Production, properties, and applications of solid self-emulsifying delivery systems (S-SEDS) in the food and pharmaceutical industries

Gonçalves, Antónia; Nikmaram, Nooshin; Roohinejad, Shahin; Estevinho, Berta N.; Rocha, Fernando; Greiner, Ralf; McClements, David Julian

doi:10.1016/j.colsurfa.2017.10.076

Cited by 76 publications

(42 citation statements)

References 200 publications

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“…Use of μEs for the preparation of NDs is still in its early stages . In this study, we have made an effort to use biocompatible μE for devising fluoroquinolone loaded formulation, which has been useful for the NPs formation and has improved drug dissolution profile and stability when compared to the conventional formulation.…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

et al. 2018

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Microemulsions (μEs) are being exploited as a potential route for yielding an extensive range of nanoparticles of different chemical nature, shapes and sizes. Nanodrugs offer new avenues for structuring better “drug delivery systems”. In this study, an oil‐in‐water (o/w) μE formulation comprising N‐butyl acetate/polysorbate 80/ethanol/water was developed for the preparation of nanoparticles of fluoroquinolone antibiotics (FLQ‐NPs). A pseudoternary phase diagram was mapped at constant surfactant/cosurfactant (1:2), revealing improved and high loading of FLQs in an optimum μE formulation. The as‐formulated μE showed high loading of FLQs as; levofloxacin (4.20 wt.%), ciprofloxacin (3.16 wt.%), moxifloxacin (2.53 wt.%), gatifloxacin (1.36 wt.%), ofloxacin (0.70 wt.%). Fourier transform IR analysis indicated good compatibility of each FLQ drug with μE excipients. However, dynamic light scattering showed an increase in the average particle size of the μE on drug loading, indicating the accumulation of FLQ at interface layer of the micelle. Additionally, lyophilized levofloxacin (a selected antibiotic) showed long‐term stability, amorphous morphology and improved dissolution rate, inspected by scanning transmission electron microscopy, X‐ray diffraction and electronic spectroscopy, respectively. Moreover, fluorescence measurements suggested the interfacial vicinity of levofloxacin within the μE domain, which may support controlled release of drug during systemic circulation.

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Section: Introductionmentioning

confidence: 99%

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

et al. 2018

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“…Los S-SEDDS combinan las ventajas de los SEDDS, es decir, solubilidad y biodisponibilidad mejorada con las ventajas de las formas de dosificación sólidas [68], como lo son, mejor estabilidad, costos de producción relativamente bajos [119], facilidad en el manejo y almacenamiento, dosificación más precisa [18], y mejor control en el proceso de producción [8]. Entre las técnicas más utilizadas de solidificación de SEDDS se encuentran: secado por atomización [124], granulación por fusión [125], extrusión por esferonización [55] y adsorción a carriers sólidos [126,127], entre otras.…”

Section: Sistemas Autoemulsificables Sólidosunclassified

“…• Secado por atomización: es una técnica excelente para la rápida remoción del solvente de un sistema [124]. Es ampliamente usada en la industria farmacéutica, la mayoría de producción de polvos se realiza mediante esta técnica [126]. Básicamente, consiste en la preparación de una formulación al mezclar los excipientes del sistema junto con un carrier sólido y la solubilización de dicha mezcla previa al secado [8].…”

Section: Sistemas Autoemulsificables Sólidosunclassified

“…• Entre las ventajas de esta técnica se encuentran: un rápido y continuo secado en un solo paso, bajos costos de operación, capacidad de encapsular compuestos sensibles a la temperatura y la generación de partículas de tamaño reducido y uniforme [126]. Una posible desventaja en la utilización de esta técnica radica en la pérdida del principio activo a través de la corriente de aire caliente debido a una ineficiente adsorción en el carrier.…”

Section: Sistemas Autoemulsificables Sólidosunclassified

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Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

Cueto

Ortega

Sotomayor

2019

Rev. Colomb. Cienc. Quím. Farm.

