Profile of gallbladder diseases diagnosed at afyon kocatepe university: a retrospective study

Abstract

Objective: Superficial tumors including Ta, Tis, and T1 make up 75% of urothelial carcinomas of the bladder. While the behavior of these superficial urothelial cancers is relatively benign, invasive tumors have a significant mortality rate. However, Ta and T1 tumors might display different biological behavior. There is therefore a great need for biomarkers that can accurately distinguish the behavior of urothelial carcinomas in addition to tumor grade and stage. our aim was to determine the immunohistochemical expression profile of insulin like growth factor ii mrna binding Protein 3 (iMP3) and its correlation with tumor stage and grade in benign urothelium and bladder urothelial carcinomas. Material and Method: The expression of iMP3 in 91 patients with benign urothelium (20 cases), low grade invasive (17 cases) / non-invasive (20 cases) urothelial carcinoma and high grade invasive (20 cases) / non-invasive (14 cases) urothelial carcinoma was evaluated by immunohistochemistry in this study. Results: iMP3 was not expressed in benign urothelium, low-grade non-invasive urothelial carcinoma and high grade non-invasive urothelial carcinoma. Expression of iMP3 was found in 11.76% of low-grade invasive urothelial carcinomas and 55% of high grade invasive urothelial carcinomas. Statistical analysis including χ2 tests showed that iMP3 expression of invasive urothelial carcinomas was statistically significant (p<0.000). Conclusion: The detection of iMP3 only in invasive carcinomas although some of them were low grade showed that the expression of iMP3 may be related to aggressive behavior of urothelial carcinomas. ÖZ Amaç: Ürotelyal karsinomların %75'i yüzeyel tümörler olarak Ta, Tis ve T1 şeklinde karşımıza çıkmaktadır. Yüzeyel tümörler benign davranış gösterirken, invaziv tümörlerde ise yüksek mortalite oranı bildirilmiştir. Bununla birlikte, Ta ve T1 tümörler, farklı biyolojik davranışlar sergileyebilmektedirler. Bu durum, ürotelyal karsinomların davranışının belirlenmesinde, histopatolojik evre ve dereceye ek olarak, bazı biyolojik belirteçlere ihtiyaç olduğunu göstermektedir. Bu çalışmada amacımız, benign ürotelyum ile mesanenin ürotelyal karsinomlarında insulin like growth factor ii mrna binding Protein 3 (iMP3) ekspresyon profilini belirleyerek, tümörün histopatolojik evresi ve derecesi ile ilişkisini saptamaktır. Gereç ve Yöntem: Bu çalışmada 91 hastaya ait benign ürotelyum (20 olgu), düşük dereceli invaziv (17 olgu) / non-invaziv (20 olgu) ürotelyal karsinom ve yüksek dereceli invaziv (20 olgu) / non-invaziv (14 olgu) ürotelyal karsinom tanısı almış olgular immünohistokimyasal olarak iMP3 ekspresyonu açısından değerlendirildi. Bulgular: Benign ürotelyum, düşük dereceli non-invaziv ürotelyal karsinom ve yüksek dereceli non-invaziv ürotelyal karsinom tanısı almış olgularda iMP3 ekspresyonu saptanmadı. Düşük dereceli invaziv ürotelyal karsinom olgularının %11,76'sında, yüksek dereceli invaziv ürotelyal karsinom olgularının %55'inde iMP3 ekspresyonu saptandı. χ2 testi ile yapılan istatistiksel analizde, invaziv tümö...

Do histopathologic findings improve by increasing the sample size in cholecystectomies?

“…These ratios were higher when compared to the Mazlum et al . study, which reported 13.3% of cholesterolosis cases from the Western part of Turkey [10]. Parallel to our study, Bolat et al .…”

“…Cholesterol polyps are one of the most frequent types stated in various studies [10,12,13]. Similar to the literature, we detected 16 (3.2%) polyps in Group 2 with the increased sample size, and 11 (2.5%) of those were cholesterol polyps.…”

“…In contrast to this study, Mazlum et al . observed metaplasia in 18 out of 24 dysplastic gallbladders either adjacent to or within the dysplastic epithelium [10]. Meirelles-Costa et al .…”

Gallstones and Concomitant GastricHelicobacter pyloriInfection

“…One sample was used for the rapid urease test (Pronto Dry), the second for aerobic and anaerobic culture, and the third for histopathologic evaluation. Gallstones were classified as cholesterol, pigment, and mixed stones based on their color and consistency [14, 15]. …”

Clinicopathological profile ofcholecystectomy specimens-aretrospective and prospective study

“…of age.Mohan et al [11] found that the age of the patients varied from 10 to 90years with maximum number of cases between 31 and 40 years of age. Mazlum M et al [12] also noted male to female ratio being 1:2.33. Singh A 13], Raza [14] and Udwadia [15] found the maximum incidence in the age group between 3 rd to 5 th decades.…”