2012
DOI: 10.1055/s-0032-1314875
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Blunted Response of Pituitary Type 1 and Brown Adipose Tissue Type 2 Deiodinases to Swimming Training in Ovariectomized Rats

Abstract: Ovariectomy leads to significant increase in body weight, but the possible peripheral mechanisms involved in weight gain are still unknown. Since exercise and thyroid hormones modulate energy balance, we aimed to study the effect of swimming training on body weight gain and brown adipose tissue (BAT) type 2 iodothyronine deiodinase responses in ovariectomized (Ox) or sham-operated (Sh) rats. Rats were submitted to a period of 8-week training, 5 days per week with progressive higher duration of exercise protoco… Show more

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Cited by 27 publications
(40 citation statements)
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“…The training also increased the amount of UCP1 antigen in BAT compared with that of the sedentary controls. Other studies examining the effects of 6-8 weeks of swim training in rodents have reported increased blood flow to BAT (Hirata, 1982), increased mitochondrial activity (Ignacio et al, 2012), and increased type 2 deiodinase (dio2) enzymatic activity and mitochondrial respiration in BAT (Ignacio et al, 2012). Rodents that experienced other exercise modalities, including 6-8 weeks of treadmill training, showed an increase in BAT activity: for example, increased cytochrome oxidase activity (Yoshioka et al, 1989), increased oxygen consumption rates (Yoshioka et al, 1989) and upregulation of BAT-specific gene markers (Yoshioka et al, 1989;Xu et al, 2011Xu et al, , 2012.…”
Section: Exercise Increases Bat Mitochondrial Activitymentioning
confidence: 89%
See 1 more Smart Citation
“…The training also increased the amount of UCP1 antigen in BAT compared with that of the sedentary controls. Other studies examining the effects of 6-8 weeks of swim training in rodents have reported increased blood flow to BAT (Hirata, 1982), increased mitochondrial activity (Ignacio et al, 2012), and increased type 2 deiodinase (dio2) enzymatic activity and mitochondrial respiration in BAT (Ignacio et al, 2012). Rodents that experienced other exercise modalities, including 6-8 weeks of treadmill training, showed an increase in BAT activity: for example, increased cytochrome oxidase activity (Yoshioka et al, 1989), increased oxygen consumption rates (Yoshioka et al, 1989) and upregulation of BAT-specific gene markers (Yoshioka et al, 1989;Xu et al, 2011Xu et al, , 2012.…”
Section: Exercise Increases Bat Mitochondrial Activitymentioning
confidence: 89%
“…However, studies investigating the effects of exercise on BAT have yielded conflicting results (Stanford and Goodyear, 2016). In some studies, investigators have shown an increase in mitochondrial activity in rodent BAT (Ignacio et al, 2012;Yoshioka et al, 1989), whereas other studies have revealed a decrease in mitochondrial activity (Wu et al, 2014) and glucose uptake in BAT in exercise-trained humans (Vosselman et al, 2015;Motiani et al, 2017). Exercise has also been shown to affect the composition and concentration of phospholipids and triglycerides in the lipidome of rodent BAT (May et al, 2017).…”
Section: The Curious Effects Of Exercise On Batmentioning
confidence: 99%
“…Several rodent models demonstrate that, when maintained under sedentary conditions and fed normal low-fat rodent chow diet, OVX is followed by rapid weight gain in the form of WAT (15,40,48). To our knowledge, no studies have shown protection from OVX-associated weight gain and/or insulin resistance in the absence of intervention.…”
Section: Discussionmentioning
confidence: 99%
“…2). Some studies have demonstrated increased BAT activity with exercise, [61][62][63][64][65][66] others showed no change in BAT activity, [67][68][69][70] while a third set of studies reported a decrease in BAT activity with exercise. 32,[71][72][73][74] Exercise increases BAT activity Studies in rats have demonstrated that 6-8 wks of swim training for 2-3 hours per day resulted in increased blood flow to BAT and increased responsiveness to norepinephrine stimulation.…”
Section: Exercise Effects On Brown Adipose Tissue Activitymentioning
confidence: 99%
“…63,64 Another study demonstrated that 8 wks of exercise training by swimming significantly increased BAT mitochondrial activity in rats. 61 In this study, rats were subjected to an exercise training protocol where they swam in a thermoneutral (31-33 C), 1 gallon, plastic barrel for up to 75 minutes per day. While training did not alter total body weight or food intake, retroperitoneal adipose tissue mass was significantly decreased in response to exercise.…”
Section: Exercise Effects On Brown Adipose Tissue Activitymentioning
confidence: 99%