Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India

Alagarasu, Kalichamy; Bachal, Rupali; Shah, P.S.; Cecilia, D.

doi:10.1111/iji.12231

Cited by 8 publications

(9 citation statements)

References 34 publications

(37 reference statements)

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“…For this reason, the difference in KIR2DL3 expression should also be interpreted with caution. Although KIRs have been implicated in dengue disease severity (47)(48)(49), whether the expression of KIRs on CD8 + T cells has any functional role in anti-DENV immunity warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Tian¹,

Babor²,

Lane³

et al. 2019

Journal of Clinical Investigation

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Section: Discussionmentioning

confidence: 99%

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Tian¹,

Babor²,

Lane³

et al. 2019

Journal of Clinical Investigation

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“…More recently, there is genetic evidence that supports the role of KIRs in DENV infections as well. In studies done in Gabon, Brazil and in Western India, a difference in the frequencies of KIR genes such as KIR3DL1, KIR3DS1, KIR2DS1, KIR2DS5 and KIR2DL5 was found in patients with dengue compared with healthy controls . Furthermore, the analysis in one study found a possible protective effect against dengue fever in individuals with the AA genotype.…”

Section: Killer Cell Immunoglobulin‐like Receptor Interactions With Denvmentioning

confidence: 97%

Defining the role of NK cells during dengue virus infection

Mathew

2018

Immunology

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In recent years, our understanding of the complex number of signals that need to be integrated between a diverse number of receptors present on natural killer (NK) cells and ligands present on target cells has improved. Here, we review the progress made in identifying interactions between dengue viral peptides presented on HLA Class 1 molecules with inhibitory and activating killer-like immunoglobulin receptors on NK cells, direct interactions of viral proteins with NK cell receptors, the involvement of dengue virus-specific antibodies in mediating antibody-dependent cell-mediated cytotoxicity and the role of soluble factors in modulating NK cell responses. We discuss findings of NK cell activation early after natural dengue infection, and point to the role that NK cells may play in regulating both innate and adaptive immune responses, in the context of our new appreciation of interactions of dengue virus with specific NK cell receptors. With a number of flavivirus vaccine candidates in clinical trials, how NK cells respond to attenuated dengue virus and subunit protein vaccine candidates and shape adaptive immunity will need to be considered.

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“…In parallel, genetic evidence supports the role of KIRs in flavivirus infection. In studies performed in Gabon, Brazil and Western India, a difference in the frequencies of KIR genes was found in patients infected with DENV, as compared with healthy controls [33,79,80]. Mechanistically, KIR molecules interact with DENV peptides presented on HLA molecules.…”

Section: Nk Cell Responses Following Arbovirus Infectionmentioning

confidence: 99%

Control of Acute Arboviral Infection by Natural Killer Cells

Maucourant

Petitdemange

Yssel

et al. 2019

Viruses

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The recent explosive pandemic of chikungunya virus (CHIKV) followed by Zika (ZIKV) virus infections occurring throughout many countries represents the most unexpected arrival of arthropod-borne viral diseases in the past 20 years. Transmitted through the bite of Aedes mosquitoes, the clinical picture associated with these acute arbovirus infections, including Dengue (DENV), CHIKV and ZIKV, ranges from classical febrile illness to life-threatening disease. Whereas ZIKV and CHIKV-mediated infections have previously been recognized as relatively benign diseases, in contrast to Dengue fever, recent epidemic events have brought waves of increased morbidity and mortality leading to a serious public health problem. Although the host immune response plays a crucial role in controlling infections, it may also promote viral spread and immunopathology. Here, we review recent developments in our understanding of the immune response, with an emphasis on the early antiviral immune response mediated by natural killer cells and emphasize their Janus-faced effects in the control of arbovirus infection and pathogenesis. Improving our understanding knowledge on of the mechanisms that control viral infection is crucial in the current race against the globalization of arbovirus epidemics.

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Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India

Cited by 8 publications

References 34 publications

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Defining the role of NK cells during dengue virus infection

Control of Acute Arboviral Infection by Natural Killer Cells

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