Production of Cysts Following Intramuscular Injection of Vegetable Oils

Active immunization against poliomyelitis

“…The reactions to such oils have been described as foreign body granulomata, benign oil tumors, oleomas or oil cysts, which sometimes result in slow-healing abscesses. 42,43 It should be noted that the surest way apparently to determine carcinogenicity of an oil is to inject it into a large number of mice, rats and rabbits intrammscularly, once a month for at least three months, and Poliomyelitis Symposium 94 5 946 BULLETIN observe the animals for the rest of their natcral lives. In extensive experiments by this procedure, Hueper44 has demonstrated sarcoma formation with oils that were entirely non-carcinogenic when applied to the skin.…”