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Diet plays a major role in regulating cancer. Bioactives such as polyphenols and isoflavones found naturally in our food are increasingly being recognised as regulators of interest. These compounds can regulate cancer pathways through microRNAs which are critical in modulating expression of various genes. We carried out a literature review wherein we assessed the impact of three dietary compounds, namely butyrate, genistein and quercetin, on miRNA expression followed by an in silico study utilising DIANA-miRPathv3 software. Our literature search found that miR-34a, miR-200a-3p and miR-200b-3p were modulated by all three compounds while miR-221, miR-222, miR-29a, miR-3935 and miR-574-3p were modulated by both genistein and butyrate and let-7b, miR-194, miR-96-5p and miR-424 were modulated by butyrate and quercetin. The in silico analysis identified key pathways of interest such as "bladder cancer" which had significant interactions with the miRNAs modulated by the dietary compounds.

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“…Thus butyrate can exert an anti-cancer effect through increasing p21 via decreasing miR106B. Xiao et al (2018) studied miRs altered by butyrate in non-small cell lung cancer cell line A549 and found 33 miRs upregulated and 22 miRs down-regulated [164]. Among them, miR-3935 and miR-574-3p were most upregulated.…”

Section: Effects Of Butyrate On Micrornasmentioning

confidence: 99%

Effects of Intestinal Microbial–Elaborated Butyrate on Oncogenic Signaling Pathways

2019

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The intestinal microbiota is well known to have multiple benefits on human health, including cancer prevention and treatment. The effects are partially mediated by microbiota-produced short chain fatty acids (SCFAs) such as butyrate, propionate and acetate. The anti-cancer effect of butyrate has been demonstrated in cancer cell cultures and animal models of cancer. Butyrate, as a signaling molecule, has effects on multiple signaling pathways. The most studied effect is its inhibition on histone deacetylase (HDAC), which leads to alterations of several important oncogenic signaling pathways such as JAK2/STAT3, VEGF. Butyrate can interfere with both mitochondrial apoptotic and extrinsic apoptotic pathways. In addition, butyrate also reduces gut inflammation by promoting T-regulatory cell differentiation with decreased activities of the NF-κB and STAT3 pathways. Through PKC and Wnt pathways, butyrate increases cancer cell differentiation. Furthermore, butyrate regulates oncogenic signaling molecules through microRNAs and methylation. Therefore, butyrate has the potential to be incorporated into cancer prevention and treatment regimens. In this review we summarize recent progress in butyrate research and discuss the future development of butyrate as an anti-cancer agent with emphasis on its effects on oncogenic signaling pathways. The low bioavailability of butyrate is a problem, which precludes clinical application. The disadvantage of butyrate for medicinal applications may be overcome by several approaches including nano-delivery, analogue development and combination use with other anti-cancer agents or phytochemicals.

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Profiling and characterization of microRNAs responding to sodium butyrate treatment in A549 cells

Cited by 27 publications

References 28 publications

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

An <i>In Silico</i> Study: Can the Modulation of miRNA Expression through a Diet that Promotes the Production of Butyrate and Consumption of Genistein and Quercetin, Impact Cancer?

Effects of Intestinal Microbial–Elaborated Butyrate on Oncogenic Signaling Pathways

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