Development of carboxymethyl cellulose-based hydrogel and nanosilver composite as antimicrobial agents for UTI pathogens

Alshehri, Saad M.; Aldalbahi, Ali; Al-hajji, Abdullah Baker; Chaudhary, Anis Ahmad; Panhuis, Marc in het; Alhokbany, Norah; Ahamad, Tansir

doi:10.1016/j.carbpol.2015.11.004

Cited by 78 publications

(38 citation statements)

References 46 publications

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“…There are several anti-fouling catheters including those coated with hydrogels (most popular) [27,28], poly(tetrafluoroethylene) [34][35][36][37][38], polyzwitterions [39][40][41], and poly(ethylene glycol) [42][43][44][45][46]. Furthermore, surface topography modification [47][48][49][50] and enzymes-immobilized coatings [51][52][53][54][55][56][57][58] have been explored for prevention of microbial colonization and biofilm formation. These polymers and modifications are discussed in detail in this section.…”

Section: Approaches To Restriction Of Cauti By Inhibition Of Microbiamentioning

confidence: 99%

“…Silver ions are the most popular clinically tested and available coating for urinary catheters yet the effectiveness of them is still debatable due to vast differences in outcomes in vitro, in animal models and in clinical trials studies [34,51,[72][73][74][75][76][77][78][79][80][81][82][83][84][85][86]. The mechanisms by which silver is toxic to bacteria include disruption of the membrane, proteins, and by inducing oxidative stress through the release of silver ions into the bladder [15].…”

Section: Silver Ionsmentioning

confidence: 99%

“…Nanoparticles have become popular as a drug delivery system since they improve bioavailability by enhancing solubility, stability, and biodistribution [88]. Nanoparticles have been used to deliver metals including silver [51,85,[89][90][91], gold [92], copper [93][94][95], and zinc [96]. These metal nanoparticles in the context of urinary catheters will be discussed below.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…However, inflammation and toxicity assessment would be more reliable in an animal model of CAUTI, since the bladder environment is different from a subcutaneous environment. Alshehri and collaborators showed that silver nanoparticles embedded in hydrogel coating were successful in inhibiting growth of E. coli, Klebsiella pneumoniae, P. aeruginosa, Proteus vulgaris, S. aureus, and P. mirabilis [51]. Despite these positive results, their overall antimicrobial efficiency compared to silver ions is still debated [89].…”

Section: Nanoparticlesmentioning

confidence: 99%

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Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections

Andersen

Flores-Mireles

2019

Coatings

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Urinary catheters are common medical devices, whose main function is to drain the bladder. Although they improve patients' quality of life, catheter placement predisposes the patient to develop a catheter-associated urinary tract infection (CAUTI). The catheter is used by pathogens as a platform for colonization and biofilm formation, leading to bacteriuria and increasing the risk of developing secondary bloodstream infections. In an effort to prevent microbial colonization, several catheter modifications have been made ranging from introduction of antimicrobial compounds to antifouling coatings. In this review, we discuss the effectiveness of different coatings in preventing catheter colonization in vitro and in vivo, the challenges in fighting CAUTIs, and novel approaches targeting host-catheter-microbe interactions.

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Section: Approaches To Restriction Of Cauti By Inhibition Of Microbiamentioning

confidence: 99%

Section: Silver Ionsmentioning

confidence: 99%

Section: Nanoparticlesmentioning

confidence: 99%

Section: Nanoparticlesmentioning

confidence: 99%

See 2 more Smart Citations

Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections

Andersen

Flores-Mireles

2019

Coatings

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“…The reduction of silver ions into nanosilver has led to the development of several commercial products . The reduction step in nanotechnology is very important.…”

Section: Future Perspectivesmentioning

confidence: 99%

Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems

Anjum¹,

Gupta²

2018

Global Challenges

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Functional designing of nanogels has become an attractive domain of biomedical engineering to develop bioactive materials with innovative features for the human healthcare system. Nanosilver has attracted enormous attention due to its wide antimicrobial spectrum and ability to kill almost all types of bacteria in its vicinity. However, the most crucial challenge for bioscientists is the lack of binding ability of nanosilver with the material surfaces that allow nanosilver to leach out to the surrounding tissue and exert toxicity while the biomaterial is in contact with the living system. Designing nanosilver within a nanogel confinement offers enormous possibilities to develop functional bioactive nanoparticles that may be bonded to any biomaterial surface via the nanogel functionality. This approach requires the proper combination of material science with nanotechnology and biotechnology to innovate interesting domain of functional nanogels with unique features. This work aims at providing a critical review on the current progress, approaches, and vision in designing nanosilver‐entrapped nanogel particles with diverse functionality, and their bioactivity against microorganisms for human healthcare devices.

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Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

Zhang

Wang

Wei

et al. 2023

Adv Healthcare Materials

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In the surgical treatment of urinary diseases, ureteral stents are commonly used interventional medical devices. Although polymer ureteral stents with polyurethane as the main constituent are widely used in the clinic, the need for secondary surgery to remove them and their propensity to cause bacterial infections greatly limit their effectiveness. To satisfy clinical requirements, an electrospinning‐based strategy to fabricate PLGA ureteral stents with silver@graphdiyne is innovated. Silver (Ag) nanoparticles are uniformly loaded on the surface of graphdiyne (GDY) flakes. It is found that the incorporation of Ag nanoparticles into GDY markedly increases their antibacterial properties. Subsequently, the synthesized and purified Ag@GDY is homogeneously blended with poly(lactic‐co‐glycolic acid) (PLGA) as an antimicrobial agent, and electrospinning along with high‐speed collectors is used to make tubular stents. The antibacterial effect of Ag@GDY and the porous microstructure of the stents can effectively prevent bacterial biofilm formation. Furthermore, the stents gradually decrease in toughness but increase in strength during the degradation process. The cellular and subcutaneous implantation experiments demonstrate the moderate biocompatibility of the stents. In summary, considering these performance characteristics and the technical feasibility of the approach taken, this study opens new possibilities for the design and application of biodegradable ureteral stents.

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Development of carboxymethyl cellulose-based hydrogel and nanosilver composite as antimicrobial agents for UTI pathogens

Cited by 78 publications

References 46 publications

Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections

Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections

Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems

Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

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