Products of cells cultured from gliomas. IV. Extracellular matrix proteins of gliomas

McKeever, Paul E.; Fligiel, Suzanne E. G.; Varani, James; Hudson, Jack W.; Smith, David C.; Castle, Roy; McCoy, J. Philip

doi:10.1002/ijc.2910370612

Cited by 44 publications

(31 citation statements)

References 31 publications

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“…A FN (FN) é uma glicoproteína adesiva (vide introdução), e a sua produção por células de glioma remonta ao final da década de 1970 e início de 1980 quando Mckeever et al (1986), Halfter et al (1989), entre outros, evidenciaram que células C6, cultivos primários de gliomas e astrócitos normais eram capazes de produzi-la. Schachner et al (1978) mostraram a presença de FN na junção gliomesenquimal de tumores, mas não em neurônios, em células da glia normais e em tumores gliais.…”

Section: Glicoproteínas Adesivas Fn E Vnunclassified

“…(GBMs e Astrocitomas anaplásicos) expressam isoformas de FN que contêm essas duas seqüências (MCKEEVER et al, 1986;HALFTER et al, 1989;SCHACHNER et al, 1978;OHNISHI et al, 1998;OHNISHI et al 1997;CHINTALA et al, 1996a AMBERGER et al, 1998;GLADSON et al, 1995).…”

Section: Três Diferentes Regiões Do Rnam (Ed-a Ed-b E Iiics) As Regunclassified

“…Esses diferentes sítios de dispersão conduzem à existência de GBMs multifocais, por outro lado os gliomas raramente realizam metástases fora do SNC. Uma provável explicação para esse fato é que as leptomeninges poderiam constituir uma barreira à dispersão celular INTRODUÇÃO (PEDERSEN et al, 1994 (GLADSON, 1999;BELOT et al, 2001;BELLAIL et al, 2004 (RUTKA et al, 1988;MCKEEVER et al, 1986;ALITALO et al, 1983;RABSON et al, 1977;NEDERMAN et al, 1984). "trilhos", para a sua migração (KNOTT et al, 1998;PAULUS e TONN, 1994;GOLDBRUNNER, 1998;GIESE et al, 1994;PAULUS et al, 1988).…”

Section: Introductionunclassified

“…A observação da produção de FN por células de glioma remonta ao final da década de 1970 e ao início de 1980 quando Mckeever et al (1986), Halfter et al (1989), entre outros, evidenciaram que células C6 de glioma de rato, cultivos primários de gliomas humanos e astrócitos normais eram capazes de produzi-la in vitro. Anos depois, Chintala et al (1996) e outros grupos de pesquisas mostraram que a FN, bem como a LN e o colágeno IV, estavam associadas à matrizes extracelulares e às células tumorais de GBMs (MCKEEVER et al, 1986;HALFTER et al, 1989;CHINTALA et al, 1996a;PLANCHENAULT et al, 2001;BOUTERFA et al, 1999 HALFTER et al, 1989).…”

Section: Introductionunclassified

“…Anos depois, Chintala et al (1996) e outros grupos de pesquisas mostraram que a FN, bem como a LN e o colágeno IV, estavam associadas à matrizes extracelulares e às células tumorais de GBMs (MCKEEVER et al, 1986;HALFTER et al, 1989;CHINTALA et al, 1996a;PLANCHENAULT et al, 2001;BOUTERFA et al, 1999 HALFTER et al, 1989).…”

Section: Introductionunclassified

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Análise comparativa das distribuições espaciais de moléculas envolvidas na migração e invasão de um tumor cerebral de rato in vivo.

Ramos¹

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Section: Glicoproteínas Adesivas Fn E Vnunclassified

Section: Três Diferentes Regiões Do Rnam (Ed-a Ed-b E Iiics) As Regunclassified

Section: Introductionunclassified

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Análise comparativa das distribuições espaciais de moléculas envolvidas na migração e invasão de um tumor cerebral de rato in vivo.

Ramos¹

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Astrocytoma cell interaction with elastin substrates: Implications for astrocytoma invasive potential

Jung¹,

Hinek²,

Tsugu³

et al. 1999

Glia

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Elastin has been identified within the meninges and the microvasculature of the normal human brain. However, the role that elastin plays in either facilitating astrocytoma cell attachment to these structures or modulating astrocytoma invasion has not been previously characterized. We have recently shown that astrocytoma cell lines and specimens produce tropoelastin, and express the 67 kDa elastin binding protein (EBP*). In the present report, we have established that astrocytoma cells attach to elastin as a substrate in vitro. The U87 MG astrocytoma cell line demonstrated the greatest degree of adhesion. In addition, all astrocytoma cell lines examined were capable of penetrating and migrating through an intact elastin membrane, and of degrading tritiated‐elastin, a process that could be prevented by the pre‐incubation of astrocytoma cells with EDTA, but not with α1‐antitrypsin. Astrocytoma cells were also capable of penetrating 1 mm sections of human brain tissue maintained as organotypic cultures. Interestingly, the invasive potential of cultured astrocytoma cells plated on organotypic cultures of human brain was significantly increased after exposure to elastin degradation products (κ‐elastin), which interact with astrocytoma cell surface EBP. Our data show that astrocytoma cells express a functional 67 kDa EBP, enabling them to potentially recognize and attach to elastin as a substrate. These data also suggest that this elastin receptor may be involved in processes which regulate regional astrocytoma invasion. GLIA 25:179–189, 1999. © 1999 Wiley‐Liss, Inc.

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Tumor type‐specific differences in cell‐substrate adhesion among human tumor cell lines

Varani

McKeever

Dixit

et al. 1987

Intl Journal of Cancer

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Cell lines derived from human tumors of 4 different histological types (squamous carcinomas, melanomas, gliomas and a fibrosarcoma) were examined for cell-substrate adhesion on plastic culture dishes and dishes coated with 50 micrograms of type-IV collagen. In the absence of exogenous adhesion factors, the squamous carcinoma cells attached and spread more rapidly than the other cells on both substrates. Once attached, the squamous carcinoma cells were also more difficult than the other cells to remove with proteolytic enzymes/EDTA. While the cell lines derived from melanomas, gliomas and the fibrosarcoma were less adhesive than the squamous carcinoma lines in the absence of exogenous adhesion factors, these cells were highly responsive to laminin. In contrast, laminin only slightly enhanced the attachment and spreading of squamous carcinoma cells on the plastic dishes and actually inhibited attachment and spreading on the collagen-coated dishes. These results indicate that there are tumor-type-specific differences in adhesiveness among human tumor cell lines and that cells from different tumor types may have distinct mechanisms for carrying out one of the functions critical to invasion.

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Products of cells cultured from gliomas. IV. Extracellular matrix proteins of gliomas

Cited by 44 publications

References 31 publications

Análise comparativa das distribuições espaciais de moléculas envolvidas na migração e invasão de um tumor cerebral de rato in vivo.

Análise comparativa das distribuições espaciais de moléculas envolvidas na migração e invasão de um tumor cerebral de rato in vivo.

Astrocytoma cell interaction with elastin substrates: Implications for astrocytoma invasive potential

Tumor type‐specific differences in cell‐substrate adhesion among human tumor cell lines

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