Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Tian, Yuan; Babor, Mariana; Lane, Jerome C.; Seumois, Grégory; Liang, Shu; Goonawardhana, N.D. Suraj; Silva, Aruna Dharshan De; Phillips, Elizabeth; Mallal, S.; Antunes, Ricardo da Silva; Grifoni, Alba; Vijayanand, Pandurangan; Weiskopf, Daniela; Peters, Bjoern; Sette, Alessandro

doi:10.1172/jci123726

Cited by 39 publications

(51 citation statements)

References 69 publications

(87 reference statements)

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“…In terms of CD8 T cells, our group recently characterized the transcriptomic profiles of DENV‐specific memory CD8 T‐cell subsets. It was previously demonstrated that DENV‐specific CD8 T cells can be found predominantly in the two effector memory CD8 T‐cell subsets (Tem and Temra) . DENV‐specific Tem and especially Temra cells have highly specialized gene expression programs and up‐regulated genes related to T‐cell activation, co‐stimulation, and effector functions .…”

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

“…It was previously demonstrated that DENV‐specific CD8 T cells can be found predominantly in the two effector memory CD8 T‐cell subsets (Tem and Temra) . DENV‐specific Tem and especially Temra cells have highly specialized gene expression programs and up‐regulated genes related to T‐cell activation, co‐stimulation, and effector functions . DENV‐specific CD8 T cells from both effector memory subsets responded to DENV‐specific stimuli by producing IFN‐ γ in association with genes involved in activation and cytotoxicity, such as CD69 , CD160 , CRTAM , SLAMF7 , TNFRSF9 , TNF , CCL3 , CCL4 , and GZMB , XCL1 , and XCL2 .…”

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

“…DENV‐specific Tem and especially Temra cells have highly specialized gene expression programs and up‐regulated genes related to T‐cell activation, co‐stimulation, and effector functions . DENV‐specific CD8 T cells from both effector memory subsets responded to DENV‐specific stimuli by producing IFN‐ γ in association with genes involved in activation and cytotoxicity, such as CD69 , CD160 , CRTAM , SLAMF7 , TNFRSF9 , TNF , CCL3 , CCL4 , and GZMB , XCL1 , and XCL2 . Additionally, DENV‐specific Temra cells express a few killer cell immunoglobulin‐like receptor (KIR) genes including KIR2DL3 , which are innate immunity signatures and are expressed on natural killer cells .…”

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

“…DENV‐specific CD8 T cells from both effector memory subsets responded to DENV‐specific stimuli by producing IFN‐ γ in association with genes involved in activation and cytotoxicity, such as CD69 , CD160 , CRTAM , SLAMF7 , TNFRSF9 , TNF , CCL3 , CCL4 , and GZMB , XCL1 , and XCL2 . Additionally, DENV‐specific Temra cells express a few killer cell immunoglobulin‐like receptor (KIR) genes including KIR2DL3 , which are innate immunity signatures and are expressed on natural killer cells . In addition, DENV‐specific CD8 T cells showed preferential usage of TCR β ‐chain variable (TRBV) genes such as TRBV7‐9 and TRBV7‐8, pointing to a clonally expanded TCR repertoire.…”

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

“…Additionally, DENV‐specific Temra cells express a few killer cell immunoglobulin‐like receptor (KIR) genes including KIR2DL3 , which are innate immunity signatures and are expressed on natural killer cells . In addition, DENV‐specific CD8 T cells showed preferential usage of TCR β ‐chain variable (TRBV) genes such as TRBV7‐9 and TRBV7‐8, pointing to a clonally expanded TCR repertoire.…”

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

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Transcriptomic immune profiles of human flavivirus‐specific T‐cell responses

et al. 2020

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The Flavivirus genus of viruses includes dengue (DENV), Zika (ZIKV), yellow fever (YFV), Japanese encephalitis (JEV), and West Nile (WNV) viruses. Infections with these species combined are prevalent in tropical and sub-tropical areas, affecting millions of people and ranging from asymptomatic to severe forms of the disease. They therefore pose a serious threat to global public health. Several studies imply a role for T cells in the protection but also pathogenesis against the different flavivirus species. Identifying flavivirus-specific T-cell immune profiles and determining how pre-exposure of one species might affect the immune response against subsequent infections from other species is important to further define the role of T cells in the immune response against infection. Understanding the immune profiles of the flavivirus-specific T-cell response in natural infection is important to understand the T-cell response in the context of vaccination. In this review, we summarize the current knowledge on human immune profiles of flavivirus-specific T-cell reactivity, comparing natural infection with the acute form of the disease and vaccination in different flavivirus infections.

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Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

Section: Flavivirus T‐cell Responses In Natural Immunity As a Model Tmentioning

confidence: 99%

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Transcriptomic immune profiles of human flavivirus‐specific T‐cell responses

et al. 2020

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Progress and applications of mass cytometry in sketching immune landscapes

Zhang

Warden

2020

Clinical & Translational Med

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Recently emerged mass cytometry (cytometry by time-of-flight [CyTOF]) technology permits the identification and quantification of inherently diverse cellular systems, and the simultaneous measurement of functional attributes at the single-cell resolution. By virtue of its multiplex ability with limited need for compensation, CyTOF has led a critical role in immunological research fields. Here, we present an overview of CyTOF, including the introduction of CyTOF principle and advantages that make it a standalone tool in deciphering immune mysteries. We then discuss the functional assays, introduce the bioinformatics to interpret the data yield via CyTOF, and depict the emerging clinical and research applications of CyTOF technology in sketching immune landscape in a wide variety of diseases.

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Identification and selection of immunodominant B and T cell epitopes for dengue multi-epitope-based vaccine

Lim

Poh

2021

Med Microbiol Immunol

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Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Cited by 39 publications

References 69 publications

Transcriptomic immune profiles of human flavivirus‐specific T‐cell responses

Transcriptomic immune profiles of human flavivirus‐specific T‐cell responses

Progress and applications of mass cytometry in sketching immune landscapes

Identification and selection of immunodominant B and T cell epitopes for dengue multi-epitope-based vaccine

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