Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports

When the Creation of a Consortium Provides Useful Answers: Experience of The Latin American DILI Network (LATINDILIN)

“…Data on patients with DILI in Latin America have been historically scarce, usually coming from case reports or small series of patients because there was no specific structure that could allow tackling these scientific challenges in an efficient and collaborative way. With this perspective in mind, the LATINDILIN initiative set up a network of hepatologists working on the same structured protocol to collect relevant information and to establish causality with confidence.…”

Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy

“…A retrospective review of ALF in Germany reported phenprocoumon, a coumarin derivative, as the predominant cause of iDILI ALF . In Latin America, flutamide, cyproterone acetate and nimesulide are responsible for the majority of iDILI ALF . Anti‐tuberculosis therapy is the most common iDILI‐associated ALF in South Asia and the developing world, probably related to more frequent need for these agents in endemic areas …”

“…42 In Latin America, flutamide, cyproterone acetate and nimesulide are responsible for the majority of iDILI ALF. 43 Anti-tuberculosis therapy is the most common iDILI-associated ALF in South Asia and the developing world, probably related to more frequent need for these agents in endemic areas. 44 Up to a quarter of iDILI because of tuberculosis treatment progresses to ALF with high mortality rate.…”

Prospective Monitoring of Drug Use: Drug-Induced Liver Injury in a Primary Healthcare Center

“…The culprit drugs found in the present study were already mentioned in others studies. Among them, AINES is the most common responsible agent of DILI in Latin America, with an incidence of 32% (62/171) (14) . In addition, nimesulide was the anti-inflammatory which most caused DILI in an Italian Center, responsible for 82% of cases in a period of ten years (14/17) (15) .…”