“…The most promising methods for direct production of 110m In include 110 Cd(p,n), 107 Ag(α,n), and 109 Ag( 3 He,2n); however, coproduction of 110g In ( t 1/2 = 4.9 h) tends to dilute isotopic purity and remains problematic . For example, following yield-optimizing calculations, Kakavand et al irradiated nat Cd with 15 MeV protons (100 μA, 1 h) and produced 44.3 ± 8.8 GBq/C (gigabecquerel per Coulomb) with 1.25 ± 0.25 GBq/C 110g In impurity. , Indirect production using 110 Sn ( t 1/2 = 4.11 h, EC 100%) as a parent radionuclide can yield 110g In-free 110m In following electron capture and is achieved via 113 In(p,4n), 113 In(d,5n), 110 Cd( 3 He,3n), 108 Cd(α,2n), or 110 Cd(α,4n). ,− To make future use viable, production of 111/113 In must be mitigated through the use of enriched targets and beam energy optimization . A clinical proof-of-concept study with 110m In-DTPA- d -Phe-octreotide was conducted in 2002 to demonstrate the superiority of 110m In PET compared to 111 In SPECT.…”