Profile protein autism analysis based bioinformatics as public dissemination materials in Malang about the potensial causes autism

Abstract

ABSTRAKKehidupan saat ini menawarkan berbagai kemudahan. Namun, seiring dengan hal tersebut ada banyak permasalahan yang memicu stress. Selain itu, terdapat banyak unsur kimia dan logam berat yang jika saling berinteraksi dapat menimbulkan berbagai macam penyakit mulai dari flu hingga kanker, termasuk autis. Penelitian ini bertujuan untuk menganalisis potensi profil protein dalam darah yang menyebabkan autis berdasarkan bioinformatik. Kemudian, disosialisasikan kepada masyarakat khususnya orang tua anak autis di Kota Malang sehingga dapat memberikan wawasan tentang autis. Penelitian ini juga dapat dikembangkan sebagai dasar penelitian laboratorium. Jenis penelitian ini adalah deskriptif kualitatif, menggunakan tiga database yaitu National Center for Biotechnology Information (NCBI), Uniprot, dan Protein Data Bank (PDB) serta menggunakan software Pymol. Hasil penelitian ini menunjukkan bahwa: 1) Protein dalam darah yang berpotensi menyebabkan autis berdasarkan artikel yaitu mTOR, Glutathione S Transferase P, Chemokine Monocyte Chemotactic Protein-1 (MCP-1), Interferon-∂-Inducible Protein-16 (IFI-16), dan serotonin; 2) Protein-protein tersebut setelah dianalisis dengan menggunakan tiga database (NCBI, Uniprot, dan PDB) menunjukkan bahwa protein Glutathione S Transferase P lebih berpotensi terhadap autis. Hal ini karena protein tersebut berfungsi untuk mencegah neurodegeneration; 3) Penelitian tentang penyebab autis sangat dibutuhkan oleh orang tua anak autis (masyarakat), sehingga dapat diminimalisir akses masuknya pemicu tersebut. ABSTRACTLife currently offers various facilities. However, along with this there are many issues which trigger stress. In addition, there are many chemical elements and heavy metals which, when interacting can cause a variety of illnesses ranging from colds to cancer, including autism. This study aims to analyze the potential of the protein profile in the blood that cause autism based bioinformatics. Then, to inform the public, especially parents of autistic in Malang so as to provide insight into autism. This research could also be developed as the basis of laboratory research. The research is a qualitative descriptive, using three databases, namely the National Center for Biotechnology Information (NCBI), Uniprot, and the Protein Data Bank (PDB) and using software PyMOL. The results of this study show that: 1) protein in the blood that could potentially cause autism based on articles that mTOR, glutathione S transferase P, Chemokines monocyte chemotactic protein-1 (MCP-1), Interferon-∂-Inducible , and serotonin; 2) The following proteins were analyzed using three databases (NCBI, Uniprot, and GDP) showed that the protein glutathione S transferase P is more potent against autism. This is because the protein's function is to prevent neurodegeneration; 3) Research on the causes of autism is needed by parents of autistic children (society), so as to minimize access to the entry of such triggers.

Combination of Tolo and Soy Bean Ice Cream as an Alternatif Snack for Autistic Children

“…Autistic children have imperfect protein digestion, often there is an enzyme disorder that functions to break down peptide bonds so that protein digestion is disrupted. Whereas protein in autistic children is very useful for the body's defense against mercury, toxic metals and toxic chemicals [38]. In addition, in autistic children, protein affects zinc absorption which can affect hair health of autistic children, protein greatly affects the nutritional status of autistic children [39].…”