Profile of DNA Damage Protective Effect and Antioxidant Activity of Different Solvent Extracts from the Pericarp of Garcinia Mangostana

Abstract

Abstract:The content of total polyphenols, DNA damage protective effect, and antioxidant activity of different solvent extracts including hexane, acetidin (ethyl acetate), acetone, ethanol, and methanol) from Garcinia mangostana pericarp were investigated and compared. The results showed that the content of total polyphenols is significantly affected by extracting solvents, and resulting in variation of antioxidant activities of Garcinia mangostana pericarp. Methanol, acetone, and ethanol extracts exhibited the better DNA protective effect, the same as that of 100 µM of Trolox. The methanol extract exhibited the strongest antioxidant activities because it possessed the highest total polyphenols content, followed by acetone and ethanol extracts, while other extracts had both lower the content of active compounds and bioactivities. These results indicated that selective extraction from Garcinia mangostana pericarp, by an appropriate solvent, is important for obtaining fractions with high antioxidant activity, which will be useful for the developing and application of mangosteen pericarp as a new local source of bioactive compounds in foods and medicine industries.