Production of extracellular inulinase in high-cell-density fed-batch cultures of Kluyveromyces marxianus

High-Cell-Density Cyclic Fed-Batch Fermentation of a Poly(3-Hydroxybutyrate)-Accumulating Thermophile, Chelatococcus sp. Strain MW10

“…Moreover, thermophilic fermentations are self-heated systems because the heat generated by the cell's metabolism during high-cell-density (HCD) growth (28,49) and also by stirring can be used for providing heat to the fermentation process itself. Thus, both heating and cooling costs are lowered (14,46). Additionally, unlike when mesophilic bacteria are used in fermentations, sterile conditions may not be essential during a process involving thermophilic bacteria (41,42).…”

Comparison of the Gene Expression Patterns of Alcohol Dehydrogenase Isozymes in the Thermotolerant YeastKluyveromyces marxianusand Their Physiological Functions

“…18,19) This yeast is also capable of growing on lactose as sole carbon source, which provides the possibility of utilizing cheese whey as a cheap source of nutrients for its cultivation. 20) K. marxianus has been investigated for the production of bioingredients, 18) cell proteins, 21,22) inulinase, 16,[23][24][25] and -galactosidase, [26][27][28] and even for use as a baker's yeast. 29) In spite of these potential applications of K. marxianus, there is a lack of information in the literature concerning its physiology.…”

Growth-rate-independent production of recombinant glucoamylase byFusarium venenatum JeRS 325

“…Theoretically, maximum productivity (q p ) of growth-ratecorrelated products will be obtained in high-dilution-rate chemostats or in turbidostats (de Hollander, 1993;Withers et al, 1998). However, industry prefers to use fed-batch cultures for the production of enzymes, even for recombinant proteins produced in a growth rate associated manner (Gu et al, 1991;Hensing et al, 1994). Production in fed-batch systems might be improved if the enzyme were produced in a manner independent of the growth rate, as shown in Figure 3.…”