Profile of gross congenital malformations among live newborns and its associated risk factors from a tertiary care rural teaching institute

Marwah, Ashish; Marwah, Poonam

doi:10.18203/2320-6012.ijrms20161820

Cited by 4 publications

(8 citation statements)

References 6 publications

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“…18 Similarly, Devi et al(2018) also found the most common system to be musculoskeletal system. 10 Although the most common anomaly found in their study was cleft lip (17.6%) followed by CTEV (13.2%).Anomaly wise in our study, CTEV (27.4%) was most common followed by meningomyelocele and meningocele (11.2%), cleft palate (6.4%) and tracheoesophageal fistula (5.6%).Studies by Marwahetal, Patel et al reported higher incidence of CNS malformations, 13,20 whereas Taksande et al, Padmanabhan et al, Patel et al 11,20,21 reported CVS malformations as the most common system. CVS defects emerged as the most common CBDs in Pune urban birth defect study (PUBOS) too.…”

Section: Discussionmentioning

confidence: 41%

“…26 However few studies like by Marwah et al, Sarkar et al, Sachdeva et al found multiparous mothers have more cases of CBDs. 13,15,18 In our study, proportion of caesarean section deliveries were equal among the two groups. Whereas, there are few Indian studies in which higher incidence of malformation was seen in babies born by caesarean section.…”

Section: Discussionmentioning

confidence: 54%

“…Marwah et al, Doddabasappa et al 13,14 from India reported the incidence of 1.7% and Sachdeva et al to be 1.6%. 15 A study from North Kerala reported incidence of 0.84%.…”

Section: Discussionmentioning

confidence: 95%

“…18 Few Indian studies reported a higher incidence of CBDs among mothers aged over 35 years, though it was statistically insignificant. 13,15,25 So most of the Indian studies have not found any significant association of increased maternal age with the CBDs. In our study, increased parity was also not associated with CBD.…”

Section: Discussionmentioning

confidence: 98%

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Profile of neonates born with congenital birth defects in a tertiary care hospital of North India: An observational study

Sinha

Tripathi

Nigam

et al. 2022

Clinical Epidemiology and Global Health

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Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 54%

“…Marwah et al, Doddabasappa et al 13,14 from India reported the incidence of 1.7% and Sachdeva et al to be 1.6%. 15 A study from North Kerala reported incidence of 0.84%.…”

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Profile of neonates born with congenital birth defects in a tertiary care hospital of North India: An observational study

Sinha

Tripathi

Nigam

et al. 2022

Clinical Epidemiology and Global Health

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“…Although the etiology is unknown in 50% of cases, genetic (30-40%) and environmental (5-10%) components prevail among the majority of known causes [2].…”

Section: Research Relation To the Programs Plans And Department Thementioning

confidence: 99%

The Frequency and Structure of Congenital Malformations in Rural Populations of Southern Ukraine and the Role of Genetic and Demographic Factors in their Distribution

Лановенко¹,

Fomina²

2020

Ukr. ž. med. bìol. sportu

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In modern conditions of constant population decline and the presence of adverse demographic processes in Ukraine, the urgent task is to identify the most significant genetic and demographic factors affecting the adaptation of the population, as well as monitoring changes in the volume and structure of the genetic load caused by congenital pathology. The frequency of congenital malformations of newborns in the Kherson region increased (from 22.3±5.4 % in 2000-2008 to 40.1 ± 8.2 % in 2009-2017). In recent years, there has been a statistically significant increase in the frequency of hereditary pathology of newborns among the rural population of the region (from 1.09 to 1.95 %).The total frequency of congenital malformations increased in almost all areas of the Kherson region (from 20.2±1.4, 27 to 27.6±1.3 %) and averaged 30.2±6.4 %. Significant differences in this indicator were found between some nations of the region. Malformations of the circulatory system (28.5 %), musculoskeletal system (26.05 %) and the genitourinary system (15.25 %) occupy a leading place in the structure of congenital pathology. The prevalence of congenital malformations is inversely correlated with the prevalence of spontaneous miscarriages (r =-0.52± ±0.12; tr=2.4> t05=2.12), which indicates the presence of a screening effect that eliminates non-viable genotypes in embryonic period of ontogenesis.Rural population where the share of interethnic marriages has increased over the years of research, is characterized by a higher prevalence of congenital malformations (r=0.50±0.46; t=2.3>t05=2.12). In population (with an endogamy index of 0.5 and higher), an increase or relative constancy of the proportion of homolocal mono-ethnic Ukrainian marriages and a lower prevalence of congenital malformations among newborns are observed. The level of endogamy does not significantly affect the prevalence of malformations (r=-0.20±0.24; tr=0.8

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Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study

Garg

Dasari

Ali

2021

Journal of Fetal Medicine

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Background Though this is an era of imaging, many women with fetal congenital malformations are presenting beyond 20 weeks of pregnancy posing problems in decision making. This study was undertaken to determine the prevalence of congenital fetal malformations presenting to tertiary health care and to analyse the gestational age at presentation and spectrum of malformations and the clinical and socio-demographic factors. Material and Methods This was a retrospective analysis of hospitalised women with diagnosis of congenital fetal malformations (CFM) from January 2017 to December 2017. The data was retrieved from Medical Records Section after due permissions and analysed with respect to socio-demographic status, age, consanguinity, type of congenital anomaly and gestational age at presentation. Results The prevalence of CFM was 1.56%. The majority (64%) of CFM were detected during the second trimester and 27% were detected in the 3rd trimester. The most common anomalies were CNS followed by multiple anomalies and 72% and 65% of them were live born respectively. The majority (90%) belonged to lower middle socioeconomic group and were from rural background (82%). The majority of women were less than 30 years of age (77.6%) and 38% were primigravidae. Consanguinity was present in 34%, medical disorders were associated in 29% and 3% had family history of congenital fetal anomalies. ConclusionThe most common anomalies were CNS and majority were primigravidae. The most common medical disorder associated was diabetes. It is possible that they are deficient in folic acid and vitamin B12. Hence pre-conceptional control of medical disorders, nutritional counselling regarding intake of micronutrients and awareness programmes to take pre-conceptional folic acid and vitamin B12 are the need of the hour for prevention.

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Profile of gross congenital malformations among live newborns and its associated risk factors from a tertiary care rural teaching institute

Cited by 4 publications

References 6 publications

Profile of neonates born with congenital birth defects in a tertiary care hospital of North India: An observational study

Profile of neonates born with congenital birth defects in a tertiary care hospital of North India: An observational study

The Frequency and Structure of Congenital Malformations in Rural Populations of Southern Ukraine and the Role of Genetic and Demographic Factors in their Distribution

Clinical Profile of Women with Congenital Fetal Malformations: A Retrospective Cohort Study

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