Abstract:C A, Cavalcanti I L -Profilaxia da fibrilação atrial no pós-operatório imediato de cirurgia coronária: comparação entre propranolol e sotalol utilizados em baixas doses. RESUMO: Objetivo: Comparar a eficácia de dois protocolos terapêuticos usando baixas doses de betabloqueadores para prevenção de fibrilação atrial no pós-operatório imediato de cirurgia coronária.Métodos: 154 pacientes, submetidos à cirurgia coronária, foram randomizados em dois grupos: no grupo I (n = 72), os doentes receberam Sotalol (80 mg/d… Show more
“…A randomized study of 253 patients showed a reduction in the incidence of AF with both drugs (sotalol being more effective) however the pro-arrhythmogenic effect of these drugs remains uncertain [13]. In another study, Wanderley et al [14], comparing the use of low-dose propranolol and sotalol in the postoperative period of CABG and obtained an overall incidence of AF of 7.1% which was lower in the group taking sotalol but without significant statistical difference. Ventral cardiac denervation, described by Arnulff in 1936, was widely employed in the prevention of coronary artery spasms in the 1970s.…”
Objective: To evaluate the effect of ventral cardiac denervation on the incidence of atrial fibrillation after coronary artery bypass grafting.Methods: Between September and November 2005, 50 patients from the same institution, without previous diagnosis of atrial arrhythmia, presenting with coronary heart disease with indication for coronary artery bypass grafting were enrolled in a prospective, randomized study. The exclusion criteria were: patients older than 75 years of age, previous history of atrial arrhythmia and associated heart surgeries. Denervation was performed before cardiopulmonary bypass by removing the adipose tissues around the superior vena cava, aorta and pulmonary artery. Patients submitted to denervation were compared with a control group regarding demographic, clinical and operative variables.
“…A randomized study of 253 patients showed a reduction in the incidence of AF with both drugs (sotalol being more effective) however the pro-arrhythmogenic effect of these drugs remains uncertain [13]. In another study, Wanderley et al [14], comparing the use of low-dose propranolol and sotalol in the postoperative period of CABG and obtained an overall incidence of AF of 7.1% which was lower in the group taking sotalol but without significant statistical difference. Ventral cardiac denervation, described by Arnulff in 1936, was widely employed in the prevention of coronary artery spasms in the 1970s.…”
Objective: To evaluate the effect of ventral cardiac denervation on the incidence of atrial fibrillation after coronary artery bypass grafting.Methods: Between September and November 2005, 50 patients from the same institution, without previous diagnosis of atrial arrhythmia, presenting with coronary heart disease with indication for coronary artery bypass grafting were enrolled in a prospective, randomized study. The exclusion criteria were: patients older than 75 years of age, previous history of atrial arrhythmia and associated heart surgeries. Denervation was performed before cardiopulmonary bypass by removing the adipose tissues around the superior vena cava, aorta and pulmonary artery. Patients submitted to denervation were compared with a control group regarding demographic, clinical and operative variables.
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