Profil des adénomes hypophysaires en Afrique subsaharienne à propos de 38 cas

Abodo, J.; Haïdara, Adéréhime; Dago, P. Koffi; Kouassi, F.; Hue, L.; Lokrou, A.

doi:10.1016/j.ando.2016.07.381

Cited by 4 publications

(6 citation statements)

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“…Of the 242 patients, the endocrine syndrome was dominated by gonadotropic disorders, mainly amenorrhea-galactorrhea syndrome. This corroborates data from the African literature [14]. Its impact on the fertility of the couple directs the patients initially in urology or gynecology according to the sex.…”

Section: Clinical Datasupporting

confidence: 89%

“…Beyond a few disparities, the average age of 42.4 years found in our cohort was similar to the data in the literature [13]. The gender profile varies from one study to another and according to the specialty of the authors [8] [12] [13] [14]. The female predominance can be explained by the preponderance of prolactin adenomas more expressive in women by amenorrhea-galactorrhea syndrome.…”

Section: Epidemiological Datasupporting

confidence: 86%

“…Worldwide, there is a disparity in the frequency of the two main etiologies of pituitary adenomas, namely prolactinomas and non-functional adenomas [3] [4] [8] [11] [14]. We report a predominance of non-functional adenomas (51.8%), followed by prolactinomas (32.78%).…”

Section: Clinical Datamentioning

confidence: 82%

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Profile of Pituitary Adenomas in Senegal: Epidemiological, Clinical and Therapeutic Aspects about 241 Collected Cases

Demba,

Mané,

Maguette

et al. 2023

OJIM

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Introduction: in adults, adenomas are the most frequent causes of pituitary tumours. The objective was to characterize its epidemiological and clinical aspects, as well as its therapeutic modalities in Senegal. Methodology: this was a multicenter, retrospective, descriptive and analytical study carried out from the Senegalese register of pituitary adenomas (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020)(2021)(2022). Results: 242 patients were collected with an average age of 42.4 ± 13 years and a sex ratio (M/F) of 0.91. The mean consultation time was 19.7 ± 23 months. The circumstances of discovery were pituitary apoplexy (11 cases, 4.54%), tumor syndrome (176 cases, 72.72%), gonadal manifestations (103 cases, 42.56%), dysmorphic syndrome (21 cases, 8.68%), hypercorticism (15 cases, 6.19%). Morphologically, it was a macroadenoma (197 cases, 81.40%), an extensive adenoma (22 cases, 9.10%). The hormonal profile was lactotropic hypersecretion (80 cases, 33.05%), somatotropic (13 cases, 5.39%), corticotropic (14 cases, 5.78%), mixed (9 cases, 3.71%). The factors significantly associated with prolactinoma were young age (p = 0.000), female sex (p = 0.000), long consultation delay (p = 0.000) and microadenoma (p = 0.001). Only arterial hypertension was associated with acromegaly (p = 0.000). We found a significant correlation between Cushing's disease and microadenomas (p = 0.000). Non-secreting adenomas were significantly associated with advanced age (p = 0.000), long delay in consultation (p = 0.000), male gender (p = 0.000), tumor syndrome (p = 0.001) and macroadenomas (p = 0.000). Pituitary surgery was effective in 173 patients (71.49%) including 166 cases (68.59%) by transphenoidal approach. Postoperative incidents were transient diabetes insipidus in

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Section: Clinical Datasupporting

confidence: 89%

Section: Epidemiological Datasupporting

confidence: 86%

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Profile of Pituitary Adenomas in Senegal: Epidemiological, Clinical and Therapeutic Aspects about 241 Collected Cases

Demba,

Mané,

Maguette

et al. 2023

OJIM

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“…The most common clinical manifestations of pituitary macroadenomas are endocrine and/or tumor disorders (headaches and loss of vision found in our patient) Margani et al [5] and N'diaye et al [16] also reported headaches and blurred vision. More rarely, when a macroadenoma grows towards the base of the skull, it can gradually erode the floor of the saddle and the sphenoid sinus, leading to leakage of cerebrospinal fluid (CSF) causing infection such as meningitis [22].…”

Section: Discussionsupporting

confidence: 64%

“…There are also mixed (association of two secreting hormone) pituitary adenomas described by some authors [9] [12] [16] [17] [18]. Unlike women, who typically have microadenomas, most men have macroadenomas, which would likely be related to delayed diagnosis although there may be sex-specific differences in the biological characteristics of tumors [13] [14].…”

Section: Discussionmentioning

confidence: 99%

Pituitary Adenoma Complicated by Acute Bacterial Meningitis in a Patient in Kara (Togo)

Djalogue,

Agba,

Mossi

et al. 2023

OJIM

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Introduction: In the context of pituitary adenoma, bacterial meningitis is a possible complication of surgical or medical treatment. The occurrence of meningitis before any treatment is exceptional, explained by the existence of an osteomeningeal breach caused by the adenoma whose main symptom is rhinorrhea. Case Report: We report a case of bacterial meningitis complicating a prolactin pituitary macroadenoma. The patient had been referred for jet vomiting in a febrile context preceded by headaches and visual blurring. There was no rhinorrhea. The examination revealed a meningeal syndrome and the diagnosis of acute bacterial meningitis was made. The isolated germ was the pneumococcus. Faced with headaches and visual blurring, a cerebral scan revealed a pituitary macroadenoma and pituitary hormone dosage had shown hyperprolactinemia. The meningitis was sterilized and the prolactinoma was treated with dopaminergic agonists. This allowed the normalization of prolactinemia and the disappearance of symptoms. Conclusion: The pituitary adenoma was complicated by bacterial meningitis without treatment and the presence of a meningeal breach. Hormonal and bacterial treatments have been successful.

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