Nuclear model calculation and targetry recipe for production of 110mIn

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

“…The most promising methods for direct production of 110m In include 110 Cd­(p,n), 107 Ag­(α,n), and 109 Ag­( 3 He,2n); however, coproduction of 110g In ( t 1/2 = 4.9 h) tends to dilute isotopic purity and remains problematic . For example, following yield-optimizing calculations, Kakavand et al irradiated nat Cd with 15 MeV protons (100 μA, 1 h) and produced 44.3 ± 8.8 GBq/C (gigabecquerel per Coulomb) with 1.25 ± 0.25 GBq/C 110g In impurity. , Indirect production using 110 Sn ( t 1/2 = 4.11 h, EC 100%) as a parent radionuclide can yield 110g In-free 110m In following electron capture and is achieved via 113 In­(p,4n), 113 In­(d,5n), 110 Cd­( 3 He,3n), 108 Cd­(α,2n), or 110 Cd­(α,4n). ,− To make future use viable, production of 111/113 In must be mitigated through the use of enriched targets and beam energy optimization . A clinical proof-of-concept study with 110m In-DTPA- d -Phe-octreotide was conducted in 2002 to demonstrate the superiority of 110m In PET compared to 111 In SPECT.…”

“…401 For example, following yield-optimizing calculations, Kakavand et al irradiated nat Cd with 15 MeV protons (100 μA, 1 h) and produced 44.3 ± 8.8 GBq/C (gigabecquerel per Coulomb) with 1.25 ± 0.25 GBq/C 110g In impurity. 402,403 Indirect production using 110 Sn (t 1/2 = 4.11 h, EC 100%) as a parent radionuclide can yield 110g In-free 110m In following electron capture and is achieved via 113 In(p,4n), 113 In(d,5n), 110 Cd-( 3 He,3n), 108 Cd(α,2n), or 110 Cd(α,4n). 401,404−406 To make future use viable, production of 111/113 In must be mitigated through the use of enriched targets and beam energy optimization.…”

Radionuclide candidates for β+γ coincidence PET: An overview

“…The direct production of 110m In (J π = 2 + ) always leads to the co-formation of the radioactive impurity 110g In (J π = 7 + ) but the higher isomeric ratio can be achieved with lower projectile energies. The recommended reaction, 110 Cd(p,n) (Otozai et al, 1966;Abramovich et al, 1975;Skakun et al, 1975;Kormali et al, 1976;Marten et al, 1985;Nortier et al, 1990;Tárkányi et al, 11/38 2006Tárkányi et al, 11/38 , 2015Al-Saleh, 2008;Khandaker et al, 2008;Büyükuslu et al, 2010), at 15 MeV energy (available in the commonly used machines) and with electroplated nat Cd target (Kakavand et al, 2015b) yields 160 MBq/uAh of 110m In with reported 3% of 110g In and 6% of 111g In radioactive impurities (Mukhammedov et al, 1984;Kakavand et al, 2015b).…”