Profil et sensibilité aux antibiotiques de 1879 bactéries urinaires pathogènes isolées chez l’enfant (2012–2013)

Marzouk, Manel; Ferjani, Asma; Ali, Mahboob; Boukadida, Jalel

doi:10.1016/j.arcped.2015.02.015

Cited by 12 publications

(1 citation statement)

References 14 publications

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“…Syndromic infections are often treated with third-generation cephalosporins, and high levels of resistance to these antimicrobials are worrisome. 35 , 36 MDR ESBL-producing bacteria were found to be generally resistant to ampicillin, third-generation cephalosporins, and fluoroquinolones. Several studies conducted in Ghana 16 , 37 and elsewhere have reported this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Laboratory-based nationwide surveillance of antimicrobial resistance in Ghana

Opintan

Newman

Arhin

et al. 2015

IDR

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Global efforts are underway to combat antimicrobial resistance (AMR). A key target in this intervention is surveillance for local and national action. Data on AMR in Ghana are limited, and monitoring of AMR is nonexistent. We sought to generate baseline data on AMR, and to assess the readiness of Ghana in laboratory-based surveillance. Biomedical scientists in laboratories across Ghana with capacity to perform bacteriological culture were selected and trained. In-house standard operating protocols were used to perform microbiological investigations on clinical specimens. Additional microbiological tests and data analyses were performed at a centralized laboratory. Surveillance data were stored and analyzed using WHONET program files. A total of 24 laboratories participated in the training, and 1,598 data sets were included in the final analysis. A majority of the bacterial species were isolated from outpatients (963 isolates; 60.3%). Urine (617 isolates; 38.6%) was the most common clinical specimen cultured, compared to blood (100 isolates; 6.3%). Ten of 18 laboratories performed blood culture. Bacteria isolated included Escherichia coli (27.5%), Pseudomonas spp. (14.0%), Staphylococcus aureus (11.5%), Streptococcus spp. (2.3%), and Salmonella enterica serovar Typhi (0.6%). Most of the isolates were multidrug-resistant, and over 80% of them were extended-spectrum beta-lactamases-producing. Minimum inhibitory concentration levels at 50% and at 90% for ciprofloxacin, ceftriaxone, and amikacin on selected multidrug-resistant bacteria species ranged between 2 µg/mL and >256 µg/mL. A range of clinical bacterial isolates were resistant to important commonly used antimicrobials in the country, necessitating an effective surveillance to continuously monitor AMR in Ghana. With local and international support, Ghana can participate in global AMR surveillance.

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