Production of the radioactive antitumoral cisplatin

Leal, Alexandre Soares; Júnior, Álvaro D. Carvalho; Abrantes, Fabiana Moreira; Menezes, Maria Ângela de B. C.; Ferraz, Vany; Cruz, Tamara S.; Cardoso, Valbert Nascimento; Oliveira, Mônica Cristina

doi:10.1016/j.apradiso.2005.07.004

Cited by 8 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Chemical structure of the tetracycline-platinum(II) complex specific activity of [Tc-Pt(II)]* can be obtained using higher times of irradiation. However, in this case, the sample must be irradiated inside a cadmium capsule to avoid the disruption of the molecule due to the SzilardChalmers effect that occurs during long irradiation times or higher neutron flux [23]. In this work, it was decided to irradiate without the cadmium capsules.…”

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

“…The time of decay of 1 h was the lowest required operational time, due to the transport of the [Tc-Pt(II)]*. For the samples, 2, 3 and 4, the time of irradiation of 3 h was used to obtain a higher specific activity of the Pt isotopes but without the risk of disrupting the molecule, that can occurs of higher time of irradiation are used [23]. The decay time of 3 h for sample 3, was used in order to get more operational flexibility between the end irradiation and the inoculation of the cells.…”

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

“…These times were chosen considering the following aspects: For the sample 1, the time of irradiation of 2 h was the minimum necessary to obtain some activity of Pt radioisotopes according our previous studies [9,23]. The time of decay of 1 h was the lowest required operational time, due to the transport of the [Tc-Pt(II)]*.…”

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

“…The samples of the [Tc-Pt(II)]* with 1.0-2.0 mg each were obtained in a similar way of the CDDP* using the TRIGA IPR-R1 research reactor of the CDTN, with thermal neutron flux of 6.4 9 10 11 cm -2 s -1 [23]. The gamma radiation counting system used was CANBERRA hyper pure germanium detector, (HPGe), nominal efficiency of 50 % and a full-width at half maximum resolution, (FWHM) of 1.75 at 1332 keV.…”

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

“…[23,25,26]. The final specific activity for [Tc-Pt(II)]* was approximately 60.0 Bq mg -1 after 24 h of decay.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Leal¹,

Marzano

Pereira-Maia

et al. 2016

J Radioanal Nucl Chem

View full text Add to dashboard Cite

The proposal of this work was to investigate the effect of the radioactive complex of platinum(II) with tetracycline, [PtCl 2 (C 22 H 24 N 2 O 8 )]*, or [Tc-Pt(II)]*, on K562 cells-blood human cells of leukemia-and verify if the internal radio-chemotherapy would be able to produce additional effects compared with the non-labelled complex, [PtCl 2 (C 22 H 24 N 2 O 8 )], or [Tc-Pt(II)]. The concentration required to inhibit 50 % of cellular growth, (IC 50 ), was 2.5 ± 0.2 lM for [Tc-Pt(II)]* and 14.5 ± 0.9 lM for the non-labelled molecule [Tc-Pt(II)]. This result suggest that the [Tc-Pt(II)]* could be a potent radiosensitizer evoking a supra additive effect. Treatment using the internal radiochemotherapy may be a useful alternative to reduce the drug concentration required for effective inhibition of the tumor growth.

show abstract

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

“…[23,25,26]. The final specific activity for [Tc-Pt(II)]* was approximately 60.0 Bq mg -1 after 24 h of decay.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Leal¹,

Marzano

Pereira-Maia

et al. 2016

J Radioanal Nucl Chem

View full text Add to dashboard Cite

show abstract

Evaluation of the synergetic radio-chemotherapy effects of the radio labelled cisplatin for the treatment of glioma

Soares

Mattos

Pujatti

et al. 2011

J Radioanal Nucl Chem

View full text Add to dashboard Cite

Platinum(II) complexes with thiourea derivatives containing oxygen, sulfur or selenium in a heterocyclic ring: computational studies and cytotoxic properties

Fuks

Anuszewska

Kruszewska

et al. 2010

Transition Met Chem

View full text Add to dashboard Cite

Platinum(II) complexes with 1-(2-oxolanylmethyl)-2-thiourea, 1-(2-thiolanylmethyl)-2-thiourea and 1-(2-selenolanylmethyl)-2-thiourea were synthesized in order to compare their cytotoxic activities with those of the free thioureas. Their equilibrium geometries and bonding energies in the gas phase and in solution were calculated using density functional theory at the MPW1PW/LanL2DZ level. The IR spectra of the complexes and their free ligands were compared. Stability of the complexes in 0.9% saline aqueous solution was tested by means of HPLC. The cytotoxic activities of the species against five human cell lines were evaluated, as well as the antimicrobial activities against twelve bacterial strains.

show abstract

Production of the radioactive antitumoral cisplatin

Cited by 8 publications

References 9 publications

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Evaluation of the synergetic radio-chemotherapy effects of the radio labelled cisplatin for the treatment of glioma

Platinum(II) complexes with thiourea derivatives containing oxygen, sulfur or selenium in a heterocyclic ring: computational studies and cytotoxic properties

Contact Info

Product

Resources

About