Genetic Disorders in Kuwait

Nanoscale Metal–Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy

“…[7][8][9][10] As highly conjugated analogues of porphyrins, phthalocyanines (PCs) possess several ideal properties as PSs: (1) strong absorption in the therapeutic window of PDT (650-800 nm) for reduced PS doses; (2) high triplet quantum yields and long triplet lifetimes in metalated PCs (M-PCs) for enhanced ROS generation; (3) high stability; (4) biocompatibility and minimal dark toxicity. [11][12][13] However, few M-PCs have reached clinical testing for PDT due to their poor solubility and tendency to aggregate in aqueous environments, which induces self-quenching of excited M-PCs and significantly reduces PDT efficacy. [14][15][16] Nanoscale metal-organic frameworks (nMOFs) have shown great potential in biomedical applications.…”