PRODUCTION OF EMBRYONAL Α-Globulin BY TRANSPLANTABLE MOUSE HEPATOMAS

Excretion of Alpha-foetoprotein in the Urine of Pregnant Rats and Hepatoma-bearing animals

“…Sera from hepatoma-bearing rats and mice contain both foetoproteins (Abelev et al, 1963;Stanislawski-Birencwajg et al, 1967). In the present experiments, alpha-M-foetoprotein was found in the serum of a rat which was fed the carcinogenic diet for 6-l months, at a time when no abdominal masses were palpable.…”

Antinuclear Antibodies as Potential Markers of Lung Cancer

“…The humoral response in cancer has not received a great deal of attention recently because the quest for tumor-specific antigens has been largely long and fruitless (1)(2)(3). However, Tcell antigens have long been recognized to exist on tumor cells (4)(5)(6), and a cellular immune response without a concomitant humoral response would be unusual.…”

Human Alpha Fetoprotein in Body Fluids

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SINcE Pedersen (1944) described bovine fetuin, a fetal serum protein absent in adult cattle serum, similar proteins have been observed in various mammals including man (Abelev et al, 1963;Gitlin and Boesman 1967;Hull et al, 1969; Tatarinov, 1964). The importance of alpha fetoprotein (AFP) in the diagnosis of hepatocellular carcinoma was first demonstrated in mice (Abelev et al, 1963) and then in man (Tatarinov, 1964).

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“…The importance of alpha fetoprotein (AFP) in the diagnosis of hepatocellular carcinoma was first demonstrated in mice (Abelev et al, 1963) and then in man (Tatarinov, 1964). The relatively high incidence of primary liver cell carcinoma in the tropics including Nigeria (Berman, 1951;Higginson, 1956;Edington and Maclean, 1965; British Medical Journal, 1970) provides enough material for the study of this protein.…”