Production of the bioactive pigment elsinochrome A by a cultured mycobiont strain of the lichen Graphis elongata

Fazio, Alejandra Teresa; Adler, M. T.; Parnmen, Sittiporn; Lücking, Robert; Maier, Marta S.

doi:10.1007/s11557-017-1374-1

Cited by 7 publications

(4 citation statements)

References 68 publications

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“…Other microorganisms can also produce Elsinochrome, for example, Elsinochrome C is produced by Parastagonospora nodorum ( Chooi et al, 2017 ). The mycobiont fungal strain of the lichen Graphis elongata biosynthesizes Elsinochrome A ( Fazio et al, 2018 ). Hypomyces sp., a parasitic mushroom fungus, produces hypomycin A (27) and B (28) , with structures closely related to the elsinochromes ( Liu et al, 2001 ; Zhang et al, 2001 ).…”

Section: Microbial Perylenequinones Structural Diversity and Bioactivitymentioning

confidence: 99%

Advances and perspectives on perylenequinone biosynthesis

et al. 2022

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Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in excess can damage cellular macromolecules and trigger apoptosis. Based on this property, PQs have been widely used as photosensitizers and applied in pharmaceuticals, which has stimulated research into the discovery of new PQs and the elucidation of their biosynthetic pathways. The PQs-associated literature covering from April 1967 to September 2022 is reviewed in three sections: (1) the sources, structural diversity, and biological activities of microbial PQs; (2) elucidation of PQ biosynthetic pathways, associated genes, and mechanisms of regulation; and (3) advances in pathway engineering and future potential strategies to modify cellular metabolism and improve PQ production.

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Section: Microbial Perylenequinones Structural Diversity and Bioactivitymentioning

confidence: 99%

Advances and perspectives on perylenequinone biosynthesis

et al. 2022

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“…The phylogenetic analyses were based on nrLSU, mtSSU and RPB2. We prepared a dataset of reference sequences (Table 1) generated in previous studies of Graphidaceae and other fungi (Kalb et al 2004;Staiger et al 2006;Mangold et al 2008;Rivas Plata et al 2011Cáceres et al 2012;Nelsen et al 2012;McDonald et al 2013;Lumbsch et al 2014b;Fazio et al 2018;Vu et al 2019). Species of Acanthothecis, Diploschistes and Fissurina, representing three different Graphidaceae clades outside tribe Graphideae (Lumbsch et al 2014a), were used for the outgroup.…”

Section: Molecular Phylogeneticsmentioning

confidence: 99%

Contribution to a modern treatment of Graphidaceae biodiversity in South Africa: genera of tribe Graphideae with hyaline ascospores

Medeiros

Lutzoni

2022

The Lichenologist

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Additions and corrections are provided for the South African species of Graphidaceae tribe Graphideae with hyaline ascospores. Allographa oldayana I. Medeiros sp. nov. is described as new to science based on morphological, chemical and molecular data. The new species is characterized by lirellae with striate labia and a complete thalline margin, a completely carbonized excipulum, large, muriform ascospores, and the presence of hirtifructic acid. Allographa consanguinea (Müll. Arg.) Lücking, A. leptospora (Vain.) Lücking & Kalb, Diorygma aff. minisporum Kalb et al., Graphis crebra Vain., Gr. dupaxana Vain., Gr. furcata Fée, Gr. handelii Zahlbr., Gr. longula Kremp., Gr. pinicola Zahlbr., Gr. proserpens Vain, Gr. subhiascens (Müll. Arg.) Lücking and Platythecium sp. are reported as new records for South Africa. Allographa striatula (Ach.) Lücking & Kalb, Graphis analoga Nyl. and Gr. scripta (L.) Ach. are shown to be misapplied names that should be removed from the South African checklist. The new combination Mangoldia bylii (Vain.) I. Medeiros comb. nov. (bas. Graphis bylii Vain) is made; this represents an earlier name for M. atronitens (A. W. Archer) Lücking et al. Taxonomic notes are provided for Graphis bylii var. lividula Vain. and Gr. denudans Vain., species that are known only from their South African holotypes. Phylogenetic analyses that include new DNA sequence data from the nrLSU, mtSSU and RPB2 loci confirm the generic placements of several species for which molecular data were lacking: Allographa consanguinea, Glyphis atrofusca (Müll. Arg.) Lücking, Graphis crebra and Gr. subhiascens.

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“…These Bacillus_I isolates were prioritized by the enrichment method based on the presence of the BGC family "nrps2550". The BGC family "nrps2550" shares homology with the BGC known to produce Elsinochrome A. Elsinochrome A is a perylenequinone, a family of molecules which are known to exhibit fungicidal activity by production of reactive oxygen species (29,30) .…”

Section: To Identify Biosynthetic Pathways Associated With Control Ofmentioning

confidence: 99%

Genomics-accelerated discovery of diverse fungicidal bacteria

Biggs

Craig

Gachango

et al. 2020

Preprint

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Sorghum Anthracnose and Black Sigatoka of bananas are problematic fungal diseases worldwide, with a particularly devastating impact on small-holder farmers in Sub-Saharan Africa. We screened a total of 1,227 bacterial isolates for antifungal activity against these pathogens using detached-leaf methods and identified 72 isolates with robust activity against one or both of these pathogens. These bacterial isolates represent a diverse set of five phyla, 14 genera and 22 species, including taxa for which this is the first observation of fungal disease suppression. We identified biosynthetic gene clusters associated with activity against each pathogen. Through a machine learning workflow we discovered additional active isolates, including an isolate from a genus that had not been included in previous screening or model training. Machine-learning improved the discovery rate of our screen by 3-fold. This work highlights the wealth of biocontrol mechanisms available in the microbial world for management of fungal pathogens, generates opportunities for future characterization of novel fungicidal mechanisms, and provides a set of genomic features and models for discovering additional bacterial isolates with activity against these two pathogens.

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Production of the bioactive pigment elsinochrome A by a cultured mycobiont strain of the lichen Graphis elongata

Cited by 7 publications

References 68 publications

Advances and perspectives on perylenequinone biosynthesis

Advances and perspectives on perylenequinone biosynthesis

Contribution to a modern treatment of Graphidaceae biodiversity in South Africa: genera of tribe Graphideae with hyaline ascospores

Genomics-accelerated discovery of diverse fungicidal bacteria

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