Production of medical radioisotopes with high specific activity in photonuclear reactions with γ-beams of high intensity and large brilliance

Habs, D.; Köster, U.

doi:10.1007/s00340-010-4278-1

Cited by 82 publications

(78 citation statements)

References 48 publications

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“…However, a significant drawback of this production route is the high price of enriched 46 Ca as a result of its extremely low abundance of only 0.004% in natural calcium. Alternative routes for the production of 47 Sc have been reported in the literature (23)(24)(25)(26). Among these, the most feasible appears to be the irradiation of 47 Ti targets with fast neutrons to induce the 47 Ti(n,p) 47 Sc nuclear reaction (25,27,28).…”

Section: Discussionmentioning

confidence: 99%

Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice

et al. 2014

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In recent years, 47 Sc has attracted attention because of its favorable decay characteristics (half-life, 3.35 d; average energy, 162 keV; Eγ, 159 keV) for therapeutic application and for SPECT imaging. The aim of the present study was to investigate the suitability of 47 Sc for radionuclide therapy in a preclinical setting. For this purpose a novel DOTA-folate conjugate (cm10) with an albumin-binding entity was used. Methods: 47 Sc was produced via the 46 Ca(n,γ) 47 Ca! b − 47 Sc nuclear reaction at the high-flux reactor at the Institut Laue-Langevin. Separation of the 47 Sc from the target material was performed by a semi-automated process using extraction chromatography and cation exchange chromatography. 47 Sc-labeled cm10 was tested on folate receptor-positive KB tumor cells in vitro. Biodistribution and SPECT imaging experiments were performed in KB tumor-bearing mice. Radionuclide therapy was conducted with two groups of mice, which received either 47 Sc-cm10 (10 MBq) or only saline. Tumor growth and survival time were compared between the two groups of mice. Results: Irradiation of 46 Ca resulted in approximately 1.8 GBq of 47 Ca, which subsequently decayed to 47 Sc. Separation of 47 Sc from 47 Ca was obtained with 80% yield in only 10 min. The 47 Sc was then available in a small volume (∼500 μL) of an ammonium acetate/HCl (pH 4.5) solution suitable for direct radiolabeling. 47 Sc-cm10 was prepared with a radiochemical yield of more than 96% at a specific activity of up to 13 MBq/nmol. In vitro 47 Sccm10 showed folate receptor-specific binding and uptake into KB tumor cells. In vivo SPECT/CT images allowed the visualization of accumulated radioactivity in KB tumors and in the kidneys. The therapy study showed a significantly delayed tumor growth in mice, which received 47 Sc-cm10 (10 MBq, 10 Gy) resulting in a more than 50% increase in survival time, compared with untreated control mice. Conclusion: With this study, we demonstrated the suitability of using 47 Sc for therapeutic purposes. On the basis of our recent results obtained with 44 Sc-folate, the present work confirms the applicability of 44 Sc/ 47 Sc as an excellent matched pair of nuclides for PET imaging and radionuclide therapy.

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Section: Discussionmentioning

confidence: 99%

Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice

et al. 2014

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“…226 Ra(γ.n) 225 Ra as a source for the promising 225 Ac generator for targeted alpha therapy [Hab11].…”

Section: Gamma Induced Nuclear Reactionsmentioning

confidence: 99%

Ion and Neutron Beams Discover New Facts from History

Macková

Kučera

Kameník

et al. 2017

Nuclear Physics News

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“…The new production schemes of medical isotopes [15] (e.g., 99 Mo -currently used in therapies, 195m Pt -nuclear imaging to determine efficiency of chemotherapy, 117m Sn -emitter of low energy Auger electrons for tumour therapy) via (γ,n) processes may also reach socio-economical relevance.…”

Section: Experiments Based On the Gamma Beammentioning

confidence: 99%

Extreme Light Infrastructure Nuclear Physics (ELI–NP): Present status and perspectives

Zamfir

2016

EPJ Web of Conferences

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Extreme Light Infrastructure -Nuclear Physics (ELI-NP), a new Research Center under construction, will use extreme electromagnetic fields for nuclear physics research and will be operational in 2018. The status of the Project implementation will be presented. At ELI-NP, a high power laser system together with a very brilliant gamma beam are the two main research tools. Their targeted operational parameters will be described. The related experimental set-ups will be presented, together with the main directions of the research envisioned.

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Production of medical radioisotopes with high specific activity in photonuclear reactions with γ-beams of high intensity and large brilliance

Abstract: We study the production of radioisotopes for nuclear medicine in (γ, xn + yp) photonuclear reactions or (γ, γ ′ ) photoexcitation reactions with high flux [(10 13 − 10 15 )γ/s], small diameter ∼ (100 µm) 2 and small band width (∆E/E ≈ 10 −3 − 10 −4 ) γ beams pro-

Cited by 82 publications

References 48 publications

Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice

Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice

Ion and Neutron Beams Discover New Facts from History

Extreme Light Infrastructure Nuclear Physics (ELI–NP): Present status and perspectives

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Production of medical radioisotopes with high specific activity in photonuclear reactions with γ-beams of high intensity and large brilliance

Abstract: We study the production of radioisotopes for nuclear medicine in (γ, xn + yp) photonuclear reactions or (γ, γ ′ ) photoexcitation reactions with high flux [(10 13 − 10 15 )γ/s], small diameter ∼ (100 µm) 2 and small band width (∆E/E ≈ 10 −3 − 10 −4 ) γ beams pro-

Cited by 82 publications

References 48 publications

Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice

Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice

Ion and Neutron Beams Discover New Facts from History

Extreme Light Infrastructure Nuclear Physics (ELI–NP): Present status and perspectives

Contact Info

Product

Resources

About

Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice

Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice