Production of positron-emitting 110mIn via the process

Rösch, Frank; Qaim, S. M.; Novgorodov, A.F.; Tsai, Ying-Ming

doi:10.1016/s0969-8043(96)00041-3

Cited by 23 publications

(25 citation statements)

References 9 publications

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“…11 In particular, careful selection of the irradiation parameters can minimize the production of unwanted radionuclidic impurities. For example, 89 Zr is a promising PET radionuclide for labeling monoclonal antibodies (mAbs) for use in immuno-PET imaging, and its production via the 89 Y( p , n ) 89 Zr transmutation reaction using 100% naturally abundant 89 Y thin metal foils has been studied in detail by several groups. 39 -44 However, many previous attempts to prepare 89 Zr in high radionuclide, radiochemical, and chemical purity have suffered from diffi culties arising from the complex separation chemistry and contamination from the longer-lived nuclides 88 Zr ( t 1/2 = 83.4 days) and 88 Y ( t 1/2 = 106.626 days).…”

Section: Cyclotron-produced Pet Radionuclidesmentioning

confidence: 99%

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Unconventional Nuclides for Radiopharmaceuticals

2010

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Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy of disease has been the driving force behind burgeoning research interests in the design of novel radiopharmaceuticals. Until recently, the majority of clinical and basic science research has focused on the development of 11C-, 13N-, 15O-, and 18F-radiopharmaceuticals for use with positron emission tomography (PET) and 99mTc-labeled agents for use with single-photon emission computed tomography (SPECT). With the increased availability of small, low-energy cyclotrons and improvements in both cyclotron targetry and purification chemistries, the use of “nonstandard” radionuclides is becoming more prevalent. This brief review describes the physical characteristics of 60 radionuclides, including β+, β−, γ-ray, and α-particle emitters, which have the potential for use in the design and synthesis of the next generation of diagnostic and/or radiotherapeutic drugs. As the decay processes of many of the radionuclides described herein involve emission of high-energy γ-rays, relevant shielding and radiation safety issues are also considered. In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64Cu, 68Ga, 86Y, 89Zr, and 124I are discussed.

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Section: Cyclotron-produced Pet Radionuclidesmentioning

confidence: 99%

“…1 The following discussion provides an up-to-date extension of the aforementioned article and covers a more extensive range of radionuclides. In addition, the potential impact of unconventional PET radionuclides on radiation safety is considered by way of a case study on the increasingly prevalent nuclides 64 Cu, 68 Ga, 86 Y, 89 Zr, and 124 I.…”

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confidence: 99%

Unconventional Nuclides for Radiopharmaceuticals

2010

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“…110m In can be mainly produced by two methods, direct reaction or indirectly by generator. The generator of 110 In was produced via 110 Cd( 3 He,xn) 110 Sn→ 110 In by Szelecsényi et al (1991) and 110m In generator via the 110 Cd( 3 He,3n) 110 Sn→ 110m In process was produced by Rösch et al (1997). Because of high incident proton energy in generator based production and low production yield, usage of them does not seem to be more interesting than a direct reaction to produce 110m In.…”

Section: Introductionmentioning

confidence: 99%

Nuclear model calculation and targetry recipe for production of 110mIn

Kakavand

Mirzaii²,

Eslami

et al. 2015

Applied Radiation and Isotopes

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“…44 Scmarkierten Radiopharmaka ± auch als längerlebige Alternative im Vergleich zu 68 Ga ± neue Aufmerksamkeit zukommt. 44 Ti kann durch die 45 [81,82]. Direkte Produktionen von 110m In nach 110 Cd(p,n)-, 107 Ag(a,n)oder 109 Ag( 3 He,2n)-Prozessen populieren hauptsächlich das Isomer 110g In (T Ý = 4,9 h).…”

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“…Direkte Produktionen von 110m In nach 110 Cd(p,n)-, 107 Ag(a,n)oder 109 Ag( 3 He,2n)-Prozessen populieren hauptsächlich das Isomer 110g In (T Ý = 4,9 h). Isotop-reines 110m In ist nur über den sekundären Weg des Radionuklid-Generatorsystems 110 Sn/ 110m In zugänglich [81]. 110 Eine Reihe von 72 Se/ 72 As-Generatorkonzeptionen ist publiziert, wobei generell ein makroskopischer Selen-Trägerzusatz verwendet wurde ( [83 ± 86] u.…”

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Radionuklid-Generatorsysteme für die PET

Rösch¹

2004

Der Nuklearmediziner

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EinleitungAls Radionuklid-Generator wird ein System definiert, das es erlaubt, durch einen effektiven radichemischen Prozess von einem (in der Regel relativ langlebigem) Mutternuklid das generierte Tochternuklid in einer hohen radionuklidischen und radiochemischen Reinheit zu separieren. Da im Allgemeinen die radioaktive Umwandlung eines Nuklids in der Bildung eines längerlebi-gen bzw. letztlich stabilen Folgekerns resultiert, bilden Radionuklid-Generatorsysteme, bei denen das Tochternuklid eine kür- ZusammenfassungIn Bezug auf Anwendungen in der Positronen-Emissions-Tomographie (PET) kombinieren die Radionuklid-Generatorsysteme das hohe Potenzial der PET und zunehmend der PET/CT erfolgreich mit (i) den logistischen Vorteilen der bequemen Verfügbar-keit der Generatortochter ohne Bindung an In-house-ZyklotronProduktionen, (ii) der entweder gar nicht erforderlichen Synthesechemie (bei Perfusions-Generatorsystemen) bzw. im Fall von Markierungsreaktionen der in der Regel ¹kitª-artigen Synthese und (iii) nicht zuletzt ökonomischen Aspekten. Im Kontext der molekularen Bildgebung bzw. der Anwendung radiomarkierter Verbindungen für verschiedenste medizinisch relevante Fragestellung sind neueste Nutzungen von Radionuklid-Generatorsystemen vor allem für die Tumordiagnostik interessant, da sie die Szintigraphie membranständiger Tumorrezeptoren und die Bildgebung von Antikörper-Antigen-Wechselwirkungen erlauben. Speziell für 68 Ga-DOTA-konjugierte Targetingvektoren lassen sich vielfältige Anwendungen erwarten. AbstractApplications of radionuclide generator systems for Positron Emission Tomography increasingly combine the significant potential of PET with several advantages. Among those, there are (i) the logistic advantages of the readily available generator daughter nuclide avoiding in house cyclotron production capacities and (ii) the non-necessary syntheses in the case of perfusiontype generators, or, if labelling procedures are required, the rather straight forward kit-type syntheses. Finally, (iii) economic factors are relevant. Recent developments of radionuclide generators are in particular relevant for molecular imaging and the application of radiolabeled tracers for a variety of diagnostic studies such as the scintigraphy of tumour receptors, overexpressed at the tumour cell membrane, and for the detection of antibody-antigen interactions. In particular 68 Ga-DOTA conjugated targeting vectors provide a most interesting potential. Key wordsRadionuclide generators´PET´6 8 Ga´DOTA´tumor targeting vectors PET in der Onkologie ± aktueller Stand 226 Heruntergeladen von: University of Florida. Urheberrechtlich geschützt.

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Production of positron-emitting 110mIn via the process

Cited by 23 publications

References 9 publications

Unconventional Nuclides for Radiopharmaceuticals

Unconventional Nuclides for Radiopharmaceuticals

Nuclear model calculation and targetry recipe for production of 110mIn

Radionuklid-Generatorsysteme für die PET

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