Production of isoquinoline alkaloids from the in vitro conserved Fumaria parviflora and their in vitro wound healing activity

Elsaid, Mostafa B.; Elnaggar, Dina M. Yousry; Owis, Asmaa I.; AbouZid, Sameh; El-Dahmy, S.

doi:10.1080/14786419.2021.1904401

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Alkaloids also play an enormous role in the process of wound healing. They can enhance macrophage chemotaxic and neutrophil mobilization towards the wounded area [ 87 ]. Alkaloids also have wound-healing activity, which may be attributed to their anti-inflammatory properties [ 88 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

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Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, SAN has also been shown to have pain-relieving (through inhibition of the MAPK signaling pathway) and wound-healing properties that could help treat hoof disease and improve animal welfare. [73][74][75]. SAN's potential role in protecting osteoblasts, preventing osteoarthritis, and regulating osteophytes is also closely linked to the prevention and prognosis of hoof disease [76][77][78].…”

Section: Discussionmentioning

confidence: 99%

Integrating Network Pharmacology and Molecular Docking to Analyse the Potential Mechanism of action of Macleaya cordata (Willd.) R. Br. in the Treatment of Bovine Hoof Disease

Dong

Liu

Zou

et al. 2021

Veterinary Sciences

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Based on network pharmacological analysis and molecular docking techniques, the main components of M. cordata for the treatment of bovine relevant active compounds in M. cordata were searched for through previous research bases and literature databases, and then screened to identify candidate compounds based on physicochemical properties, pharmacokinetic parameters, bioavailability, and drug-like criteria. Target genes associated with hoof disease were obtained from the GeneCards database. Compound−target, compound−target−pathway−disease visualization networks, and protein−protein interaction (PPI) networks were constructed by Cytoscape. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed in R language. Molecular docking analysis was done using AutoDockTools. The visual network analysis showed that four active compounds, sanguinarine, chelerythrine, allocryptopine and protopine, were associated with the 10 target genes/proteins (SRC, MAPK3, MTOR, ESR1, PIK3CA, BCL2L1, JAK2, GSK3B, MAPK1, and AR) obtained from the screen. The enrichment analysis indicated that the cAMP, PI3K-Akt, and ErbB signaling pathways may be key signaling pathways in network pharmacology. The molecular docking results showed that sanguinarine, chelerythrine, allocryptopine, and protopine bound well to MAPK3 and JAK2. A comprehensive bioinformatics-based network topology strategy and molecular docking study has elucidated the multi-component synergistic mechanism of action of M. cordata in the treatment of bovine hoof disease, offering the possibility of developing M. cordata as a new source of drugs for hoof disease treatment.

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“…The structural similarity between the isolated alkaloids made it possible to study the structure-activity relationship (SAR), including sanguinarine showing strong activity compared to other alkaloids. The imine ion and methylenedioxyphenol additionally enhance its activity [32].…”

Section: Capparis Spinosa Lmentioning

confidence: 99%

Charakterystyka wybranych roślin leczniczych pochodzących z Iraku

Noaema¹,

Sawicka

Kiełtyka-Dadasiewicz

et al. 2023

HERB

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W pracy scharakteryzowano najważniejsze rośliny szeroko stosowane w Iraku do celów leczniczych. Zastosowano metodę opisową na podstawie danych literaturowych. Badania wykazały, że wiele roślin leczniczych stosowanych w Iraku, a należących do różnych rodzin botanicznych wykorzystywano w medycynie tradycyjnej do leczenia chorób. W niniejszej pracy przedstawiono 10 najważniejszych roślin należących do 9 rodzin botanicznych, które były i są nadal wykorzystane i używane jako rośliny lecznicze. Większość rodzimych roślin wciąż wymaga szczegółowych badań, które mogą dostarczyć wielu interesujących danych. Znajomość tradycyjnej wiedzy i roślinleczniczych może odegrać kluczową rolę w eksploatacji i odkrywaniu naturalnych zasobów roślinnych w Iraku.

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Production of isoquinoline alkaloids from the in vitro conserved Fumaria parviflora and their in vitro wound healing activity

Cited by 6 publications

References 14 publications

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Integrating Network Pharmacology and Molecular Docking to Analyse the Potential Mechanism of action of Macleaya cordata (Willd.) R. Br. in the Treatment of Bovine Hoof Disease

Charakterystyka wybranych roślin leczniczych pochodzących z Iraku

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