Production of immunity and unresponsiveness in the mouse by feeding contact sensitizing agents and the role of suppressor cells in the Peyer's patches, mesenteric lymph nodes and other lymphoid tissues

In vitro studies of poison oak immunity. I. In vitro reaction of human lymphocytes to urushiol.

“…The number of false negatives in this test could indicate that suppressor cells may be a prominent feature in the human anti-urushiol cellular immune response. This was not noted in studies using hydrophilic moieties such as dinitrochlorobenzene in humans (21) but is consistent with findings in animals (22)(23)(24). Alternatively, the ability to present urushiol in an immunogenic fashion in vitro may vary between individuals.…”

Suppression of Delayed‐Type Contact Sensitivity in the Murine Oral Mucosa by Prior Intragastric Administration of Hapten

“…Here we show that a protocol involving gastric administration of a large amount of antigen known to be effective for inducing suppression of systemically induced skin CS reactions [3,[5][6][7], is also effective at inducing suppression of a bona fide mucosal CS response. The present study, however, demonstrates that the site of initial sensitization for a CS response is of critical importance in determining whether enteric suppression is effective or not.…”

“…A long recognized method for inducing systemic immunological tolerance is the enteric administration of antigens [1][2][3][4][5][6][7][8], socalled 'oral tolerance'. Depending on the dose and frequency of administration [9], oral antigens can induce systemic suppression via the generation of antigen-specific regulatory T cells producing immunosuppressive cytokines [10] or via direct anergy [11,12] or even deletion [13] of T cells producing pro-inflammatory cytokines.…”

Immunopathogenesis of cow’s milk allergy

“…22 These "non-professional" APC have been shown to express MHC Class II molecules, take up soluble proteins from the apical end, transport it basolaterally, and selectively activate CD8 suppressor cells. 23 The latter appears to be regulated by non classical class I molecules (CD1d) and other novel membrane molecules that interact with CD8. 24 It has been hypothesized that soluble antigens in the gut lumen are sampled and presented primarily by IECs, leading to suppression of the immune response, whereas M cells, leading to active immunity and generation of IgA, sample particulate antigens and intact bacteria, viruses, and parasites.…”