Profiles of neonicotinoid insecticides and characteristic metabolites in paired urine and blood samples: Partitioning between urine and blood and implications for human exposure

Xu, Miaomiao; Zhang, Zhanpeng; Li, Zhiyong; Kan, Shunyan; Liu, Zhaoxiang; Wang, Desheng; Liu, Qihui; Zhang, Hua

doi:10.1016/j.scitotenv.2021.145582

Cited by 50 publications

(42 citation statements)

References 69 publications

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“…Our results indicated that the population collected for this study had a high concentration of exposure to DIN, CLO, ACE, and THI. A similar pattern was also found in previous study, which suggested that high level of exposure to CLO, ACE, and DIN was observed in Chinese population (Xu et al 2021). Among the m-NEOs, Of-IMI (1.28 ng/mL) had the highest median concentration in blood samples, followed by ACE-dm (0.79 ng/mL) and UF (0.73 ng/mL; Table 1).…”

Section: Occurrences Of Neos and Their Metabolites In The Bloodsupporting

confidence: 90%

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Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Zhang¹,

Zhang²,

Zeng³

et al. 2021

Preprint

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Neonicotinoid insecticides (NEOs) are commonly applied for pest control in China and around the world. They have potential toxicity to bees, birds, mammals, and even human being. However, limited studies have explored the associations between NEOs exposure and disease. In the present study, we detected six parent NEOs (p-NEOs), including acetamiprid, thiacloprid, dinotefuran, clothianidin, imidacloprid, and thiamethoxam, and five characteristic metabolites (m-NEOs), including 5-hydroxy-imidacloprid (5-OH-IMI), olefin-imidacloprid (Of-IMI), N-desmethyl-acetamiprid, 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine and 1-methyl-3-(tetrahydro-3-furyl methyl) urea, in blood samples collected from healthy (n = 100) and liver cancer (n = 274) populations in South China. NEOs were frequently detected (61–94%) in blood samples, with median concentrations ranging from 0.19 ng/mL to 1.28 ng/mL and 0.20 ng/mL to 2.03 ng/mL for healthy and liver cancer populations, respectively. Of-IMI was the most abundant NEOs in healthy and liver cancer populations, accounting for 23.4% and 20.7%, respectively. Significant positive correlations among most m-NEOs concentrations were found, and associations between m-NEOs and their corresponding p-NEOs were positively correlated. These findings indicated that the sources of m-NEOs were both endogenous and exogeneous. Females had higher median concentrations of NEOs and their metabolites than males. Moreover, associations between the concentrations of p-NEOs and m-NEOs and liver cancer were found (odds ratio = 2.33–9.02, 95% confidence interval = 0.31–22.7, p < 0.05), indicating that human exposure to NEOs and their metabolites might increase the odds of liver cancer prevalence. This study is the first work to document 5-OH-IMI and DN in blood samples collected from South China.

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Section: Occurrences Of Neos and Their Metabolites In The Bloodsupporting

confidence: 90%

“…Sample extraction protocol was based on our previous study (Xu et al 2021). In brief, the internal standard solution (5 ng) was added into 0.5 mL of serum sample.…”

Section: Analysis Of Neos and Their Metabolitesmentioning

confidence: 99%

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Zhang¹,

Zhang²,

Zeng³

et al. 2021

Preprint

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“…Previous NNI biomonitoring studies have consistently reported gender‐related differences in NNI exposures within various populations across the world (Ospina et al 2019; Li and Kannan 2020; Song et al 2020; Wang et al 2020; Xu et al 2021). To validate the concordance between the present study and previous findings, we estimated the daily intakes of NNIs among male and female groups within the present study population (Table 6).…”

Section: Resultsmentioning

confidence: 99%

“…Most previous human studies have consistently observed higher NNI exposure trends in females than males. For instance, Xu et al (2021) and Wang et al (2020) recorded higher daily intakes of NNIs in females than males within a Chinese population. According to Xu et al (2021), the gender‐related differences observed in urinary NNI exposures in human subjects could be the result of sex‐specific differences in NNI metabolism.…”

Section: Resultsmentioning

confidence: 99%

“…For instance, Xu et al (2021) and Wang et al (2020) recorded higher daily intakes of NNIs in females than males within a Chinese population. According to Xu et al (2021), the gender‐related differences observed in urinary NNI exposures in human subjects could be the result of sex‐specific differences in NNI metabolism. However, current data on sex‐related metabolism NNIs are limited.…”

