Profil Asam Laktat Penderita Diabetes Mellitus Terkendali (Kontrol) Dan Tidak Terkendali (Kontrol)

Indrayanti, Laily; Mulyono, Harjo

doi:10.24293/ijcpml.v14i3.927

“…Lactic acid (lactic acid/lactate) is a carbohydrate metabolism intermediate (intermediate product) generated mainly by white skeletal muscle, the interior of the kidney (renal medulla), the brain, skin, and erythrocytes ( 21 ). This is a rare metformin adverse effect.…”

Section: Resultsmentioning

confidence: 99%

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease

Rahman¹,

Tuba²

2022

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Background: Diabetes Mellitus is a metabolite disorder with parameters of high blood sugar levels. In the management of diabetes can be used the drug metformin is the gold of choice to achieve a therapeutic effect and rarely causes side effects of the drug, but it still has debate view. However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis. Objective: This study aims to evaluate the side effect of Metformin for diabetic kidney diseases (DKD) patients. Method: This study used the Narrative Review Method that was obtained from 2011 to 2021, in the English language from PubMed, Google Scholar, and Cochrane Library. Results: Metformin is at the forefront of the treatment of type 2 diabetes mellitus (DM2). Metformin is likely to have lactic acidosis-related adverse effects in chronic kidney disease (CKD) patients, such as increased arterial lactate. Lactic acidosis is defined as an increase in arterial lactate with an indicator of more than five mmol/L and an arterial blood pH of less than 7.35. Metformin-induced lactate levels are considered to be below the parameters. DKD risk factors can be conceptually classified as several susceptibility factors, initiation factors, and developmental factors. The two most prominent risk factors are hyperglycemia and hypertension. Conclusion: Metformin can increase lactate levels in CKD patients but is still below the parameters of lactic acidosis. This study may have some weaknesses and requires further prospective research to validate the results.

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Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

Rahman¹,

Tuba²

2022

Preprint

0

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Background: Diabetes Mellitus is a metabolite disorder with parameters of high blood sugar levels. In the management of diabetes can be used the drug metformin is the gold of choice to achieve a therapeutic effect and rarely causes side effects of the drug, but it still has debate view. However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis. Objective: This study aims to evaluate the side effect of Metformin for diabetic kidney diseases (DKD) patients. Method: This study used the Narrative Review Method that was obtained from 2011 to 2021, in the English language from PubMed, Google Scholar, and Cochrane Library. Results: Metformin is at the forefront of the treatment of type 2 diabetes mellitus (DM2). Metformin is likely to have lactic acidosis-related adverse effects in chronic kidney disease (CKD) patients, such as increased arterial lactate. Lactic acidosis is defined as an increase in arterial lactate with an indicator of more than five mmol/L and an arterial blood pH of less than 7.35. Metformin-induced lactate levels are considered to be below the parameters. DKD risk factors can be conceptually classified as several susceptibility factors, initiation factors, and developmental factors. The two most prominent risk factors are hyperglycemia and hypertension. Conclusion: Metformin can increase lactate levels in CKD patients but is still below the parameters of lactic acidosis. This study may have some weaknesses and requires further prospective research to validate the results.

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The Relationship between HbA1c and Glucosuria in Diabetes Mellitus (DM) Patients

Nurjanah,

Wijaya,

Meri

et al. 2023

medicra

0

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Diabetes mellitus is a condition of abnormalities in blood glucose metabolism that can cause various macroangiopathy complications such as disorders of the peripheral blood vessels, heart blood vessels, cerebral blood vessels as well as microangipathic complications such as diabetic retinopathy disorders, nephropathy and neuropathy. HbA1c describes the level of sugar in the blood for the last 3 months. Glucose is not found in normal urine because it is reabsorbed back into the blood vessels by renal filtration. The aim of this study was to determine the relationship between HbA1c levels and glucosuria in people with diabetes mellitus. The design of this study is a cross-sectional approach to DM patients. The sampling technique used was purposive sampling. Data analysis was carried out by means of Spearman's rank correlation test. Results Correlation analysis showed that there was a significant relationship between HbA1c levels and glucosuria in DM patients p-value 0.005 with a coefficient value of 0.597. The conclusion from this study is that there is a significant relationship with a strong correlation strength and a positive correlation direction for DM sufferers.

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Profil Asam Laktat Penderita Diabetes Mellitus Terkendali (Kontrol) Dan Tidak Terkendali (Kontrol)

Cited by 3 publications

References 3 publications

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

The Relationship between HbA1c and Glucosuria in Diabetes Mellitus (DM) Patients

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