Profile of Typhoid Fever in Children from a Tertiary Care Hospital in Chennai-South India

Ganesh, Ramaswamy; Janakiraman, Lalitha; Vasanthi, Thiruvengadam; Sathiyasekeran, Malathi

doi:10.1007/s12098-010-0196-9

Cited by 39 publications

(64 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,7,10 Leucocytosis (11.4%) and leucopenia (5.9%) in our study is comparable to other studies. However, leucopenia is less as compared to IAP report (20-25%).…”

Section: Discussionsupporting

confidence: 91%

“…Other large series include R Ganesh et al, J Gavhane et al and Walia et al 7,10,11 In our study, we noted that of the total patients, 11.3% were less than 2 years, 24.5% were between 2 to 5 years, 44.8% were between 5 to 10 years and 18.9% were between 10 to 14 years. R Ganesh et al in their study of enteric fever at Chennai noted 17.8% patients less than 2 years, 32% between 2 to 5 years, 33.5% between 5 to 10 years and 15.8% more than 10 years.…”

Section: Discussionsupporting

confidence: 60%

“…R Ganesh et al in their study of enteric fever at Chennai noted 17.8% patients less than 2 years, 32% between 2 to 5 years, 33.5% between 5 to 10 years and 15.8% more than 10 years. 7 The comparison shows that there is maximum incidence of enteric fever between 5 to 10 years of age. In addition, in the preschool age (below 5 years), the incidence is quite high in both the studies.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies show absolute eosinopenia in the range of 0-80%. 4,7,10 This can be attributed to baseline high eosinophil counts seen in many children in eastern Ahmedabad due to parasitic infestations or pollutants from nearby chemical industries. Thrombocytopenia in our study is less (8.6%) as compared to IAP report (10-15%) and Gavhane et al (30%).…”

Section: Discussionmentioning

confidence: 99%

“…5 Also according to various studies, there is significant increase in Nalidixic acid resistant salmonella typhi (NARST). 6,7 Cephalosporins such as ceftriaxone and cefixime are recommended as first line drugs but studies are required to study defervescence and relapse rates. Azithromycin which is recommended as a second line drug also, needs to be studied, as there is limited experience of its clinical use in enteric fever.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Current perspectives of enteric fever: a hospital based study of 185 culture positive cases from Ahmedabad, India

Jeeyani

Mod

Tolani³

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Enteric fever is endemic in Ahmedabad and its diagnosis and treatment is fraught with problems. The last two decades have seen a change in clinical pattern of enteric fever with emergence of multi drug resistant strains. Hence, the study was carried out with the aims to study the clinical profile, hematological features, sensitivity pattern, response to antimicrobials and outcome of culture proven enteric fever.Methods: This was a retrospective study carried out at a tertiary care teaching hospital at Ahmedabad, India from January 2014 to December 2016.Results: Out of the 185 study patients, 35.8 % were less than 5 years of age. Of the total 185 isolates, 160 (86.4%) were Salmonella typhi while 25 (13.6%) were Salmonella paratyphi A. Following sensitivity patterns were recorded: cotrimoxazole (93%), chloramphenicol (93%), ampicillin (96.2%), nalidixic acid (98.4%), cephalosporins (100%) and azithromycin (70.8%). Leukocytosis was seen in significant number of patients less than 5 years of age as compared to more than 5 years. 91.9% patients were treated by ceftriaxone as a monotherapy with defervescence time of 3.8 days and no mortality.Conclusions: Effective vaccination strategy targeting children less than 5 years can decrease the burden of this disease. Presence of fever without focus and leukocytosis in less than 5 years suggests possibility of enteric fever. Salmonella have once again become sensitive to first line antibiotics like ampicillin, cotrimoxazole and chloramphenicol. There is a good rate of sensitivity to nalidixic acid but high rate of resistance against azithromycin in this part of the country. Ceftriaxone as a monotherapy is quite effective in the treatment.

show abstract

“…4,7,10 Leucocytosis (11.4%) and leucopenia (5.9%) in our study is comparable to other studies. However, leucopenia is less as compared to IAP report (20-25%).…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Current perspectives of enteric fever: a hospital based study of 185 culture positive cases from Ahmedabad, India

Jeeyani

Mod

Tolani³

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy

et al. 2023

View full text Add to dashboard Cite

Food allergy is recognized as a global medical problem with increasing prevalence in recent years. Currently, the treatment of food allergy mainly involves avoidance of allergens and allergen-specific immunotherapy. Barring the spontaneous resolution of food allergy during the growth process, this disease is difficult to treat fundamentally. In recent years, the use of functional food ingredients derived from natural products has been attracting attention for their prophylactic use in food allergy. Theaflavins, i.e. black tea polyphenols, are potent antioxidants that have inhibitory effects on a variety of diseases. However, little is known about the preventive effect of theaflavins on food allergy. In this study, we designed a mouse model of food allergy and examined the effect of theaflavins using the severity of diarrhea, a symptom of food allergy, as an indicator. The administration of a black tea extract rich in theaflavins or theaflavin 1 (subgroup of theaflavins) to mice reduced the severity of diarrhea when compared with a normal diet. A reduction in malondialdehyde levels, a key marker of lipid peroxidation, was also observed. Overall, these data suggest that theaflavins may potentially inhibit food allergy by alleviating oxidative stress in the colon and can be a potential food material for prevention of food allergy.

show abstract

Pseudotumour Cerebri with Multiple Cranial Nerve Palsies in Enteric Fever

Bhatt

Dewan

et al. 2013

Indian J Pediatr

View full text Add to dashboard Cite

Profile of Typhoid Fever in Children from a Tertiary Care Hospital in Chennai-South India

Cited by 39 publications

References 7 publications

Current perspectives of enteric fever: a hospital based study of 185 culture positive cases from Ahmedabad, India

Current perspectives of enteric fever: a hospital based study of 185 culture positive cases from Ahmedabad, India

Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy

Pseudotumour Cerebri with Multiple Cranial Nerve Palsies in Enteric Fever

Contact Info

Product

Resources

About