“…The well-known approach employing hydrogen peroxide (H 2 O 2 , a strong oxidant) has been increasingly applied to degrade various polysaccharides, due to its strong oxidation ability and environmental-friendly characteristics. − Several highly reactive free radicals, such as hydroxyl radical ( • OH), singlet oxygen ( 1 O 2 ), and superoxide radical (O 2 •– ), are capable of degrading polysaccharides and can be activated by various treatments, including metal ions, ascorbic acid, ultrasound, microwave, solution plasma, and ultraviolet (UV) radiation . Furthermore, many studies have reported that free radical-induced structural changes in degraded polysaccharides can efficiently improve their bioactivities, such as the antioxidant activities of degraded Tremella fuciformis, Porphyra yezoensis, Codium cylindricum, and Auricularia auricula polysaccharides; the anti-inflammatory activities of degraded pectin and Hylocereus undatus polysaccharides; ,, the antitumor activities of degraded pectin and glycosaminoglycan polysaccharides; , the probiotic activity of degraded pectin polysaccharide; and the hypoglycemic activity of degraded honeysuckle polysaccharide .…”