Products based on olive oil, betaine, and xylitol in the post-radiotherapy xerostomia

Martín, Marta; Marín, Alicia C; López, Miguel Serrano; Liñan, O.; Alvarenga, Felipe; Büchser, D.; Cerezo, Laura

doi:10.1016/j.rpor.2016.09.008

Cited by 15 publications

(13 citation statements)

References 14 publications

(12 reference statements)

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“…Routine excision of the submandibular gland during level I dissection causes a significant decrease in unstimulated saliva production, leading to xerostomia 6 . Another cause of xerostomia is adjuvant radiotherapy, and it may not be possible to spare the submandibular glands from radiotherapy fields in advanced stage diseases 7 . However, as the submandibular gland does not contain intraglandular lymph nodes, removal of an uninvolved submandibular gland may not always be necessary, particularly in cases of early stage oral cavity SCC, with the potential benefit of reducing post-operative xerostomia 1 .…”

Section: Introductionmentioning

confidence: 99%

Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

et al. 2018

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“…These results are similar to the ones reported from previous reports ( 15 , 27 , 28 ) where a 1% malic acid spray was shown to significantly increase unstimulated and stimulated salivary flow rates after two weeks of use. Similar to this, betaine containing mouthwashes ( 29 , 30 ) have also shown to increase non-stimulated salivary flow rates, although this is likely to be due to the xylitol present in betaine-based mouthwashes rather than from the betaine itself ( 29 ).…”

Section: Discussionmentioning

confidence: 63%

Interventions for the treatment of xerostomia: A randomized controlled clinical trial

et al. 2021

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Background Xerostomia or dry mouth sensation corresponds to a common clinical problem that can significantly impair the oral health related quality of life (OHRQoL). Currently, there is a large variety of local agents available for the treatment of xerostomia, but there is a lack robust evidence supporting the use of one treatment over another. We aimed to compare the effectiveness of a 1% malic acid salivary stimulant spray with a 1.33% betaine-based saliva substitute mouthwash in the improvement of xerostomia. Material and Methods Fifty-one participants with drug induced or idiopathic xerostomia were randomly allocated into three groups, two intervention and one control group (placebo). OHRQoL and severity of xerostomia were assessed with the OHIP-14sp questionnaire and a visual analogue scale (VAS) respectively. Stimulated and non-stimulated salivary flow rates before and after treatments were also measured. Results All three groups reported a significantly improvement in the dry mouth sensation and non-stimulated salivary flow rates, but only the malic acid spray and the betaine-based mouthwash significantly improved the OHRQoL. There were no significant differences between both intervention groups. Conclusions This study provides evidence that both tested agents are comparable in improving the dry mouth sensation and OHRQoL of patients with drug induced and idiopathic xerostomia. Key words: Xerostomia, dry mouth, malic acid, betaine, oral-health related quality of life.

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“…The greater improvement of dry mouth in the test group could be due to the properties of ingredients like betaine, allantoin, olive oil and provitamine B5 present in Xerostom ® products and the absence of sodium lauryl sulphate. Previous available studies (Martín et al, ; Ship et al, ) about the use of Xerostom ® in population groups with polypharmacy‐induced and radiation‐induced xerostomia obtained a significant decrease in VAS after the use of these products. These studies showed that these topical products are safe and well tolerated.…”

Section: Discussionmentioning

confidence: 90%

“…Previous studies reported that the daily use of topical dry mouth products containing olive oil, betaine, provitamine B5, allantoin, parsley oil and xylitol (Xerostom ® ) is safe and effective in relieving symptoms of xerostomia in a population with polypharmacy‐induced xerostomia (Ship, McCutcheon, Spivakovsky, & Kerr, ), radiation‐induced hyposalivation (Martín et al, ; Martín‐Martín, López, & Cerezo, ) and subjects with dry mouth symptoms (Lapiedra, Gómez, Sánchez, Pereda, & Turner, ). Xerostom ® products have different beneficial active components and do not contain sodium lauryl sulphate.…”

Section: Introductionmentioning

confidence: 99%

Effects of Xerostom^® products on xerostomia in primary Sjögren’s syndrome: A randomized clinical trial

et al. 2019

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Objectives To assess the effects of Xerostom® toothpaste and mouthwash in primary Sjögren's syndrome (pSS) patients with xerostomia. Subjects and Methods A double‐blinded, randomized study where patients were assigned at baseline test or control products. Patients used the products 3 times/day/28 days. We used a visual analogue scale (VAS) for xerostomia and an Oral Health Impact Profile‐14 (OHIP‐14), baseline and after treatment, to assess possible improvement. Results A total of 28 patients with pSS were included in this study, but only 24 finished it (all women, mean age 55.21 ± 11.87), and 13 patients received the test and 11 the control. VAS and OHIP‐14 scores decreased in both groups after treatment but significant differences between groups were not found. We do not detect VAS intragroup significant differences before and after treatment in test and control groups. A significant improvement in OHIP‐14 was identified in the treatment group, while no significant differences were observed in the control group. No adverse effects were present. Conclusions Xerostom® toothpaste and mouthrinse may alleviate and improve quality of life without associated side effects, but further research with a larger number of participants and follow‐up are necessary to establish the positive efficacy of these topical products in pSS patients.

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Products based on olive oil, betaine, and xylitol in the post-radiotherapy xerostomia

Cited by 15 publications

References 14 publications

Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

Interventions for the treatment of xerostomia: A randomized controlled clinical trial

Effects of Xerostom^® products on xerostomia in primary Sjögren’s syndrome: A randomized clinical trial

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Products based on olive oil, betaine, and xylitol in the post-radiotherapy xerostomia

Cited by 15 publications

References 14 publications

Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

Interventions for the treatment of xerostomia: A randomized controlled clinical trial

Effects of Xerostom® products on xerostomia in primary Sjögren’s syndrome: A randomized clinical trial

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Effects of Xerostom^® products on xerostomia in primary Sjögren’s syndrome: A randomized clinical trial