Production of Uniform Microspheres

Abstract

A new technique has been developed for producing microspheres uniform in volume and fluorescence or radioactive tracer. Very uniform spheres with selected diameters are produced by introducing one liquid into the center of a moving stream of a second liquid (of differing surface tension) and breaking the core stream into uniform droplets by the action of a piezoelectric transducer. Fluorescent spheres of 10 μ diam have been produced having a coefficient of variation in volume and fluorescence as low as 3.6%. This corresponds to a diameter variation of about 1.5%.

Uniform Polymer Microspheres: Monodispersity Criteria, Methods of Formation and Applications

“…A strategy commonly utilized to promote droplet break-up in single-channel systems is the application of external forces, such as piezoelectric [61,62], acoustic [62][63][64][65], gravitational and rotational [66], vibration [67,68], and/or pneumatic [69] forces. PLA -chelator Lung imaging with radiolabeled MS 9.00 ± 0.44 µm/4.9% [56] ZrO 2…”

“…The technique allows the production of MS uniform in volume and fluorescence or radioactive tracer ZrO 2 : 10 µm/NA Poly-St: 2-30 µm/1.5% [62] PLGA The apparatus utilized provides control of MS size and allows development of advanced controlled release delivery systems~5…”

Synthesis of plastic scintillation microspheres: Evaluation of scintillators

“…Among the different procedures described in the literature for the synthesis of polymeric microspheres [22][23][24], the most important are drop disruption using microwaves [25,26], polymerisation [27][28][29] and evaporation/extraction [30,31]. The advantage of evaporation/extraction is that it can be easily implemented in a laboratory and that there are no reactions during the synthesis.…”

Fluorescent Ion‐Sensing Microspheres for Multiplexed Chemical Analysis of Clinical and Biological Samples

“…A diagram of the particle casting setup is shown in Figure 1.3.2. Developed nearly 30 years ago for the preparation of UO 2 and PuO 2 microspheres [74,75], this technology has more recently been used to prepare particle standards for flow cytometry calibration protocols and microsphere-based diagnostic assays [45,76,77]. The operating principle of the particle caster is relatively simple.…”