Section: Resultsmentioning

confidence: 99%

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Human Exposures to Neonicotinoids in Kumasi, Ghana

Nimako

Ikenaka

Akoto

et al. 2021

Enviro Toxic and Chemistry

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Neonicotinoid insecticides (NNIs) are now popular in many agricultural systems across Africa; however, the extent of human exposures to NNIs in African countries is scarcely reported. The present study evaluates neonicotinoid exposures in the consumer population of Kumasi, a cosmopolitan city in Ghana. A total of 75 human urine samples were collected from healthy volunteers (nonfarmers, aged 13-80 yr) and analyzed with a liquid chromatography electrospray ionization tandem mass spectrometry system. Seven NNIs and 3 NNI metabolites were detected in the following pattern (frequency, median concentration, maximum concentration): N-dm-acetamiprid (94.7%, 0.41 µg/L, 8.79 µg/L) > imidacloprid (70.7%, 0.15 µg/L, 211.62 µg/L) > N-(6-chloro-3-pyridylmethyl)-N-ethyl-N′-methylformamidine (62.2%, 0.43 µg/L, 53.85 µg/L) > 2-[N-(6-chloro-3pyridylmethyl)-N-ethylamino]-2-(methylimino)acetic acid (56.8%, 0.10 µg/L, 3.53 µg/L) > clothianidin (40%, >limit of quantification [LOQ], 0.45 µg/L) > nitenpyram (18.7%, >LOQ, 0.14 µg/L) ≈ thiamethoxam (18.7%, >LOQ, 0.21 µg/L) > dinotefuran (12.0%, >LOQ, 1.01 µg/L) > acetamiprid (2.7%, >LOQ, 0.08 µg/L) ≈ thiacloprid (2.7%, >LOQ, 0.14 µg/L). Approximately 92% of the subjects were found to be exposed to multiple neonicotinoids simultaneously. The mean, median, and maximum imidacloprid equivalent of the relative potency factor of NNIs were found to be 1.6, 0.5, and 22.52, respectively. The median estimated daily intakes of acetamiprid, imidacloprid, and nitenpyram were 0.47, 1.27, and 0.02 µg/kg/d for females and 0.91, 0.66, and 0.08 µg/kg/d for males, respectively. The maximum daily intakes of all the NNIs were <1% of their chronic reference doses (cRfDs), except for imidacloprid and thiacloprid which recorded maximum daily intakes corresponding to 17.97 and 8.28% of cRfDs, respectively. To the best of our knowledge, the present study is the first biomonitoring report on neonicotinoid insecticides in Africa.

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Determination of organophosphate flame retardant tris(2‐chloroethyl)phosphine based on the luminol–H₂O₂ chemiluminescence system

et al. 2021

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Organophosphorus flame retardants (OPFRs) are new types of environmental pollutants, therefore the rapid and sensitive detection of OPFRs is a very important objective. A new experimental phenomenon was found in which tris(2-chloroethyl) phosphine (TCEP), a type of OPFR, could effectively enhance the signal of the luminol-H 2 O 2 chemiluminescence (CL) system. Combined with the controllability of flow injection analysis, a rapid, stable, and sensitive CL method was established.The CL intensity responded linearly to the concentration of TCEP in the range 0.5-100 μg/L (R 2 = 0.999) with a low detection limit of 33 ng/L. Relative standard deviation (RSD) was 2.2% (n = 7, c = 100 μg/L). Water samples were labelled and recycled with RSDs of 1.1-5.7% and recoveries of 88.7-116.1%. Based on these results, this study established a new CL detection method for the environmental pollutant TCEP.

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Profiles of neonicotinoid insecticides and characteristic metabolites in paired urine and blood samples: Partitioning between urine and blood and implications for human exposure

Cited by 50 publications

References 69 publications

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Human Exposures to Neonicotinoids in Kumasi, Ghana

Determination of organophosphate flame retardant tris(2‐chloroethyl)phosphine based on the luminol–H₂O₂ chemiluminescence system

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Profiles of neonicotinoid insecticides and characteristic metabolites in paired urine and blood samples: Partitioning between urine and blood and implications for human exposure

Cited by 50 publications

References 69 publications

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Human Exposures to Neonicotinoids in Kumasi, Ghana

Determination of organophosphate flame retardant tris(2‐chloroethyl)phosphine based on the luminol–H2O2 chemiluminescence system

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Product

Resources

About

Determination of organophosphate flame retardant tris(2‐chloroethyl)phosphine based on the luminol–H₂O₂ chemiluminescence system