Perspectives of Fullerene Derivatives in PDT and Radiotherapy of Cancers

Орлова, М. А.

doi:10.9734/bjmmr/2013/3453

Cited by 27 publications

(10 citation statements)

References 108 publications

(118 reference statements)

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“…Comparing phototoxicity toward HaCaT of ( -CyD) 2 /C 60 (c-cyclodextrin bicapped C 60 ) and fullerenol, Zhao et al concluded that fullerenol was less phototoxic [68]. The aggregation of fullerenol in aqueous solution results in a loss of its intrinsic photochemical reactivity with respect to the production of superoxide and singlet oxygen [69,70]. The free radical (type I) mechanisms are considered to be involved in fullerenol phototoxicity.…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Djordjević

Srdjenović

Seke

et al. 2015

Journal of Nanomaterials

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This review describes the chemical synthesis of polar polyhydroxylated fullerene C60derivatives, fullerenols C60(OH)n,2≤n≤44, C60HzOx(OH)y, and polyanion fullerenols C60(OH)15(ONa)9, ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.

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Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Djordjević

Srdjenović

Seke

et al. 2015

Journal of Nanomaterials

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“…Fullerenes are very efficacious generators of singlet oxygen with a quantum yield of 1 O 2 close to one. They absorb light efficiently in the ultraviolet and moderately in the visible regions of the spectrum [14], which paves the way for their application in photodynamic therapy [15].…”

Section: Introductionmentioning

confidence: 99%

Biological Effects of C60 Fullerene Revealed with Bacterial Biosensor—Toxic or Rather Antioxidant?

et al. 2019

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Nanoparticles have been attracting growing interest for both their antioxidant and toxic effects. Their exact action on cells strongly depends on many factors, including experimental conditions, preparation, and solvents used, which have contributed to the confusion regarding their safety and possible health benefits. In order to clarify the biological effects of the most abundant fullerene C60, its impact on the Escherichia coli model has been studied. The main question was if C60 would have any antioxidant influence on the cell and, if yes, whether and to which extent it would be concentration-dependent. An oxidative stress induced by adding hydrogen peroxide was measured with an E. coli MG1655 pKatG-lux strain sensor, with its time evolution being recorded in the presence of fullerene C60 suspensions of different concentrations. Optimal conditions for the fullerene C60 solubilization in TWEEN 80 2% aqueous solution, together with resulting aggregate sizes, were determined. Results obtained for the bacterial model can be extrapolated on eukaryote mitochondria. The ability of C60 to penetrate through biological membranes, conduct protons, and interact with free radicals is likely responsible for its protective effect detected for E. coli. Thus, fullerene can be considered as a mitochondria-targeted antioxidant, worth further researching as a prospective component of novel medications.

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“…The enhanced efficiency of Dox included in nanoplatforms together with such photosenitizers as chlorin 6 [11,13,14], phthalocyanines [12,15,21], indocyanine green [22], merocyanine [9], methylene blue [10], and perfluorocarbon [16] was recently reported. The carbon nanostructure C 60 fullerene [23] (here abbreviated consistently C 60 ) has attracted attention as a photosensitizer [1,24,25,26,27] due to its unique physicochemical behavior, high quantum yield of ROS production [28], photostability, low photobleaching [25] as well as predominant mitochondrial localization [29,30,31,32]. Pristine C 60 stable colloid solution with a negligible toxicity against normal cells [33,34] was explored for PDT [26,28,31,35,36,37,38].…”

Section: Introductionmentioning

confidence: 99%

“…The carbon nanostructure C 60 fullerene [23] (here abbreviated consistently C 60 ) has attracted attention as a photosensitizer [1,24,25,26,27] due to its unique physicochemical behavior, high quantum yield of ROS production [28], photostability, low photobleaching [25] as well as predominant mitochondrial localization [29,30,31,32]. Pristine C 60 stable colloid solution with a negligible toxicity against normal cells [33,34] was explored for PDT [26,28,31,35,36,37,38]. A pronounced pro-apoptotic effect was detected in leukemic cells treated with pristine ≤20 µM C 60 and irradiated with UV-Vis light in the range of 320 – 600 nm [26,35,36,37,39,40].…”

Section: Introductionmentioning

confidence: 99%

Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex

et al. 2019

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A nanosized drug complex was explored to improve the efficiency of cancer chemotherapy, complementing it with nanodelivery and photodynamic therapy. For this, nanomolar amounts of a non-covalent nanocomplex of Doxorubicin (Dox) with carbon nanoparticle C60 fullerene (C60) were applied in 1:1 and 2:1 molar ratio, exploiting C60 both as a drug-carrier and as a photosensitizer. The fluorescence microscopy analysis of human leukemic CCRF-CEM cells, in vitro cancer model, treated with nanocomplexes showed Dox’s nuclear and C60’s extranuclear localization. It gave an opportunity to realize a double hit strategy against cancer cells based on Dox’s antiproliferative activity and C60’s photoinduced pro-oxidant activity. When cells were treated with 2:1 C60-Dox and irradiated at 405 nm the high cytotoxicity of photo-irradiated C60-Dox enabled a nanomolar concentration of Dox and C60 to efficiently kill cancer cells in vitro. The high pro-oxidant and pro-apoptotic efficiency decreased IC50 16, 9 and 7 × 103-fold, if compared with the action of Dox, non-irradiated nanocomplex, and C60’s photodynamic effect, correspondingly. Hereafter, a strong synergy of therapy arising from the combination of C60-mediated Dox delivery and C60 photoexcitation was revealed. Our data indicate that a combination of chemo- and photodynamic therapies with C60-Dox nanoformulation provides a promising synergetic approach for cancer treatment.

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Perspectives of Fullerene Derivatives in PDT and Radiotherapy of Cancers

Cited by 27 publications

References 108 publications

Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Biological Effects of C60 Fullerene Revealed with Bacterial Biosensor—Toxic or Rather Antioxidant?

Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex

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