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Los grandes avances tecnológicos en la industria farmacéutica, que involucran el uso de la química combinatoria y el cribado de alto rendimiento, han conllevado al descubrimiento de muchas entidades químicas candidatas a fármacos que presentan baja solubilidad acuosa, debido a su elevada complejidad molecular, lo que hace difícil el desarrollo de productos con estas sustancias. Los sistemas de entrega de fármacos autoemulsificables (SEDDS) han generado un interés para el desarrollo farmacéutico porque son una alternativa efectiva para mejorar la biodisponibilidad de fármacos poco solubles en agua. Para describir el estado de conocimiento sobre estos sistemas se realizó una revisión sistemática en diferentes bases de datos sobre la literatura relacionada con los SEDDS a nivel nacional e internacional, logrando así describir los aspectos más relevantes sobre los SEDDS (tipos, composición, mecanismos para aumentar biodisponibilidad, caracterización, formulaciones). A pesar de las numerosas investigaciones realizadas durante los últimos años que muestran el potencial de los SEDDS para mejorar la biodisponibilidad de los fármacos poco solubles en agua, se pudo evidenciar que solo algunas sustancias activas han sido incluidas en estos sistemas y comercializadas exitosamente, esto debido a algunas limitaciones que indican la necesidad de un mayor entendimiento sobre estos sistemas.

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“…Nowadays, there is great interest in the development of functional foods and beverages containing lipophilic bioactive agents that exhibit health benefits, such as oil‐soluble vitamins and nutraceuticals. Microencapsulation has been utilized as a technique for the fortification and controlled release of functional food components such as antioxidants, flavors, fatty acids, vitamins, minerals, and so on (Estevinho and others ; Aguiar and others ; Gonçalves and others , ). A number of microencapsulation techniques for bioactive compounds such as functional edible oils are applied which can be generally divided into 2 separate categories physical (for example, spray‐drying) and chemical (for example, complex coacervation) techniques (Roohinejad and others , ; Gharibzahedi and Jafari , , ; Nikmaram and others ).…”

Section: Introductionmentioning

confidence: 99%

New Trends in the Microencapsulation of Functional Fatty Acid‐Rich Oils Using Transglutaminase Catalyzed Crosslinking

Gharibzahedi

George

Greiner

et al. 2018

Comp Rev Food Sci Food Safe

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Preparing stable protein-based microcapsules containing functional fatty acids and oils for food applications has been a big challenge. However, recent advances with transglutaminase (TGase) enzyme as an effective protein cross-linker could provide workable solutions for the encapsulation of omega-3 and omega-6 fatty acids without compromising their targeted release and their biological and physicochemical characteristics. The recent and available literature related to the microencapsulation techniques, physical and oxidative properties, and core retention and release mechanisms of TGasecrosslinked microcapsules entrapping edible oils were reviewed. The effects of factors involved in microencapsulation processes, on the efficiency and quality of the produced innovative microcapsules were also discussed and highlighted. A brief focus has been finally addressed to new insights and additional knowledge on micro-and nanoencapsulation of lipophilic food-grade ingredients by TGase-induced gelation. Two dominant microencapsulation methods for fish, vegetable, and essential oils by TGase-crosslinking are complex coacervation and emulsion-based spray drying. The developed spherical particles (<100 μm) with some wrinkles and smooth surfaces showed an excellent encapsulation efficiency and yield. A negligible release rate and a substantial retention level can result for different lipid-based cores covered by TGase-crosslinked proteins during the oral digestion and storage. A significant structural, thermal and oxidative stability for edible oils-loaded microcapsules in the presence of TGase can be also obtained.

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Production, properties, and applications of solid self-emulsifying delivery systems (S-SEDS) in the food and pharmaceutical industries

Cited by 76 publications

References 200 publications

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

New Trends in the Microencapsulation of Functional Fatty Acid‐Rich Oils Using Transglutaminase Catalyzed Crosslinking

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