Production of PLGA micro- and nanocomposites by supercritical fluid extraction of emulsions: II. Encapsulation of Ketoprofen

Kluge, Johannes; Fusaro, Francesco; Mazzotti, Marco; Muhrer, Gerhard

doi:10.1016/j.supflu.2009.05.002

Cited by 38 publications

(27 citation statements)

References 22 publications

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“…For example, it has been demonstrated for the case of RS-KET at ambient conditions that an equivalent level, i.e. the equilibrium solubility of KET in PLGA, is ultimately attained by following either procedure (Kluge et al, 2009b). On the other hand, if equilibrium is not reached, impregnation and de-supersaturation experiments still provide a lower and an upper bound, respectively, for the solubility of KET in PLGA.…”

Section: Resultsmentioning

confidence: 99%

“…A previous study carried out at ambient temperatures has shown that the uptake of KET by impregnation takes place immediately after mixing. Although the experiment has been continued during the following week, a further increase of the impregnated drug content was not observed (Kluge et al, 2009b). Based on this experience, an impregnation time of 1 day has been used in the present study, and we presume that equilibrium between KET and PLGA is reliably established within this time frame.…”

Section: Equilibration-impregnation Experimentsmentioning

confidence: 92%

“…However, the equilibration process may be facilitated by using polymeric nanoparticles, where diffusion distances are short, and consequently, equilibration is fast. In this context, a previous study has successfully demonstrated that solvent-free PLGA nanoparticles as obtained by SFEE processing may be used to investigate the equilibration of PLGA with crystalline Ketoprofen (KET), a chiral molecule belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs) (Kluge et al, 2009b).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solubility of Ketoprofen in colloidal PLGA

Kluge¹,

Mazzotti²,

Muhrer³

2010

International Journal of Pharmaceutics

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Section: Resultsmentioning

confidence: 99%

Section: Equilibration-impregnation Experimentsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solubility of Ketoprofen in colloidal PLGA

Kluge¹,

Mazzotti²,

Muhrer³

2010

International Journal of Pharmaceutics

Self Cite

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“…High-speed stirring mixers [46], [47], [51], high-pressure homogenization [45], [53], [54], and ultrasonication [55][56][57][58] have been used to form fine emulsions for use in the SFEE process. Microfluidization is an additional alternative for preparing submicron emulsions.…”

Section: Emulsion Preparationmentioning

confidence: 99%

“…The compounds lysozyme (hydrophilic) and ketoprofen (hydrophobic) have been incorporated in poly-lactic-co-glycolic acid (PLGA) using the SFEE process [55], [62]. These authors investigated the phase equilibrium established between ketoprofen and PLGA to further underline the potential of SFEE to serve as a viable manufacturing technique and to highlight a novel application opportunity for this process [56].…”

Section: Applicationsmentioning

confidence: 99%

Trends in Particle Formation of Bioactive Compounds Using Supercritical Fluids and Nanoemulsions

Gomes¹,

Santos²,

Meireles³

2012

fph

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This review discusses the recent developments in the application of supercritical fluid technologies for the production of composites or encapsulates of bioactive compounds. Various supercritical particle formation technologies are briefly described, including processes in which the supercritical fluid acts as a solute, solvent, and antisolvent. The main features and mechanisms of antisolvent techniques that contribute to the understanding of the fundamentals of the Supercritical Fluid Extraction of Emulsions (SFEE) process are described. The published literature on SFEE, including the results and perspectives of its application in various industrial fields, are discussed. This article is the first comprehensive review specifically focused on the formation of particles using the SFEE technique.

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Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

224

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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Production of PLGA micro- and nanocomposites by supercritical fluid extraction of emulsions: II. Encapsulation of Ketoprofen

Cited by 38 publications

References 22 publications

Solubility of Ketoprofen in colloidal PLGA

Solubility of Ketoprofen in colloidal PLGA

Trends in Particle Formation of Bioactive Compounds Using Supercritical Fluids and Nanoemulsions

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

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