Production of Endohedral Fullerenes by Ion Implantation

Abstract

A the start of this project however, methods for production of transition metal and p-clectron metaI endohedral lllerenes were completely unknown, and only one method for production of endohedral radiolllerencs was known. We thedore investigated three different methods for the production of therapeutically useful endohedral metallohllerenes: 1) implantation of ions using the high intensity ion beam at the Oak Ridge National Laboratory (ORNL) Surface Modification and C -* 'on Research Center (SMAC) and fullereaes as the targe 2) Implantation of ions using the recoil energy following alpha decay; and 3) implantation of ions using the recoil energy Mowing neutron capture, using O W ' S High Flux Isotope Reactor (HFIR) as a thermal neutron source. While we were unable to obtain evidence of successful implantation using the ion beam at SMAC, recoil following alpha decay and neutron capture were both found to be economically viable methods for the production of theqmtically usefid radiofidlerenes. In this report, the procdms for Preparing fullerenes containing the isatopes '"Pb, "' Bit "%i, and lnLu are described. None of these endohedd fullerenes had ever previously been pmpamd, and all of these radioisotope8 are actively under investigation for RIT. Additionally, the chemistry for derivatizing the radiofullerens for water-solubility and a method for removing exohedral radionuclides are reported. The methods and chemistry developed during this CRADA the crucial first steps for the development of Ml-es as a method superior to existing technologies for in vivo transport of radionuclides. ii. n f7 acid containing cold bismuth atoms. "Calculated" is how much "%i was actually inside of the lllerene at the times the washings were performed, back calculated from the 33 nCi tbat did not wash out during the last wash. List of Fmres

Perspectives of Fullerene Derivatives in PDT and Radiotherapy of Cancers

“…212 Pb@C 60 -malic acid [110] was stable under the beta decay of 212 Pb to 212 Bi and caused a weakening of 212 Pb myelotoxicity.…”