Profile of patients with hepatocellular carcinoma: An experience from a tertiary care center in India

Musunuri, Balaji; Shetty, Shiran; Bhat, Ganesh; Udupa, Karthik S; Pai, Ananth

doi:10.1007/s12664-021-01209-0

Cited by 17 publications

(9 citation statements)

References 33 publications

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“…This is a disease that affects young adults, confirming the results reported by Nnadi et al [10] in Nigeria (48.16±16.55 years) and Nsondé et al [11] in Gabon (45.02±12.3 years). However, a higher average age is reported by Musunuri et al [12] in India (62.8 years) and Trybus et al [13] in Brazil (61 years). This difference could be explained by the fact that India and Brazil have a more developed health system promoting better access to treatment and, in turn, an increase in patient survival.…”

Section: Discussionmentioning

confidence: 72%

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

ALASSANI¹,

DOVONOU²,

SAKE³

et al. 2023

World J. Adv. Res. Rev.

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Introduction: Cancer is a global public health problem. This study focused on the the profile of people living with cancer in Parakou. Study method: This was a cross-sectional, descriptive and analytical study which enrolled people living with cancer followed in the palliative heath care of the internal medicine unit at the Regional University Health Center of Borgou who had given their consent. The variables of the study were: sociodemographic data, nutritional status, comorbidities, circumstances of cancer screening and their location. Data analysis was performed using Epi Data 3.1 software. Results: The study population consisted of 264 people with cancer. A male predominance was observed with a sex ratio of 2.66. The average age was 47.51 years ±13.20. Alcohol consumption was observed in 15.2%. Arterial hypertension was found in 63.6% of subjects. On the nutritional level, malnutrition and weight loss were observed respectively in 68.2% and 98.1% of patients. Abdominal pain, asthenia and weight loss were the main circumstances for cancer screening and were present in 37.1%, 27.6% and 16.7% of participants respectively. Liver cancer was found in the majority (72%) of the participants. Viral hepatitis B was the most common cause with 98.3% Conclusion: cancer affects young adults and is often detected at an advanced stage. The main site is the liver and infection with the hepatitis B virus is found in most of the cases.

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Section: Discussionmentioning

confidence: 72%

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

ALASSANI¹,

DOVONOU²,

SAKE³

et al. 2023

World J. Adv. Res. Rev.

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“…Consistently, Bhatti et al 11 reported that the patients' average age was 57.9 ± 10.1 years and males were in the majority with a male-to-female ratio of 2.8:1. On the other hand, in the study of Kumar K et al 11 13 reported that the Child-Pugh group B was the most common, followed by category A in 45.4% and 41% of the individuals, correspondingly. In the study of Choudhry, A et al 14 reported that the child Pugh class B was most common in 40.2% of the cases, followed by class A 39.2% and class 20.6%.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Liver Function Among Patients Presented with Hepatocellular Carcinoma

Lakho¹,

Singh²,

Memon³

et al. 2022

PJMHS

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Objective: To determine the liver function assessment in the patients presented with hepatocellular carcinoma. Methodology: This cross-sectional study was done at the gastroenterology departments of Liaquat University Hospital Hyderabad and Indus Medical College TM Khan. Patients with an age range of 20 to 70 years, both genders, and having hepatocellular carcinoma were included in the study. A 5 mL blood sample was taken from each participant and sent to the hospital diagnostic laboratory to assess the serum bilirubin level and albumin level. The albumin-bilirubin (ALBI) score was used for hepatic function. Data was collected using a self-made research proforma, and it was analyzed using SPSS 26. Results: A total of 58 cases having HCC were assessed regarding hepatic function. The mean age of the patients was 55.39+12.39 years. Males were in the majority 75.9%, and females were 24.1%. The majority of the patients (72.4%) had child Pugh class C, 12.1% had child Pugh class B, and 15.5% of the cases had child Pugh class A. Elevated bilirubin levels of albumin levels and Alpha-fetoprotein levels were significantly associated to the child Pugh class C (p= <0.05). Most of the cases, 67.3%, had an ALBI score > − 1.39, 10.3% cases had ALBI score − 2.59 to − 1.39, and 22.4% of patients had an ALBI score ≤ − 2.60. Conclusion: Severe hepatic dysfunction was observed to be frequently high among patients having hepatocellular carcinoma, as most of the cases had Pugh class C and ALBI stage 3. Due to the extremely small sample size used in this study, the results are not trustworthy. Keywords: HCC, Hepatic function, Bilirubin, Albumin, ALBI

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“…29 Overall, geographical differences which in turn result in variations in prevalence of various etiological risk-factors for HCC might have an impact on their attribution fractions. 30…”

Section: Discussionmentioning

confidence: 99%

Etiologic fractions in patients of hepatocellular carcinoma in India with and without a background of cirrhosis: a multi-centric study

et al. 2023

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Background: Hepatocellular cancer (HCC) typically arises in the background of cirrhosis. Its epidemiology has been changing due to availability of antivirals, changing life-styles and early detection. We undertook a multicentric national sentinel surveillance for liver cirrhosis and HCC to assess the attributable risk factors for development of HCC, both with and without a background of cirrhosis.Methods: Data from January 2017 till August 2022 from hospital-based records of eleven participating centres was included. Diagnosed cases of cirrhosis [radiological (multiphase and/or histopathological] and HCC [as per AASLD 2018] were included. History of signi cant alcohol intake was elicited by AUDIT-C questionnaire.Results: Altogether 5798 enrolled patients were assessed, of which 2664 patients had HCC. The mean age was 58.2±11.7 years and 84.3% (n=2247) were males. Diabetes was found in over a third of those with HCC (n=1032;39.5%). The most common etiology of HCC was NAFLD (n=927;35.5%) followed by viral hepatitis B and C and harmful levels of alcohol. Among those with HCC, 27.9% (n=744) had no cirrhosis. Higher proportion of cirrhotic HCC patients had alcohol as an etiological factor as compared to non-cirrhotic (17.5% Vs 4.7%, p= <0.001). NAFLD was an etiological factor for a higher proportion of noncirrhotic HCC patients as compared to cirrhotic HCC (48.2% Vs 30.6%, p=< 0.001). Diabetics more commonly had non-cirrhotic HCC (50.5% vs 35.2%). The odds of having cirrhotic HCC was 1.409 times greater for >60 years, 1.372 times for males and 3.472 times for harmful alcohol consumption. Those with NAFLD were 1.553 times more likely to develop non-cirrhotic HCC.Conclusion: This large multi-centric study demonstrates that NAFLD is the most important risk factor for development of both cirrhotic and non-cirrhotic HCC in India and has overtaken viral hepatitis. Awareness campaigns and large-scale screening are required to reduce the high burden of NAFLD related HCC in India.

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Profile of patients with hepatocellular carcinoma: An experience from a tertiary care center in India

Cited by 17 publications

References 33 publications

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021

Evaluation of Liver Function Among Patients Presented with Hepatocellular Carcinoma

Etiologic fractions in patients of hepatocellular carcinoma in India with and without a background of cirrhosis: a multi-centric study

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