Profile of Serum IL-1β and IL-10 Shortly after Ovariectomy and Estradiol Replacement in Rats

Percegoni, Nathércia; Ferreira, Andrea Cláudia Freitas; Rodrigues, Carlos; Rosenthal, Doris; Branco, Maria dos Remédios Freitas Carvalho; Rumjanek, Vivian M.; Carvalho, Denise Pires de

doi:10.1055/s-0028-1087173

Cited by 21 publications

(12 citation statements)

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“…In ovariectomized rats, circulating levels of IL-6, TNF-α, and IL-1β were found to be increased significantly 39–41. However, to our knowledge, there have been few reports on changes of cytokines in surgically menopausal women.…”

Section: Discussionmentioning

confidence: 91%

Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

Tani¹,

Matsui²,

Kato³

et al. 2013

JIR

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PurposeThe aim of the study reported here was to determine the effect of surgical menopause by bilateral salpingo-oophorectomy (BSO) on circulating levels of cytokines and chemokines related to the pathogenesis of atherosclerosis.Patients and methodsA total of 110 women were recruited for this study from the outpatient clinic of our facility. We divided the women into three groups: 1) women with a regular menstrual cycle, 2) women in whom less than 5 years had passed since their BSO, and 3) women in whom 5 years or more had passed since their BSO. Concentrations of nine cytokines and chemokines in serum were measured.ResultsThe serum monocyte chemoattractant protein-1 (MCP-1) level in women in whom less than 5 years had passed since their BSO was significantly higher than in women with a regular menstrual cycle (P<0.05). There were significant differences in serum interleukin (IL)-7 among the three groups (P=0.035). MCP-1 showed a significant positive correlation (r=0.320, P=0.008) with follicle-stimulating hormone in women with a regular menstrual cycle and in women in whom less than 5 years had passed since their BSO.ConclusionA hypoestrogenic state due to BSO induced changes in MCP-1 and IL-7 levels. MCP-1 level showed a significant increase in the early period after BSO, while IL-7 level showed a significant decrease in the late period after BSO.

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Section: Discussionmentioning

confidence: 91%

Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

Tani¹,

Matsui²,

Kato³

et al. 2013

JIR

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“…Previous studies demonstrated that OVX rats have an increase in body mass that could be a consequence of a hyperphagic state (32,33), a decrease in energy expenditure (EE) (50), or both. Thus these animals show an increase in adipose tissue (43), fat content in the liver (43,44), heart and skeletal muscle (28), dyslipidemia (28,53), insulin resistance (46,51), and changes in the serum cytokine profile (37), which are characteristics of a metabolic syndrome. These metabolic disturbances that lead to changes in body composition and insulin resistance are also detected in postmenopausal women (29, 31, 59a).…”

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confidence: 99%

Role of estrogen on skeletal muscle mitochondrial function in ovariectomized rats: a time course study in different fiber types

Cavalcanti-de-Albuquerque

Salvador

Martins

et al. 2014

Journal of Applied Physiology

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Postmenopausal women are prone to develop obesity and insulin resistance, which might be related to skeletal muscle mitochondrial dysfunction. In a rat model of ovariectomy (OVX), skeletal muscle mitochondrial function was examined at short- and long-term periods after castration. Mitochondrial parameters in the soleus and white gastrocnemius muscle fibers were analyzed. Three weeks after surgery, there were no differences in coupled mitochondrial respiration (ATP synthesis) with pyruvate, malate, and succinate; proton leak respiration; or mitochondrial reactive oxygen species production. However, after 3 wk of OVX, the soleus and white gastrocnemius muscles of the OVX animals showed a lower use of palmitoyl-carnitine and glycerol-phosphate substrates, respectively, and decreased peroxisome proliferator-activated receptor-γ coactivator-1α expression. Estrogen replacement reverted all of these phenotypes. Eight weeks after OVX, ATP synthesis was lower in the soleus and white gastrocnemius muscles of the OVX animals than in the sham-operated and estrogen-treated animals; however, when normalized by citrate synthase activity, these differences disappeared, indicating a lower muscle mitochondria content. No differences were observed in the proton leak parameter. Mitochondrial alterations did not impair the treadmill exercise capacity of the OVX animals. However, blood lactate levels in the OVX animals were higher after the physical test, indicating a compensatory extramitochondrial ATP synthesis system, but this phenotype was reverted by estrogen replacement. These results suggest early mitochondrial dysfunction related to lipid substrate use, which could be associated with the development of the overweight phenotype of ovariectomized animals.

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“…The lack of ovarian hormones in female adult rats leads to a signifi cant increase in body mass [ 1 , 2 ] , and overweight is rapidly established at the fi rst 2 weeks after ovariectomy, as shown by Percegoni et al [ 3 ] . Hence, ovariectomy in rats is widely used to study the physiological mechanisms that underlie obesity associated with ovarian hormones defi ciency [ 4 ] .…”

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confidence: 99%

Blunted Response of Pituitary Type 1 and Brown Adipose Tissue Type 2 Deiodinases to Swimming Training in Ovariectomized Rats

et al. 2012

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Ovariectomy leads to significant increase in body weight, but the possible peripheral mechanisms involved in weight gain are still unknown. Since exercise and thyroid hormones modulate energy balance, we aimed to study the effect of swimming training on body weight gain and brown adipose tissue (BAT) type 2 iodothyronine deiodinase responses in ovariectomized (Ox) or sham-operated (Sh) rats. Rats were submitted to a period of 8-week training, 5 days per week with progressive higher duration of exercise protocol. Swimming training program did not totally prevent the higher body mass gain that follows ovariectomy in rats (16.5% decrease in body mass gain in Ox trained rats compared to 22% decrease in sham operated trained animals, in relation to the respective sedentary groups), but training of Ox animals impaired the accumulation of subcutaneous fat pads. Interestingly, swimming training upregulates pituitary type 1 (p<0.001 vs. all groups) and BAT type 2 iodothyronine deiodinases (p<0.05 vs. ShS and OxS) in sham operated but not in Ox rats, indicating an impaired pituitary and peripheral response to exercise in Ox rats. However, BAT mitochondrial O2 consumption significantly increased by swimming training in both sham and Ox groups, indicating that Ox BAT mitochondria responds normally to exercise stimulus, but does not result in a significant reduction of body weight. In conclusion, increased body mass gain produced by Ox is not completely impaired by 8 weeks of high intensity physical training, showing that these animals sustain higher rate of body mass gain independent of being submitted to higher energy expenditure.

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Profile of Serum IL-1β and IL-10 Shortly after Ovariectomy and Estradiol Replacement in Rats

Cited by 21 publications

References 21 publications

Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

Role of estrogen on skeletal muscle mitochondrial function in ovariectomized rats: a time course study in different fiber types

Blunted Response of Pituitary Type 1 and Brown Adipose Tissue Type 2 Deiodinases to Swimming Training in Ovariectomized Rats

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