Profile of Chromosomal Abnormalities in the Al Jahra Region of Kuwait

Abstract

Objective: One hundred and seventy-seven newborn babies with chromosomal abnormalities were studied at the Al-Jahra satellite clinic of the Kuwait Medical Genetics Centre (KMGC), Kuwait, over a 7-year period from January 1983 to December 1989 to make a reanalysis and recomputation of the statistical results of the previous short-term studies. Methods: The data were collected from the registry of chromosomal abnormalities and from the clinical records of the patients in KMGC retrospectively. Controls were selected from the newborn babies delivered in the same period of study. The logistic regression analysis was computed using dependent/independent variables. Results: Ninety-five percent of the cases had numerical chromosomal abnormalities, and 5% had structural chromosomal abnormalities. One hundred and forty-five cases had classic trisomy 21, with an incidence of 2.9/1,000 live births (LB), 16 cases had trisomy 18 (0.3/1,000 LB), 5 cases had trisomy 13 (0.1/1,000 LB), 1 case had triploidy 69, XXY (0.02/1,000 LB) and 1 had Turner’s syndrome (0.05/1,000 female LB). Nine cases with structural chromosomal abnormalities were enumerated, dir dup(1) (p21–p32), del(1)(q32–q42), del(13)(q22–q34) and inversion Y chromosome, the incidence was 0.02/1,000 LB for each. Two cases of translocation trisomy 21 (0.04/1,000 LB) and 3 cases of cri-du-chat (0.06/1,000 LB) were enumerated too. Bedouins had a double-fold increased risk of trisomy 21 (odds ratio = 1.819, p = 0.032), and advanced maternal age was also a risk factor while paternal age showed inconsistent pattern of risk. Conclusion: This study confirmed the high incidence of the common trisomies and the role of advanced maternal age and the Bedouin ethnicity as a risk factor.

Serological Immunomarkers in Cutaneous T Cell Lymphoma

“…Neopterin serum level was found to correlate positively with tumor stage and negatively with prognosis in several malignancies. In addition, it is elevated during transplant rejections, autoimmune diseases and viral infections like hepatitis or HIV [5]. Contrary to our finding that neopterin is significantly elevated only in Sézary patients, Hamerlinck [5]reported that neopterin is not elevated in Sézary but in later-stage MF patients.…”

“…In addition, it is elevated during transplant rejections, autoimmune diseases and viral infections like hepatitis or HIV [5]. Contrary to our finding that neopterin is significantly elevated only in Sézary patients, Hamerlinck [5]reported that neopterin is not elevated in Sézary but in later-stage MF patients. We observed an increase in neopterin levels with the tumor burden in non-leukemic CTCL like MF [7].…”

“…they might show an increase in eosinophils and serum IgE levels and a reduced cutaneous delayed-type hypersensitivity reaction due to the production of the Th-2 type cytokines IL-4, -5, -6 and -10 by the lymphoma cells [4]. This study aimed to investigate further serologic parameters: neopterin, β 2 -microglobulin (β 2 -MG), soluble IL-2 receptor (sIL2R) and IL-6, which have been found to be elevated in various other malignancies [5], and to determine if they are capable of differentiating between non-leukemic CTCL and Sézary patients, correlate with tumor stage and predict the clinical outcome of the disease.…”

Incidence of Down Syndrome in Dubai, UAE

“…The increased incidence of Down syndrome in Dubai is comparable to the reported incidences among Arab nationals from several other regions, namely Kuwait, Saudi Arabia, Qatar, Israel and Libya, which are in the range of 1.93-3.5/1,000 live births ( table 2 ) [9][10][11][12][13][14][15][16][17][18] . The incidence of 3.13/1,000 observed in the UAE population in Dubai is higher than most of the other Arab populations except for Kuwait, where it is reported to be between 2.9 and 3.50/1,000 [9,10] .…”

“…The incidence of 3.13/1,000 observed in the UAE population in Dubai is higher than most of the other Arab populations except for Kuwait, where it is reported to be between 2.9 and 3.50/1,000 [9,10] . The mean maternal age (33.48 8 8.08 years, range 17-54 years) in UAE nationals was lower compared to Egypt (38.2 years) and Qatar (35.4 8 6.5 years, range 21-51), but was slightly higher than that of Lebanon (32.19 years) [17][18][19] .…”