Profile of Adverse Drug Reactions in TB Patients Taking ATT

Asati, Aashutosh

doi:10.18535/jmscr/v4i12.48

Cited by 4 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spectrum of adverse effects were loss of appetite: 85.5%, dyspepsia: 62.4%, anorexia/nausea/vomiting: 42.9%; joint pain 5.7%; headache/fever: 5.1%, jaundice/hepatitis: 2%;dyspnoea 1.7%, severe weight loss and dermatological manifestation 1.2% each.Compared with most similar studies (7)(15)(16)(17)( 18) the incidence of the ADRs in this study was higher. Similarly, the spectra of adverse effects observed in our study are also different from those previously studied(7)(8)(17) (19). This may be attributed to study settings, patient's demographic variables, treatment phase, and treatment categories(2)(7)( 17) (20).…”

Section: Discussioncontrasting

confidence: 86%

“…About previous studies conducted in different localities, the patients' demographic variables including ethnicity, age, sex, nutritional status, social behaviors, pre-existing diseases or dysfunction had shown a signi cant association to the likely occurring ADRs in ATT medicated patients(2)(8)(15)(16)(17) (19). Likewise, in our multivariate logistic analysis: female, abnormal BMI, patients' behaviors i.e.…”

Section: Discussionsupporting

confidence: 65%

See 1 more Smart Citation

Spectrum of Adverse Effects and it’s Associations in Patient Medicated with Anti-Tubercular Drugs

Khadka¹,

Rai²,

Khadga³

2021

Preprint

View full text Add to dashboard Cite

BackgroundEvidence suggests that adverse drug effects (ADRs) from long-term therapeutic intervention in tuberculosis are obvious; however, were taken insouciantly due to the only therapeutic alternative. Hence, this study was undertaken to characterize the adverse effects and its association among patients medicated with anti-tubercular drugs.MethodsA longitudinal prospective study was conducted among the patient medicated with anti-tubercular drugs. As per the guideline of Nepal’s National tuberculosis control program (NTP);the treatment category was selected, fixed-dose-regimen was calculated, and the treatment outcome was affirmed. Patients’ demographics and other clinical details were extracted from the repository files and via a pre-tested questionnaire. Upon a consecutive follow-up, observed adverse effects were noted and multivariate logistic analysis against independent factors was done for elucidating any association.ResultsOf 177 cases enrolled, 138(77.9%) reported at least two adverse effects. In our multivariate logistic analysis: female, abnormal body mass index (BMI) i.e. underweight and overweight cases, patients’ behaviors i.e. smoking/drinking or both, clinically diagnosed cases, and intensive treatment phase were independently associated with adverse side effects. Loss of appetite (85.4%) was the commonest while dermatologic manifestations (1.2%) and severe weight-loss (1.2%) were the least observed side-effects among the patient medicated with anti-tubercular drugs.ConclusionsAdverse effects of anti-tubercular therapy are associated with patients’ demographics variables, study settings, treatment phase, and treatment categories. For the clinical management, the symptomatic treatment, regular follow-up after implicated therapy, and temporary therapeutic-discontinuation may be required.

show abstract

Section: Discussioncontrasting

confidence: 86%

Section: Discussionsupporting

confidence: 65%

Spectrum of Adverse Effects and it’s Associations in Patient Medicated with Anti-Tubercular Drugs

Khadka¹,

Rai²,

Khadga³

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…No adverse reactions were found among 8% of the patients. 22 A study by Nishant et al also reported gastrointestinal intolerance, arthralgia and itching with or without rashes as the most common ADRs. 23 When we compared the daily regimen ADRs with the intermittent regimen used for treating tuberculosis, it was seen that in intermittent regimen group there were 25.58% adverse reactions whereas our study on daily regimen ADRs were that of 35%.…”

Section: Discussionmentioning

confidence: 97%

Adverse drug reactions among new sputum positive pulmonary tuberculosis patients on daily treatment regimen: a prospective study from Haryana, India

Manjula

Majra

2021

Int J Community Med Public Health

View full text Add to dashboard Cite

Background: Daily regimen anti-tuberculosis treatment was adopted by Revised National Tuberculosis Control Programme (RNTCP) as a step to achieve tuberculosis elimination by 2025 in India. The change was implemented prior to completion of pilot study, which necessitated this study to note the self-reported Adverse Drug Reactions (ADRs).Methods: A prospective study with concurrent sampling design was carried on from June 2018 to June 2020 in the state of Haryana, India. Pre-tested semi-structured schedule was used to collect data based on RNTCP outcome definitions through two monthly (four visits) home visits. Mean±standard deviation, percentage, proportion and chi-square test was used. The p-value of <0.05 was considered as statistically significant.Results: Amongst 122 study participants 74 (60.7%) were males and 48 (39.3%) were females with mean age of 39.4±18.9 years. Majority were urban residents 87 (71.3%) and 35 (28.7%) rural residents. There were 25 (20.5%) tobacco smokers, nine (7.4%) alcohol consumers, and three (2.5%) smokeless tobacco users. Forty-five participants had ADRs and 54 ADR events had occurred, but none required change in treatment regimen. Sixteen (13.1%) reported loss of appetite followed by 10 (8.2%), flu-like symptoms, eight (6.6%) nausea, seven (5.7%) pain in joints, three (2.5%) abdomen pain, three (2.5%) headache, two (1.6%) itching and rash, one (0.8%) burning in hands and feet and one (0.8%) giddiness. Daily regimen ADR cases (36.9%) and events (44.3%) when comparatively higher than intermittent regimen (25.6%).Conclusions: The ADRs cases and events had occurred in higher proportion but were mild and hence did not require any regimen change.

show abstract

“…Malnutrition and hypovitaminosis are the major predisposing factor of TB [3] . Most common side effect of the antitubercular therapy is hepatotoxicity [4] . It has been reported that the fat soluble hypovitaminosis of S-25(OH)D in TB patients leads to low immunity which makes the patient vulnerable to TB.…”

mentioning

confidence: 99%

Vitamin D status among Pulmonary Tuberculosis Drug Induced Hepatotoxicity of Anti-tubercular Therapy

Parasher¹

2017

jmscr

View full text Add to dashboard Cite

Profile of Adverse Drug Reactions in TB Patients Taking ATT

Cited by 4 publications

References 4 publications

Spectrum of Adverse Effects and it’s Associations in Patient Medicated with Anti-Tubercular Drugs

Spectrum of Adverse Effects and it’s Associations in Patient Medicated with Anti-Tubercular Drugs

Adverse drug reactions among new sputum positive pulmonary tuberculosis patients on daily treatment regimen: a prospective study from Haryana, India

Vitamin D status among Pulmonary Tuberculosis Drug Induced Hepatotoxicity of Anti-tubercular Therapy

Contact Info

Product

Resources

About